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Start Over Descriptor "Receptors, GABA-A analysis" Language german
1 results on '"Receptors, GABA-A analysis"'

1. [Comparison of blood flow and benzodiazepine receptor distribution in focal epilepsy: preliminary results of a SPECT study].

Author

Bartenstein P, Ludolph A, Schober O, Lottes G, Böttger I, and Beer HF

Subjects
Adult, Aged, Brain diagnostic imaging, Brain Mapping, Female, Humans, Male, Middle Aged, Radioligand Assay, Epilepsies, Partial diagnostic imaging, Receptors, GABA-A analysis, Tomography, Emission-Computed, Single-Photon
Abstract

99mTc-HMPAO-SPECT and SPECT with the 123I-labelled benzodiazepine (Bz) receptor ligand Ro 16-0154 were performed in 10 patients suffering from partial epilepsy, without cerebral lesion in MRT or CT.2 h p.i. of Ro 16-0154 the distribution of activity correlated with the known distribution of Bz-receptors in the human brain. Perfusion and receptor-binding were found decreased in 7 patients of each study in the suspicious brain-area. 123I-labelled Ro 16-0154 is suitable for Bz-receptor mapping by SPECT. The decrease of Bz-receptor binding in epileptic foci, as described in PET-studies, was also detected by SPECT in 7 of 10 patients.

Published
1989

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