8 results on '"Philipp Stein"'
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2. Biologische und ethische Implikationen von 'Rettungsgeschwistern'
- Author
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Philipp Stein and Philipp Stein
- Abstract
Examensarbeit aus dem Jahr 2018 im Fachbereich Didaktik - Ethik, Note: 1,5, Eberhard-Karls-Universität Tübingen, Sprache: Deutsch, Abstract: Diese Arbeit beschäftigt sich mit der Debatte um die Erzeugung von Rettungsgeschwistern. Der Schwerpunkt liegt auf der ethischen Diskussion, jedoch wird durch einen naturwissenschaftlichen Teil eine ausreichende Basis für das Verständnis der sich ergebenden Probleme geschaffen. Dabei geht es um die Embryogenese, die Blutbildung und um die Indikationen, sprich die Erkrankungen, die Anlass geben, Rettungsgeschwister zu erzeugen. Auch das Vorgehen bei Präimplantationsdiagnostik und HLA-Typisierung wird behandelt. Dann wird die Geschichte der Rettungsgeschwister mit Fallbeispielen erläutert sowie ein Überblick über die Fallzahlen bis heute sowie der rechtlichen Situation in verschiedenen Ländern mit einem Fokus auf Deutschland gegeben. Hinsichtlich der ethischen Problematisierung stehen der moralische Status von Embryonen, der Vorwurf der Instrumentalisierung, die physischen und psychischen Folgen bei Rettungsgeschwister, die Gefahr der Entwicklung zum „Designerbaby“ und die Diskriminierung bestimmter Bevölkerungsgruppen im Fokus. Es werden zudem mögliche Alternativen zur Erzeugung von Rettungsgeschwistern gegeben. Die Entstehung eines Kindes ist immer ein besonderes Ereignis. Die Erzeugung eines Kindes, mit dem Ziel einem anderen Kind das Leben zu retten, ist jedoch außergewöhnlich. Eltern, für die die Zeugung eines solchen Kindes in Frage kommt, haben schon ein weiteres Kind, das allerdings sehr krank, nicht selten todkrank ist und nur durch eine Transplantation hämatopoetischer Stammzellen geheilt werden kann. Das neue Geschwisterkind wird durch In-Vitro-Fertilisation (IVF) gezeugt und nach einer Präimplantationsdiagnostik (PID) in die Gebärmutter der Frau übertragen. Auf diese Weise entstandene Kinder werden als Rettungsgeschwister bezeichnet.
- Published
- 2019
3. Massive coagulopathy caused by the bite of a Crotalus basiliscus snake
- Author
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Philipp Stein, Donat R. Spahn, Fabian Hartmann, Salome Meyer, Joan Fuchs, Renato Lenherr, and University of Zurich
- Subjects
biology ,business.industry ,10216 Institute of Anesthesiology ,Zoology ,Geology ,Ocean Engineering ,610 Medicine & health ,biology.organism_classification ,medicine.disease ,Crotalus basiliscus ,10199 Clinic for Clinical Pharmacology and Toxicology ,Coagulopathy ,medicine ,10023 Institute of Intensive Care Medicine ,business ,Water Science and Technology - Published
- 2017
- Full Text
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4. Indications and Risks of Fibrinogen in Surgery and Trauma
- Author
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Philipp Stein, Gabriela H. Spahn, Donat R. Spahn, and University of Zurich
- Subjects
Male ,medicine.medical_specialty ,10216 Institute of Anesthesiology ,medicine.medical_treatment ,2720 Hematology ,610 Medicine & health ,Liver transplantation ,Fibrinogen ,Perioperative Care ,2705 Cardiology and Cardiovascular Medicine ,Low fibrinogen ,medicine ,Humans ,Cardiac Surgical Procedures ,Blood Coagulation ,medicine.diagnostic_test ,business.industry ,Postpartum Hemorrhage ,Hematology ,Perioperative ,Thromboelastography ,Surgery ,Cardiac surgery ,Thromboelastometry ,Coagulation ,Wounds and Injuries ,Female ,Cardiology and Cardiovascular Medicine ,business ,Algorithms ,medicine.drug - Abstract
Fibrinogen has a central role in coagulation. Following trauma and perioperatively, low fibrinogen levels have been found to be risk factors for exaggerated bleeding, transfusion needs, and adverse outcome. Conversely, treatment with exogenous fibrinogen in critically bleeding patients with low fibrinogen levels has been shown to decrease transfusion needs. Because following trauma and in many perioperative situations fibrinogen is the first coagulation "element" to become critically low, it appears reasonable to target fibrinogen in clinical coagulation algorithms aiming at early specific and goal-directed treatment. A low fibrinogen can be a low plasma concentration or a low functional fibrinogen as assessed by point-of-care techniques such as thromboelastography (TEG) or thromboelastometry (ROTEM). This review summarizes the evidence base for perioperative algorithm-based fibrinogen administration, including the exact thresholds for fibrinogen administration used in the different algorithms. Algorithm-based individualized goal-directed use of fibrinogen resulted in highly significant reduction in transfusion needs, adverse outcomes, in certain studies even mortality, and where investigated reduced costs, with high safety levels at the same time. Best evidence exists in cardiac surgery, followed by trauma, postpartum hemorrhage, and liver transplantation. The introduction of these concepts is highly demanding and requires a tremendous educational effort to familiarize all health care workers with the necessary knowledge and the skills of how to run TEG/ROTEM tests. Future research is needed to compare the efficacy, safety, and costs of different algorithms. This, however, should not prevent us from introducing these expedient point-of-care-based algorithms clinically today.
- Published
- 2016
- Full Text
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5. The Economic Stabilisation Fund — An (Interim) Assessment
- Author
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Philipp Steinberg, Holger Lüthen, Lukas Gehring, and Daniel Schulz-Bianco
- Subjects
Economic theory. Demography ,HB1-3840 ,Social history and conditions. Social problems. Social reform ,HN1-995 - Abstract
Abstract The Economic Stabilisation Fund (ESF) is one of several German state aid instruments set up to combat the economic fallout of COVID-19. The ESF offers a range of instruments from equity to hybrid capital, including silent participation and subordinated loans. In exceptional cases, the ESF may also become a direct shareholder. While the ESF stabilised only a relatively small number of companies, it constitutes an important building block in Germany’s overall business support framework. Due to its tailor-made stabilisation measures, companies of economic significance were successfully stabilised during the pandemic.
- Published
- 2022
- Full Text
- View/download PDF
6. Digital Governance — Further Developing Economic Policy Based on Data and Evidence
- Author
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Philipp Steinberg, Nils Börnsen, and Dirk Neumann
- Subjects
Economic theory. Demography ,HB1-3840 ,Social history and conditions. Social problems. Social reform ,HN1-995 - Abstract
Abstract Digitalisation is bringing about far-reaching changes for the economy and society. Against this backdrop, the Federal Ministry for Economic Affairs and Energy published a concept paper for a regulatory action programme to support the digital transformation in December 2020 as part of the Federal Government’s implementation strategy “Shaping Digitalisation”. Its core thesis is that the basic ideas of regulatory policy remain valid in the digital economy. Its principles are still pillars of the social market economy today and can provide clear orientation for economic policy in the future in an increasingly digital economy. One of the paper’s approaches to the implementation of a digital regulatory policy is examined in more detail: the data- and evidence-based further development of economic policy.
- Published
- 2021
- Full Text
- View/download PDF
7. Economic Policy Challenges of Digitisation
- Author
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Philipp Steinberg and Gero Roser
- Subjects
Economic theory. Demography ,HB1-3840 ,Social history and conditions. Social problems. Social reform ,HN1-995 - Abstract
Abstract Digitisation is bringing far-reaching changes for businesses, employees and consumers. It impacts almost all areas of economic activity. The associated changes in the economy and society pose new challenges for economic policy: It must adapt the regulatory framework to enable innovations in new technologies and fields of application, promote Germany’s competitiveness in a digitised world and ensure competition in digital markets. Through experimental clauses, better digital infrastructure and targeted support for companies, it can ensure that innovations can be implemented and brought to market faster. Small and medium sized enterprises benefit particularly from this. Methods of ‘strategic foresight’ can also help to anticipate the future challenges of digitisation at an early stage and find economic policy answers.
- Published
- 2020
- Full Text
- View/download PDF
8. Nietzschesource
- Author
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Philipp Steinkrüger
- Subjects
collected works ,documentation ,enrichment ,entity identification ,facsimile ,german ,literature ,modern ,nietzsche ,philosophy ,History of scholarship and learning. The humanities ,AZ20-999 ,Information resources (General) ,ZA3040-5185 - Abstract
This review addresses the digital edition of Nietzsche’s works, Nietzschesource. The project presents a definite step ahead in the history of editions of the works of the 19th century philosopher and writer and offers the best text available to date. Moreover, it includes a growing archive of digital facsimiles of Nietzsche’s manuscripts and thus allows a wide base of scholars to suggest corrections and emendations of the established text. As a digital edition, however, it is in many respects disappointing, for it fails to make use of the great possibilities modern editorial techniques offer, for instance, the possibility to enrich texts with contextual material such as information on persons and places mentioned in the texts.
- Published
- 2014
- Full Text
- View/download PDF
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