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Your search keyword '"TETRALONES"' showing total 10 results
Start Over Descriptor "TETRALONES" Language german
10 results on '"TETRALONES"'

1. [Polarography of 2-benzylidenetetralone-(1)]

Author

P, Pflegel, A M, Murach, and H J, Hofmann

Subjects
Spectrophotometry, Infrared, Methods, Spectrophotometry, Ultraviolet, Hydrogen-Ion Concentration, Benzylidene Compounds, Polarography, Tetralones
Published
1977

2. [On the pharmacology of the alpha-receptor blocker BE 2254 (HEAT) (author's transl)]

Author

N, Heinz and E, Hofferber

Subjects
Male, Reserpine, Tetrahydronaphthalenes, Muscles, Guinea Pigs, Blood Pressure, Muscle, Smooth, Naphthalenes, Receptors, Adrenergic, alpha, Myocardial Contraction, Rats, Norepinephrine, Phenethylamines, Synapses, Animals, Adrenergic alpha-Antagonists, Muscle Contraction, Tetralones
Abstract

The alpha-adrenolytic activity of BE 2254 was investigated in in vitro as well as in vivo assays. On the isolated rat anococcygeus muscle, 2-[beta-(4-hydroxyphenyl)-ethyl-amino-methyl]tetralone(1) (BE 2254) shows a high affinity for postsynaptic alpha-adrenoceptors (pA2 = 8.9), in contrast to its much weaker potency (pA2 = 6.7) in inhibiting clonidine on the electrically driven rat vas deferens, thus suggesting a relative preference for postsynaptic alpha-adrenoceptors. BE 2254 effects on other catecholamine receptors are either negligible or not detectable. The hypotensive action of BE 2254 is shown to be solely due to alpha-blockade. All alpha-adrenolytic actions studied were of competitive nature.

Published
1980

6. [Polarography of 2-benzylidenetetralone-(1)].

Author

Pflegel P, Murach AM, and Hofmann HJ

Subjects
Hydrogen-Ion Concentration, Methods, Polarography, Spectrophotometry, Infrared, Spectrophotometry, Ultraviolet, Tetralones, Benzylidene Compounds analysis
Published
1977

7. [On the pharmacology of the alpha-receptor blocker BE 2254 (HEAT) (author's transl)].

Author

Heinz N and Hofferber E

Subjects
Animals, Blood Pressure drug effects, Guinea Pigs, Male, Muscle Contraction drug effects, Muscle, Smooth drug effects, Muscles innervation, Myocardial Contraction drug effects, Norepinephrine pharmacology, Rats, Receptors, Adrenergic, alpha drug effects, Reserpine pharmacology, Synapses drug effects, Adrenergic alpha-Antagonists pharmacology, Naphthalenes pharmacology, Phenethylamines pharmacology, Tetrahydronaphthalenes pharmacology, Tetralones
Abstract

The alpha-adrenolytic activity of BE 2254 was investigated in in vitro as well as in vivo assays. On the isolated rat anococcygeus muscle, 2-[beta-(4-hydroxyphenyl)-ethyl-amino-methyl]tetralone(1) (BE 2254) shows a high affinity for postsynaptic alpha-adrenoceptors (pA2 = 8.9), in contrast to its much weaker potency (pA2 = 6.7) in inhibiting clonidine on the electrically driven rat vas deferens, thus suggesting a relative preference for postsynaptic alpha-adrenoceptors. BE 2254 effects on other catecholamine receptors are either negligible or not detectable. The hypotensive action of BE 2254 is shown to be solely due to alpha-blockade. All alpha-adrenolytic actions studied were of competitive nature.

Published
1980

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