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These European Resuscitation Council Advanced Life Support guidelines are based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations. This section provides guidelines on the prevention of and ALS treatments for both in-hospital cardiac arrest and out-of-hospital cardiac arrest., Competing Interests: InteressenkonfliktJ. Soar declares his role of Co-editor Resuscitation; he declares institutional research funding for the NAP7 project from the Royal College of Anaesthetists. G.D. Perkins reports funding from Elsevier for his role as an editor of the journal Resuscitation. He reports research funding from the National Institute for Health Research in relation to the PARAMEDIC2 trial and the RESPECT project. J.P. Nolan reports funding from Elsevier for his role as Editor in Chief of the journals Resuscitation and Resuscitation Plus. He reports research funding from the National Institute for Health Research in relation to the PARAMEDIC2 trial and the AIRWAYS2 trial. C.D. Deakin declares research grants from RCUK and funding from the National Institute for Health Research in relation to the PARAMEDIC2 trial and the AIRWAYS2 trial. T. Olasveengen declares research grants from Swedish Heart and Lung Foundation, Laerdal Foundation and Lof -Swedish patient insurance and Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement. B.W. Böttiger declared speakers honorarium from Baxalta, ZOLL, FomF, Bard, Stemple, Novartis Pharma, Philips Market DACH, Bioscience Valuation BSV. T. Pellis declares Speakers honorarium from BARD. [Stand 26.5.2020, Originalartikel in Resucitation] P. Carli, K. Couper, T. Djärv, C. Lott, P. Paal and C. Sandroni declare that they have no competing interests., (© European Resuscitation Council (ERC), German Resuscitation Council (GRC), Austrian Resuscitation Council (ARC) 2021, korrigierte Publikation 2021.)

Informed by a series of systematic reviews, scoping reviews and evidence updates from the International Liaison Committee on Resuscitation, the 2021 European Resuscitation Council Guidelines present the most up to date evidence-based guidelines for the practice of resuscitation across Europe. The guidelines cover the epidemiology of cardiac arrest; the role that systems play in saving lives, adult basic life support, adult advanced life support, resuscitation in special circumstances, post resuscitation care, first aid, neonatal life support, paediatric life support, ethics and education., Competing Interests: InteressenkonfliktJ.P. Nolan reports funding from Elsevier for his role as Editor in Chief of the journals Resuscitation and Resuscitation Plus. He reports research funding from the National Institute for Health Research in relation to the PARAMEDIC2 trial and the AIRWAYS2 trial. G.D. Perkins reports funding from Elsevier for his role as an editor of the journal Resuscitation. He reports research funding from the National Institute for Health Research in relation to the PARAMEDIC2 trial and the RESPECT project and from the Resuscitation Council UK and British Heart Foundation for the OHCAO Registry. J.-T. Gräsner declared speakers honorarium from Weinmann, Fresenius, Ratiopharm, Zoll; he is Scientific Advisor for Zoll Temperaturemanagement. T. Olasveengen declares research funding from Laerdal Foundation and Zoll Foundation. R. Greif declares his role as editor of the journal Trends in Anaesthesia and Critical Care, associate editor European Journal of Anaesthesiology. He reports institutional research funding. J. Soar declares his role as an editor of Resuscitation; he declares institutional research funding for the Audit‑7 project. JL reports funding for his contribution to Paramedic‑2 and OHCHAO project. J. Madar declares occasional advice to Laerdal Medical and Braydenon Newborn Resuscitation Equipment. [Stand 17.5.2020, Originalartikel in Resucitation]. F. Semeraro, C. Lott, P. Van de Voorde, D. Zideman, S. Mentzelopoulos, L. Bossaert, K. Monsieurs and H. Svavarsdóttir declare that they have no competing interests., (© European Resuscitation Council (ERC), German Resuscitation Council (GRC), Austrian Resuscitation Council (ARC) 2021.)

These guidelines of the European Resuscitation Council (ERC) Cardiac Arrest under Special Circumstances are based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations. This section provides guidelines on the modifications required for basic and advanced life support for the prevention and treatment of cardiac arrest under special circumstances; in particular, specific causes (hypoxia, trauma, anaphylaxis, sepsis, hypo-/hyperkalaemia and other electrolyte disorders, hypothermia, avalanche, hyperthermia and malignant hyperthermia, pulmonary embolism, coronary thrombosis, cardiac tamponade, tension pneumothorax, toxic agents), specific settings (operating room, cardiac surgery, cardiac catheterization laboratory, dialysis unit, dental clinics, transportation [in-flight, cruise ships], sport, drowning, mass casualty incidents), and specific patient groups (asthma and chronic obstructive pulmonary disease, neurological disease, morbid obesity, pregnancy)., (© European Resuscitation Council (ERC), German Resuscitation Council (GRC), Austrian Resuscitation Council (ARC) 2021.)