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Your search keyword '"Transcription Factor AP-1"' showing total 2 results
Start Over Descriptor "Transcription Factor AP-1" Language german
2 results on '"Transcription Factor AP-1"'

1. [Molecular biology studies of a multicenter phase III study (SIC Study)]

Author

T, Zimmermann, S, Albrecht, and G, von Gagern

Subjects
Transcription Factor AP-1, Sodium Selenite, Critical Care, NF-kappa B, Down-Regulation, Humans, Systemic Inflammatory Response Syndrome, Up-Regulation
Abstract

Transcription factors adjust the up- and downregulation of inflammatory genes. Within the bounds of the SIC-study (Selenium in Intensive Care) the authors will investigate the role of transcription factors NF-kappa B and AP-1 in S.I.R.S/septic patients. The goal of these investigations is the corroboration of therapy of septic patients with sodium selenite at the molecular biological level.

Published
1999

2. [Significance of selenium in regulation of inflammatory response by transcription factors in polytrauma patients. A clinical study]

Author

G, von Gagern, T, Zimmermann, S, Albrecht, L, Bachmann, H, Zwipp, and H D, Saeger

Subjects
Adult, Male, Survival Rate, Transcription Factor AP-1, Selenium, Sodium Selenite, Treatment Outcome, Multiple Trauma, NF-kappa B, Humans, Female, Systemic Inflammatory Response Syndrome, APACHE
Abstract

The authors have investigated the relationship between selenium and transcription factors (NF-kappa B and AP-1) in the field of pathogenesis of polytrauma. Correlations between plasma selenium content and transcription factor binding activity have been found. The measured connecting capacitances of transcription factors have been associated with the severity of disease. To harden the results of this research a randomized double blind study with sodium selenite substitution is necessary next. This study will be to establish the therapy with sodium selenite in the treatment of polytrauma.

Published
1999

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