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Although the incidence of bladder cancer among women is lower, they tend to more often have advanced disease at presentation with a more aggressive course. It is still unclear which factors are responsible for the poorer prognosis of bladder cancer in women.Original papers and reviews from 2004 until 2022 were identified in a PubMed search and evaluated.Multiple factors are likely responsible for the different courses of bladder cancer in women versus men. In the literature, epidemiologic and clinical aspects are discussed. Furthermore, genetic and hormonal causes and the role of the urobiome have been the focus of discussion more recently.Earlier diagnosis and better surgical treatment could lead to a more favorable course of bladder cancer in women. Further analyses of genetic, hormonal, und microbiological factors could open new perspectives in the prevention, diagnosis, and treatment of bladder cancer.HINTERGRUND UND FRAGESTELLUNG: Frauen erkranken seltener an einem Harnblasenkarzinom, sind jedoch häufiger von fortgeschritteneren Tumorstadien und ungünstigeren Krankheitsverläufen betroffen. Es ist bis heute unklar, welche Ursachen für den aggressiveren Verlauf des Harnblasenkarzinoms bei der Frau verantwortlich sind.Mittels einer PubMed-Recherche wurden Original- und Übersichtsartikel in einem Zeitraum von 2004 bis 2022 ausgewertet.Es ist am ehesten von einer multifaktoriellen Genese auszugehen. In der Literatur werden v. a. epidemiologische und klinische Aspekte als mögliche Ursachen genannt. Ferner werden in letzter Zeit zunehmend auch genetische und hormonelle Faktoren sowie die Rolle des Urobioms diskutiert.Durch eine frühere Diagnosestellung und bessere operative Therapie kann der onkologische Verlauf der Harnblasenkarzinomerkrankung der Frau günstig beeinflusst werden. Weitere Analysen der genetischen, hormonellen und mikrobiologischen Faktoren könnten neue Wege in der Prävention, Diagnostik und Therapie des Harnblasenkarzinoms eröffnen.

Zusammenfassung Die Studie LIFE Child Psychische Entwicklung/Depression ist eine prospektive Längsschnittstudie zu Entstehung und Verlauf von depressiven Symptomen und Störungen von der Kindheit bis in das Erwachsenenalter. Ziel der Studie ist es, Symptom- und Störungsverlaufsmuster zwischen Kindheit und Erwachsenenalter zu identifizieren und das Zusammenspiel von psychosozialen, biologischen und genetischen Risiko- und Schutzfaktoren bei der Entwicklung von depressiven Störungen zu untersuchen. Der vorliegende Beitrag möchte eine Übersicht über bisherige Befunde der Längsschnittstudie geben. Die bereits dreimal ausführlich untersuchte Stichprobe setzt sich aus einer in den Leipziger kinder- und jugendpsychiatrischen Kliniken rekrutierten Stichprobe und einer Bevölkerungsstichprobe zusammen. In unseren verschiedenen Teilstudien fanden wir Belege für diverse kontext-, eltern- und kindbezogene Risikofaktoren, darunter belastende Lebensereignisse, geringer sozioökonomischer Status und Depressivität der Mutter (nicht aber des Vaters). Zudem fanden wir einige charakteristische biologische und kognitiv-emotionale Merkmale von Kindern mit depressiven Störungen, wie eine geringere Cortisolausschüttung, eine geringere Einschätzung der eigenen Leistung und mehr negative Gedanken im Umgang mit anspruchsvollen Situationen, einen geringeren Selbstwert sowie eine generelle Beeinträchtigung in der emotionalen Verarbeitung menschlicher Gesichter. Nur wenige der gefundenen Faktoren stellen im engeren Sinne depressionsspezifische Risikofaktoren dar, sondern sind stattdessen als allgemeine Risikofaktoren für psychische Störungen im Kindesalter anzusehen. Bemerkenswert ist des Weiteren die Geschlechtsspezifität mancher Zusammenhänge, die einen differenzierten Blick auf Risikozusammenhänge erforderlich macht. Vor diesem Hintergrund ergeben sich aus unserer Studie mögliche Ansatzpunkte für Prävention und für die Therapie depressiver Kinder.

Compared to other illicit drugs Methamphetamine (MethA) is used more frequently by women than by men. Assuming the biopsychosocial etiology model, the dependency is based on several factors in which women and men differ significantly. Systematic gender-differentiated knowledge is missing until today.Based on a database research (PUBMED) the review examines biological, social and psychological as well as therapeutic aspects in MethA-dependent women.MethA-induced cognitive disturbance appear to have severer manifestations in women than in men. MethA-addicted women's lifestyle is often characterized by active and passive (sexualized) violence. They show an increased risk behavior; i. e. unprotected sexual intercourse with several partners. Their psychological comorbidities seem to be more pronounced and especially affect anxiety disorders and depressive syndromes.In women, abuse and dependence of MethA are determined by psychological as well as social factors. However, further research is needed to improve prevention, counseling and therapy.Methamphetamin (MethA) wird im Verhältnis zu anderen illegalen Drogen tendenziell häufiger von Frauen als Männern konsumiert. Unter Annahme des bio-psycho-sozialen Ätiologie-Modells beruht die Abhängigkeit auf biologischen, psychischen und sozialen Faktoren, in denen sich Frauen und Männer unterscheiden. Systematische genderdifferenzierte Erkenntnisse, die einen wichtigen Einfluss auf therapeutische Maßnahmen haben, fehlen allerdings noch.Die Übersicht basiert auf einer Datenbank-Recherche (PUBMED) zu biologischen, psychischen, sozialen sowie therapeutischen Aspekten bei von MethA abhängigen Frauen.MethA-induzierte kognitive Störungen scheinen bei Frauen stärker ausgeprägt zu sein als bei Männern. Ihr Lebensstil ist oft von aktiver und passiver (sexualisierter) Gewalt geprägt. Sie zeigen ein erhöhtes sexuelles Risikoverhalten; v. a. durch ungeschützten Verkehr mit mehreren Partnern. Psychiatrische Komorbiditäten scheinen quantitativ ausgeprägter zu sein und betreffen v. a. Angststörungen und depressive Syndrome.Missbrauch und Abhängigkeit von MethA werden bei Frauen von psychischen als auch sozialen Faktoren determiniert. Es bedarf aber weiterer gendersensibler Forschungen, um die Prävention, Beratung und Therapie zu verbessern.

This article presents the normative data for flow density measured using optical coherence tomography (OCT) angiography and the impact of age and gender is evaluated.In this study 58 eyes from 58 healthy volunteers with no history of any ocular disease or ocular surgery were included. The OCT angiography imaging was performed using the RTVue XR Avanti with the AngioVue (Optovue, Fremont, CA). The macula was imaged using a 3 × 3 mm scan, and the flow density data in the superficial retinal OCT angiogram and deep retinal OCT angiogram were extracted and analyzed. The groups were compared using the Mann-Whitney U‑test and the degree of correlation between two variables was expressed as the Spearman's correlation coefficient (rSp.) RESULTS: The mean subject age was 38.3 ± 14.6 years. The flow density (whole en face) in the deep retinal OCT angiogram was significantly higher compared to the flow density in the superficial retinal OCT angiogram (p 0.001). There was no significant difference in the mean flow density in superficial and deep OCT angiograms of the macula between males (n = 27) and females (n = 31). There was a significant correlation between the flow density in the deep retinal OCT angiogram and age (rSp. = -0.41, p = 0.001).Whereas gender has no impact on the flow density measured using OCT angiography, there was a significant correlation between the flow density in the deep retinal OCT angiogram and age.

The study aimed to validate the German version of the revised Trauma Symptom Inventory (TSI-2) by John Briere. TSI-2 assesses complex posttraumatic stress symptoms. In order to validate it, further instruments were applied, namely the Adverse Childhood Experience Scale, the CIDI list, the revised Impact of Event-Scale, the interview for complex posttraumatic stress disorder, the revised symptom checklist 90, the dissociative experiences scale, the inventory for interpersonal problems, and the self-efficacy questionnaire. The participants were N=100 traumatized psychiatric in-patients of a psychiatric hospital localized in the German-speaking part of Switzerland. The sample consisted of N=42 women. The study design was longitudinal with 2 assessments. The second assessment took place 4 weeks after the first, in order to investigate retest reliability. Here, N=17 patients participated, of whom N=8 were women. Regarding the results, on average, 3.5 aversive or traumatic experiences during childhood were reported, and 2,1 during adulthood. The diagnosis of (classical) PTSD was estimated at 33%. The results indicate that TSI-2 is both reliable and valid with respect to different criteria: Most scales and subscales of the TSI-2 showed acceptable to very good internal consistencies (α from 0.73 to 0.95) as well as good discriminatory power, and an acceptable retest reliability. Results also indicate good divergent and convergent construct validity as well as good criterion validity. It was not possible to replicate the 4-factor-model presented by the original author of the TSI-2. Instead, in line with the study that validated the German translation of the first version of the TSI-1, a 2-factor-model was found. There were gender differences regarding the TSI-2 scales with higher posttraumatic stress symptoms in women. In conclusion, there is evidence that indicates that the German translation of the TSI-2 is a reliable and valid instrument for the assessment of complex posttraumatic stress symptoms.

Sport is highly relevant in the life of boys and young men. It is not only one of the most common and important leisure activities, but also helps male self-assurance through physical conflicts and competitions as well as through physical proximity and social involvement. At the same time, sport is an ambivalent area that preserves health, but can also be dangerous to it. By considering the development of male identity, the specific possibilities of sport, as well as an overview of the health situation of boys, this article develops starting points for lifestyle-oriented health promotion of boys and young men in the area of exercise, games and sport. In sports, physical practices are learned that can have long-term effects as somatic cultures on health behavior. The work with boys in sports can be health-promoting if opportunities and risks are reflected upon and considered in the didactic planning and execution.

There are nutritional differences between the sexes: eating behavior in men is often rated as "unhealthy" compared with that in women. Nutrition in men and women is rather more of an expression of social gender roles and expectations than biologically determined. Meat and alcohol, for instance, are regarded as "powerful" foods and thus have masculine connotations. Fruit and vegetables, on the other hand, are considered "weak" and therefore feminine foods. This overlooks the fact that a "typically" female diet is often oriented toward attractiveness and is associated with restricted eating behavior. The so-called "healthier" nutrition of women is also accompanied by greater nutritional knowledge and competence. However, it needs to be questioned whether male family or household members are absolved from responsibility for their own health or whether they are happy to leave this to women because of the socially perceived feminine responsibility for all aspects of nutrition, sustenance and care-giving. The advanced knowledge and competence of women in questions of healthy eating and food preparation compared with men often act as an obstacle to men engaging and actively participating in nutritional issues.Emphasizing the observed gender differences is not expedient in terms of effective communication on nutrition and health and can run the risk of reproducing gender stereotypes and neglecting other more powerful social categories. Alternative strategies consist of focusing more on the "eating person" and following a gender-neutral communication and counseling strategy.

The introduction of genome-wide association studies resulted in a tremendous increase in the number of genes associated with obesity and related phenotypes (BMI, waist and waist-hip-ratio). Despite this enormous gain in knowledge the search for genes is only started since only a small fraction of the heritability of these phenotypes is explained yet: each single gene of the 97 hitherto known BMI-associated genes and 49 waist-hip-ratio-associated genes explains only a tiny fraction of the variance of these phenotypes. Sex-specific differences are mainly known for waist-hip-ratio and ̴40% of the genes showed only an effect in women but no or a markedly smaller effect in men. The functional characterization of the identified genes will take a lot of time. It is unclear whether and how fast the findings will result in therapeutic consequences. It is of utmost importance that we understand the involved mechanisms before new therapeutic strategies can be developed.

Efforts to optimize the diet in terms of prevention and treatment of obesity aim at long-term adaptation and reduction of energy intake according to age and physiological requirements while preserving the nutrient density with consideration of individual food preferences.As the nutritional habits of the average Austrian people are unfavorable for obesity prevention there is a clear need for action. Women are "disadvantaged" in weight control compared to men in terms of physiological conditions-and are confronted with specific needs during life course (e.g. pregnancy), whereas the average man or male adolescents present "unhealthier" behaviors and attitudes and are (still) less interested on nutrition or weight control.To achieve better nutrition a target-group specific, gender-sensitive guidance of the individual is needed, starting with pregnant women, but also habitat-oriented interventions for improved nutrition offers, which have to be sustainably assured through the support of a relevant legal and social framework.

Eating behavior and physical activity behavior are under the control of certain cognitive patterns. 6600 adults and 4400 children/adolescents (8-18 years) were tested with the Obesity Diagnostics and Evaluation System (AD-EVA). Potentially significant gender differences will be detailed for the entire juvenile cohort, the subgroup of obese children/adolescents as compared to the adult cohort in this article.Among all the subscales tested, obese girls primarily showed significantly higher values of (preclinical) eating disorders than boys. These data are relevant for both prevention and health promotion.No significant differences were found in regard to sports motivation. This warrants facilitation of physical activity for both genders. Further, a male predilection for "Snacks" and "High-fat food" that could be found in the total representative study group, could not be verified in the subgroup of obese girls and boys, thus suggesting a similarily unhealthy eating behavior in both genders of juvenility.

Men have not been the focus of health monitoring and reporting in German-speaking Switzerland so far and are a largely neglected target group of governmental preventive efforts. Without good reason. Men have a substantial preventive potential regarding health, health behavior and use of health and medical services, as can be seen in the recently published global health report of the Canton Zurich. Men have a shorter life expectancy compared to women and a significantly higher mortality with regard to strongly behavior-related chronic diseases as well as fatal traffic accidents and suicides. Men also show comparably unfavourable health behavior and a reduced utilization of health services. The stronger, but also less healthy and less healthy behaving sex should increasingly be the focus of health reporting and health monitoring in the future.

The skull presents a variety of morphological traits suitable for sex discrimination due to the degree of their development. The vertical frontal inclination has been established. as another marker of sex discrimination, as a steep forehead is considered as a female and a receding frontal inclination as a male attribute. In the literature, there are many different ways to define the morphognostic term "frontal inclination" and "forehead profile" respectively. As part of the project "Digital Forensic Osteology" definitions of the frontal inclination commonly found in the literature have been tested with regard to their applicability to virtual skulls based on post-mortem CT data. The actual angle measurements were carried out automatically using software developed by the authors of this article. For the investigations, profile images of skulls generated from volume-rendered CT data were used in which anthropometric measuring points had been set manually. With the help of discriminant analysis it was tested whether sex discrimination on virtual skulls based on defined variables can be carried out with sufficient sensitivity. The measurement accuracy of the defined variables on the volume-rendered images turned out to be good. No significant sex differences regarding the tested variables were found. Using all the four selected variables the sensitivity for female skulls was only about 66%, whereas for male skulls it was not much higher than the rate of coincidence (53%). The results of this pilot study suggest that apart from extending the sample size the inclusion of additional variables based on strict consideration of validity and reliability criteria should be critically tested.

Contact allergy to several non-related haptens, usually termed polysensitization (PS), is often used to characterize patients who are particularly prone to sensitization. A conventional definition for PS is positive reactions to three or more haptens of the baseline series, e.g., the baseline series of the German Contact Dermatitis Research Group. Previous genetic as well as epidemiological studies have already indicated a number of potential risk factors for PS. In this context, both endogenous as well as exogenousfactors appear to be crucial. The former comprise polymorphism of IL-16 and TNF coding genes, the latter mostly occupational exposure, which often entails intense and repeated skin contact to a set of more or less characteristic contact allergens. Moreover, age and sex are related both with contact allergy to certain substances and with PS, as is the anatomical site of contact dermatitis. The degree to which contact allergy to a specific hapten is associated with PS, i.e., with contact allergy to several other haptens, varies greatly.

This review focuses on the gender and sex dimorphic disease profile and treatment reality of patients suffering from inflammatory bowel diseases (IBD). It provides an overview of gender-specific differences in the disease course, medical and surgical therapy as well as psychosocial aspects of IBD.

Gastroesophageal reflux disease (GERD) is highly prevalent in the Western world. Patients with GERD have a 10 fold increased risk to develop a Barrett's esophagus. Patients with Barrett's esophagus have a higher risk for an esophageal adenocarcinoma. Men have more severe reflux with a higher grade of inflammation and acid reflux. This seems to be the reason why men develop a Barrett's esophagus more frequently--the risk is approximately 2 to 3 fold and the risk for an esophageal adenocarcinoma is even 3 to 6 times higher.

The incidence of colorectal cancer worldwide is higher in men. Risk factors like smoking, overweight, or dietary exposures cannot explain this gender difference. In the pathogenesis of colorectal carcinoma, estrogen seems to play an important protective role. Estrogen may reduce the risk of developing colon cancer in premenopausal women. The expression of estrogen receptor ß in healthy colon is significantly decreased in the development of colon cancer. The role of estrogen in pathogenic pathways is most likely protective or might serve as a tumor suppressor. However, the exact role of estrogen in the carcinogenesis of colorectal cancer still remains unclear. Furthermore, tumor localization depends on age and gender. Therefore, in postmenopausal women there is a shift to predominantly right-sided cancers. Here, a link between tumor localization and MSI-H (microsatellite-high) status can be assumed. There are virtually no prospective randomised trials in adjuvant or palliative therapy of patients with colorectal cancer. Earlier data from registries point to a better post-operative survival of women, while men seem to benefit more from adjuvant therapy. Potentially, there may be a role of an increased toxicity to 5-FU in women. In the palliative setting, there are also only few gender-specific analyses. Women with right-sided colon cancers show a significant worse response and survival under an anti-EGFR antibody treatment compared with men and left-sided cancers. A focus on gender-specific differences should be incorporated more often in future randomised trials.

Approximately 3-5% of all colorectal cancers are based on a hereditary predisposition, of which Lynch syndrome is by far the most frequent hereditary cancer syndrome. Beside colorectal cancer Lynch-Syndrome is the most frequent predisposing hereditary cause of endometrial cancer and is also associated with gastric cancer, ovarian cancer, cancer of the urinary tract as well as several other cancers. Genetically Lynch syndrome is caused by a germline mutation in one of the so-called mismatch-repair-genes. Based on several epidemiological studies, increasingly differences in the penetrance of the different cancers occurring are associated with the affected gene and also gender of the patient have been reported. The lifetime risk of colorectal cancer for males with Lynch syndrome generally is significantly higher and the age of first manifestation significantly earlier compared to females. The difference is especially notable in men with a MSH6-mutation. Moreover, the lifetime risk for gastric, bladder, and urothelial cancer is much higher in males. Women with an MSH6 mutation have a much higher risk for endometrial (and ovarian) cancer than for colorectal cancer. In patients with Muir Torre syndrome again males are predominantly affected and almost all affected have a mutation in MSH2 rather than in any other MMR gene. This review is an update of the literature analyzing gen and gender specific aspects of Lynch syndrome. To date these associations are based on retrospective studies, that require confirmation in a prospective setting with large patient numbers in order to identify validated, individualized gene and gender screening recommendations in the future. Especially in a syndrome with multiple potential cancer targets, an intense yearly program comprising several invasive procedures has a negative effect on patient compliance.

Cultural setting and sex and gender of the patient are important factors affecting the occurrence, severity, clinical course and prognosis of pain and pain-related diseases. Intercultural differences in the perception and verbal expression of symptoms and emotional function are fundamental and it is important to realize these differences in order to understand patients with a migration background. A trusting doctor-patient relationship is generally very sensitive and it is even more difficult to establish when differences in the cultural background impair mutual understanding. Regarding sex and gender there is evidence that females are more susceptible to developing chronic pain conditions, experience more severe pain and respond differently to pain therapy; however, results of recent studies indicate that females are not that different to males when comparing several modalities of experimental pain (although some differences exist). Similarly, sex and gender differences in postoperative pain seem to exist but the differences are relatively small when pain scores are compared. Other aspects, such as the response to analgesics and role of psychosocial factors should be addressed when sex and gender aspects are studied. Similarly, sex and gender differences in the prevalence of chronic pain exist but the results of some studies, e.g. those controlling for confounders, are not very clear. Research is needed to delineate the role of specific aspects affecting sex and gender differences and the underlying mechanisms (e.g. reduced inhibitory control, hormones, psychological aspects and social factors). Altogether, we need to open our minds to some intercultural and sex and gender aspects in the clinical setting. For sex and gender differences we may need a more biopsychosocial approach to understand the underlying differences and differentiate between sex and gender and sex and gender-associated aspects for acute and chronic pain.

Studies in mice indicate gender-specific differences in surgical complications with a distinct advantage for females. In patient care, however, gender has been an underrated aspect of complication management in abdominal surgery as far. Proven differences between the sexes regarding anatomy, hormonal regulation, constitutional polymorphisms, immune response and psychology suggest different types and incidence of complications and seem to justify studies on the topic. This review aims to compare a selection of current original articles reporting on complications following abdominal surgery separately for the genders. However, data in the literature are sparse and in part very heterogeneous. With data on colorectal carcinoma being most comprehensive, for stomach, oesophagus and finally pancreas fewer data can be found. Summing up all organ systems, the following cautious conclusions can be drawn. Men tend to suffer from postoperative complications more frequently. Men have more cases of anastomotic leakage, whereas women suffer from anastomotic stenosis more often. Currently, however, existing data do not justify any adaptation of patient management. Thus, taking gender aspects into account in designing new trials is paramount in order to obtain robust gender-specific data on incidence and types of complications.

Liver transplantation is the treatment of choice for acute hepatic failure or endstage liver disease. Long-time outcome following liver transplantation has been increased as a result of improvements in surgical technique, perioperative management, organ procurement and immunuosuppression. Differences in liver disease, access and allocation to liver transplantation as outcome due to gender have been reported. This review highlights the important differences in the field of liver transplantation.

The current situation in obesity and metabolic surgery since January 2005 has been investigated with the help of the quality assurance study on surgical therapy for obesity = German Bariatric Surgery Registry (GBSR). The data were acquired and analysed in cooperation with the Institute for Quality Assurance in Surgical Medicine at the Otto-von-Guericke University.Data acquisition was done with the help of an online database. On a voluntary basis, all obesity and metabolic surgical interventions since 2005 have been recorded. In addition to the surgical data, the findings of the yearly follow-up investigations were recorded.Since 2005 there have been 1,263 gastric balloon procedures, 11,840 sleeve gastrectomies, 13,722 Roux-en-Y gastric bypasses and 3999 gastric banding operations. The average age of the male patients in all interventions was significantly higher. The average BMI of female patients who received a gastric banding or a gastric balloon procedure was significantly lower than that of the male patients. Men exhibited a higher incidence of comorbidities than women.The number of obesity and metabolic surgical interventions in Germany is continuously increasing. The results of the study on surgical therapy for obesity (GBSR) reveal significant differences in the gender-specific incidence of preoperative comorbidities. postoperative complications and mortality. Further studies on gender-specific aspects are necessary in order to optimise patient selection and reduce the incidence of postoperative complications.

More and more women suffer from lung cancer. In comparison to the male patients they are younger and more likely never-smokers. Adenocarcinomas are more frequently in women than in men. Their long-time survival post curative resection in early stage non-small-cell lung cancer is better than in men. Women show frequently more molecular changes: more molecular targets are found. Therefore they might benefit more from target-oriented stratified medical treatments. This overview comments on the gender-specific differences in diagnostics, treatment and outcome of lung cancer.

Maladaptive reactions on stressful experiences justifying a diagnosis of adjustment disorder have high prevalence. Little is known about the possible risk for clinically significant maladaptation that results from the social context. The literature on the effects of depression on communication and altered support conditions in couples is suggesting this. Aim of this study was to investigate whether clinically significant depression in the romantic partner is a risk factor for adjustment disorder following a concept of stress-response disorder. Furthermore, from a dimensional point of view a possible positive association between depressive symptoms in the partner and own adjustment symptom was studied. Thereby, own depressive symptoms were controlled for in order to exclude mere depressive contagion and isolate stress-related responses. In an online-couple-study N=294 participants (N=147 couples) reported whether or not they had experienced a stressful event that is still bothering them. N=152 participants reported such an event. N=28 of this group reached the threshold of a possible diagnosis with the screening questionnaire "Adjustment disorder New Module". N=14 romantic partners reported depressive symptoms above the cut-off of the CES-D. The risk for an adjustment disorder is elevated if the female partner reports a clinically significant level of depressive symptoms (OR 7.13). This was only true when female partners were depressed, the depression of male partners did not show any significant associations. Accordingly, dimensionally there is a positive association between depressive symptoms of the female partner and adjustment symptoms of preoccupation (stressor-related repetitive negative thoughts). Depression of the romantic partner seems to be a significant risk factor for maladaptive reactions on a stressful event. This was particularly true for male participants of the study. To sum up, results encourage taking up an interpersonal perspective in research and clinical interventions.

Maladaptive reactions on stressful experiences justifying a diagnosis of adjustment disorder have high prevalence. Little is known about the possible risk for clinically significant maladaptation that results from the social context. The literature on the effects of depression on communication and altered support conditions in couples is suggesting this. Aim of this study was to investigate whether clinically significant depression in the romantic partner is a risk factor for adjustment disorder following a concept of stress-response disorder. Furthermore, from a dimensional point of view a possible positive association between depressive symptoms in the partner and own adjustment symptom was studied. Thereby, own depressive symptoms were controlled for in order to exclude mere depressive contagion and isolate stress-related responses. In an online-couple-study N=294 participants (N=147 couples) reported whether or not they had experienced a stressful event that is still bothering them. N=152 participants reported such an event. N=28 of this group reached the threshold of a possible diagnosis with the screening questionnaire "Adjustment disorder New Module". N=14 romantic partners reported depressive symptoms above the cut-off of the CES-D. The risk for an adjustment disorder is elevated if the female partner reports a clinically significant level of depressive symptoms (OR 7.13). This was only true when female partners were depressed, the depression of male partners did not show any significant associations. Accordingly, dimensionally there is a positive association between depressive symptoms of the female partner and adjustment symptoms of preoccupation (stressor-related repetitive negative thoughts). Depression of the romantic partner seems to be a significant risk factor for maladaptive reactions on a stressful event. This was particularly true for male participants of the study. To sum up, results encourage taking up an interpersonal perspective in research and clinical interventions.

An increasing incidence of chronic immune diseases such as allergies, multiple sclerosis, and type 2 diabetes, as well as obesity and cardiovascular and psychiatric disorders has been reported over the last five decades. Since the human genome has not altered significantly over this period of time, gene-environment interactions are suspected to be responsible for these increased disease incidences. In this context, the prenatal period is believed to significantly contribute to altered disease susceptibilities, which could be associated with environmental factors to which pregnant women were exposed to. This observation has led to a concept entitled 'developmental origin of health and disease', a topic that is enjoying much attention in clinical and basic science research. The aim of these research endeavors is to postulate guidelines for primary disease prevention. Whilst the emerging insights from this field of research provide significant pieces of the puzzle, one area is still largely neglected: the clear identification of a sex-specific programming effect. Thus it is essential that such an approach becomes fully integrated in future research goals.

Sex-specific differences in the prevalence and severity of immune disorders are well-known phenomena; however, it is only recently that we have begun to understand the possible causes of such differences.A literature search on this topic was carried out and the results are summarized.In the last few years research has been guided by technological advances in gene sequencing and new insights into the microbiome of the gut, as well as an awareness of sex- and gender-specific risk factors for infections and autoimmunity.The knowledge acquired in recent years will not only improve diagnostics and early identification of these disorders but also influence future research, prevention and therapy of infections and autoimmune diseases.