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Mycotic keratitis is a serious but relatively rare disease. No targeted data collection in Germany existed until the foundation of the German Pilz-Keratitis Register in 2015.The inclusion of retrospective and prospective patients was carried out.diagnosis confirmed by the polymerase chain reaction (PCR), culture, histology or confocal microscopy (IVCM). Collected parameters: date of symptom onset, date and method of diagnosis, risk factors, visual acuity and findings at admission and at follow-up, conservative and surgical treatment.By January 2018, a total of 102 eyes from the years 2000-2017 were reported from 16 centers (64.3% female, mean age 52 years, range 18-95 years). The initial diagnosis was made correctly in only 20.6% of cases. The mean time to correct diagnosis was 31.7 ± 46.9 (0-296) days. The diagnosis was confirmed in cultures in 74.5%, histologically in 30.4%, by PCR in 38.2% and IVCM in 27.4%. Fungal species identified were: 36.7% Fusarium spp., 35.8% Candida spp., 6.4% Aspergillus spp. and 21.1% other. The most important risk factor was the use of contact lenses. The most commonly used antifungal agent was voriconazole (64.7%) followed by amphotericin B (37.2%). Penetrating keratoplasty was performed in 65.7% of the cases and 8.8% of the affected eyes had to be enucleated. The visual acuity of the entire study population increased from the initial 0.16 ± 0.25 (0.001-1.0) decimal to 0.28 ± 0.34 (0-1.0) decimal.The correct diagnosis of fungal keratitis is often significantly delayed. The treatment can be very difficult and keratoplasty is often necessary. In order to gain a better understanding of this disease, to recognize previously unknown risk factors and, if necessary, a change in the spectrum of pathogens and to identify approaches to treatment optimization, the fungal keratitis registry will be continued.

Fragestellung: In dieser intra- individuellen Untersuchung wird im Rahmen der Kataraktoperation ein geringgradiger Astigmatismus entweder mittels Implantation der torischen IOL der Firma AMO (Tecnis Toric ZCT00) oder mittels LRI’s korrigiert. Methodik: Die Studie umfasst 10 Augenpaare mit[for full text, please go to the a.m. URL], 27. Kongress der Deutschsprachigen Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie (DGII)

VKHS is an inflammatory system disease with a subacute chronic course. It has a very variable, selective involvement of certain pigment cells of the eye, skin, inner ear, and meninges. Due in part to the fact that its symptoms are responsive to immunosuppressive therapy, pathogenesis as an autoimmune disease is considered. The clinical course of one of our patients is discussed. Early diagnosis of VKHS, although often very difficult, is mandatory for appropriate and timely treatment.

Proteolytic activity of psychotrophie bacteria in milk can be measured in a practical and comparatively sensitive manner using Azocasein as a substrate. The necessary parameters were exemplarily developed and demonstrated with a typical, strongly proteolytic strain of Pseudomonas fluorescens (No. 112). Comparison of the improved Azocasein method with a modified version of the HPA method of Cliffe and Law--they had proposed it for predicting the stability of UHT milk--showed nearly the same sensitivity with six test strains of Pseudomonas fluorescens. The first significant detection of proteolytic activity could be made approximately at the same time except with one strain of the biotype II (miscellaneous strains). It is discussed, whether the demonstrated methods can be judged (by the bacterial counts of detection) as sufficiently sensitive for to prediction of term spoilage during storage of UHT products.