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As Warsaw celebrated the 30th anniversary of its liberation from the totalitarian regime by reinvoking the Ciceronian tradition of republican ideal government, Japan found itself in a celebratory mood for the succession of imperial dynasty. Emperor Hirohito (d.1989)’s son was to be replaced by his grandson and thus Japan’s modern invention of an old tradition was to be consolidated. If European modernity has its origins in Renaissance and Reformation (i.e., critical renovation of the past both Classical and Christian) against the backdrop of the benighted Middle Ages, Japan’s modernity, ultimately a result of the emergency measure it took against the great wave of colonization by the west, cannot but be a composite of disparate ingredients. Whereas quick Westernization was prerequisite, equally indispensable was the spiritual consolidation of national identity. And herein comes the idea of renovating the ancient emperorship in a modern mold of absolute monarchy by singling out Shintoism for a kind of national religion: under such circumstances, the doom of Cicero’s reception needs no explanation. But this does not entirely exclude the possibility that an intellectual perspective characteristic of Japanese modernity can contribute to a better understanding of Cicero: where Cicero has been alienated, as indeed he still is, in the main stream of philosophy, the so-called European tradition of metaphysics, Japanese modernity with its inveterate polytheistic background of non-metaphysics has a chance to intervene for hermeneutic negotiations.

Bei der Entstehung von Basalzellkarzinomen (BCC) ist die Interaktion zwischen Hedgehog (Hh)- und Wnt/β-Catenin (Wnt)-Signalwegen untersucht, aber nicht vollständig aufgeklärt worden. Hier wird ein Fall von sporadischem BCC bei einem 80-jährigen Mann vorgestellt, und die Wirksamkeit von SMO-Inhibitoren im Falle eines Rezidivs wird prognostiziert. Ziel dieser Studie war es festzustellen, ob die SMO-Inhibitoren bei der Behandlung dieser Person wirksam sein können, falls der Tumor in der Zukunft wiederauftritt. Immunhistochemische (IHC) Tests wurden an einem Tumor und dem angrenzenden Hautgewebe des Patienten durchgeführt. Die IHC-Tests derselben BCC-Gewebeprobe ergaben, dass GLI1 (Glioma-Associated Oncogene 1) und SMO (Smoothened) im Hh-Signalweg und IGF2BP1 (Insulin-Like Growth Factor 2 mRNA-Binding Protein 1) im Wnt-Signalweg überexprimiert waren. Die Hh- und Wnt-Signalwege waren aktiviert. Diese Befunde deuten darauf hin, dass der Patient aufgrund der Interaktion zwischen den Hh- und Wnt-Signalwegen möglicherweise resistent gegen die Behandlung mit SMO-Inhibitoren ist. Die Überexpression von GLI1 führt zu einer Transkriptionsaktivierung, was es aufgrund der nachgeschalteten Effektoren der Kaskade zu einem attraktiven molekularen Ziel für die Krebstherapie macht. [ABSTRACT FROM AUTHOR]

This paper has attempted to evaluate the radar cross section (RCS) of two furniture items in an indoor environment in a frequency range of 3–7 GHz of the ultra-wideband (UWB) range. The RCS evaluation is achieved through an extended version of the radar equation that incorporates the channel transfer function of scattering. The time-gating method was applied to remove the multipath effect, a phenomenon which typically occurs in the indoor environment. Two double-ridged waveguide horn antennas for both vertical and horizontal polarizations were used to obtain the transfer function of scattering of the furniture prior to analysis in order to derive their bistatic RCS. The RCS results validate the applicability of the proposed extended radar equation to the indoor propagation prediction.

The fine structure of the filamentous and mycelial cell of Endomycopsis fibuliger grown on the agar medium and fixed in osmium tetroxide is described. The cell wall is relatively thick. Of particular interest is the occurrence of numerous vesicles underside of the cell wall proper. They have become dilated frequently at the cell surface, probably as a result of the amylase secretion. The wall presumably is penetrated by plasmodesmata. The plasmodesmata and the intercellular connections are associated with the endoplasmic reticulum. The cytoplasmic matrix is generally granular and contains nonmembrane-limited patches of lipoid. Mitochondria are numerous and variable in shape, and have been observed in different stages of development. The mitochondria profiles are delimited from the surrounding cytoplasm by single or sometimes double electron-dense lines. The double dark lines of a unit membrane at the nuclear surface are not always clear. [ABSTRACT FROM AUTHOR]

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