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Start Over Descriptor "Receptors, Dopamine D2 chemistry" Language german
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1. [Indoles. 10. Synthesis, structure and D2-affinity of beta-carboline analogs of flutroline].

Author

Lehmann J, Knoch F, and Jiang N

Subjects
Antipsychotic Agents pharmacology, Carbolines chemical synthesis, Carbolines pharmacology, Molecular Conformation, Receptors, Dopamine D2 chemistry, Structure-Activity Relationship, Antipsychotic Agents chemistry, Carbolines chemistry, Dopamine D2 Receptor Antagonists
Abstract

10 is a beta-carboline analogue of the neuroleptic flutroline2a,b) with significant lower affinity at the dopamine D2 binding site. Various synthetic routes to 10 and the solid state structure of 8 are described, structure activity relations, in particular the importance of the "S-shape" and the rigid dopamine conformation are discussed.

Published
1993
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