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Fragestellung: Der Murphy Roths Large Mausstamm (MRL) hat in vergangenen Studien mehrfach eine im Vergleich zu anderen Mäusen verbesserte Sehnenheilung gezeigt und wird deshalb als "super-healer" Stamm bezeichnet. Untersuchungen der Regenerationsmechanismen der MRL-Mäuse warfen eine [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Fragestellung: Die narbige Sehnenausheilung stellt auf Grund biomechanischer Einbußen ein erhebliches klinisches Problem dar. Interessanterweise haben Murphy-Roths-Large-Mäuse (MRL) in mehreren Gewebearten, einschließlich Sehnen, eine verbesserte Heilung im Vergleich zu anderen Mausstämmen[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2019)

BackgroundCardiac biomarker release signifying myocardial injury post-transcatheter aortic valve replacement (TAVR) is common, yet its clinical impact within a large TAVR cohort receiving differing types of valve and procedural approaches is unknown.ObjectivesThis study sought to determine the incidence, clinical impact, and factors associated with cardiac biomarker elevation post TAVR.MethodsThis multicenter study included 1,131 consecutive patients undergoing TAVR with balloon-expandable (58%) or self-expandable (42%) valves. Transfemoral and transapical (TA) approaches were selected in 73.1% and 20.3% of patients, respectively. Creatine kinase-myocardial band (CK-MB) measurements were obtained at baseline and at several time points within the initial 72 h post TAVR. Echocardiography was performed at baseline and at 6- to 12-month follow-up.ResultsOverall, 66% of the TAVR population demonstrated some degree of myocardial injury as determined by a rise in CK-MB levels (peak value: 1.6-fold [interquartile range (IQR): 0.9 to 2.8-fold]). A TA approach and major procedural complications were independently associated with higher peak of CK-MB levels (p < 0.01 for all), which translated into impaired systolic left ventricular function at 6 to 12 months post TAVR (p < 0.01). A greater rise in CK-MB levels independently associated with an increased 30-day, late (median of 21 [IQR: 8 to 36] months) overall and cardiovascular mortality (p < 0.001 for all). Any increase in CK-MB levels was associated with poorer clinical outcomes, and there was a stepwise rise in late mortality according to the various degrees of CK-MB increase after TAVR (p < 0.001).ConclusionsSome degree of myocardial injury was detected in two-thirds of patients post TAVR, especially in those undergoing TA-TAVR or presenting with major procedural complications. A greater rise in CK-MB levels associated with greater acute and late mortality, imparting a negative impact on left ventricular function.

Owners and managers of homegardens have extensive knowledge of plants, their uses, and ecosystemic processes. This knowledge might be highly valuable for many purposes. To enhance ethnobotanical research on homegardens and encourage a discussion of proper methodology, this article presents tools and methods used to collect data in the multidisciplinary study of homegardens in Chiapas, Mexico; Eastern Tyrol, Austria; and Kalimantan, Indonesia. The article defines homegardens and gardeners and explains both the sampling process used in these studies and how contact and rapport was established. Also discussed are possible research questions and hypotheses, equipment used in the field, interviewing strategies, vegetation surveys, and data management. Interviews typically elicit information on preferred garden plants, plant management, homegarden management, and the history of gardening in the study area. It is concluded that homegardens present an excellent opportunity to use and experiment with both informal and formal techniques to collect qualitative as well as quantitative data.