1. 10E,12Z-9-Hydroxy-10,12-Octadecadiensäure, ein Aromatase-Hemmstoff aus dem Wurzelextrakt von Urtica dioica
- Author
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Wilfried Bartsch, Rupert Kraus, Gerhard Spiteller, and Publica
- Subjects
stinging mettle root extract ,medicine.drug_class ,hydroxy fatty acid ,root extract ,Brennesselwurzelextrakt ,chemistry.chemical_compound ,Lipoxygenase ,medicine ,aromatase inhibition ,Physical and Theoretical Chemistry ,Aromatase ,Derivatization ,Urtica dioica ,chemistry.chemical_classification ,Aromatase inhibitor ,biology ,Organic Chemistry ,biology.organism_classification ,Hydroxyfettsäure ,Urticaceae ,Enzyme ,chemistry ,Biochemistry ,Enzyme inhibitor ,biology.protein ,Wurzelextrakt ,Aromatasehemmung - Abstract
(10E,12Z)-9-Hydroxy-10,12-octadecadienoic Acid, an Aromatase Inhibitor from Roots of Urtica dioica Aqueous-methanolic extracts from roots of Urtica dioica were fractionated and tested for aromatase-inhibition activity. After derivatization the most active fraction was separated by GC/ MS. Besides common fatty acids (10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (1) was identified as a main component and confirmed to be the active principle. Lipoxygenase from tomatoes was used for synthesis of (9S)-1, which caused also inhibition of aromatase. Stereo models of the compound showed some structural similarity to steroidal natural substrates of aromatase. For that reason (10E,12Z)-9-oxo-10,12-octadecadienoic acid (2) was also synthesized. It showed an about tenfold higher activity compared to 1.
- Published
- 1991