677 results on '"NARCOTICS"'
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2. Rechtliche Risiken bei der Verschreibung suchtmittelhältiger Arzneimittel.
- Author
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Birklbauer, Alois
- Subjects
- *
CONTROLLED substances , *NARCOTICS , *DRUG laws , *DRUG prescribing , *PATIENT autonomy , *CRIMINAL procedure , *GENERAL practitioners , *THERAPEUTICS - Abstract
The article "Legal Risks in Prescribing Medications Containing Controlled Substances" discusses the legal risks associated with prescribing medications that contain substances regulated by drug laws. A case is mentioned in which a general practitioner was charged because he had prescribed medications containing controlled substances to patients in an unreasonable manner and quantity. The doctor was found guilty and sentenced to imprisonment. The article also emphasizes the importance of patient autonomy and proper documentation of medical treatments. It is noted that accurate documentation and the correct date of recording are important to avoid incorrect conclusions. [Extracted from the article]
- Published
- 2022
- Full Text
- View/download PDF
3. Die substitutionsgestützte Behandlung von Menschen mit Opiatabhängigkeit – Nachhaltige Hilfe oder Verlängerung der Abhängigkeit? Eine Studie zu Effizienz und Problematik der Opiatsubstitution
- Author
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Damaris Bretzner and Damaris Bretzner
- Subjects
- Drug addiction--Treatment, Narcotics, Drug addiction
- Abstract
In diesem Buch wird zunächst ein Überblick über Geschichte, Hintergründe und Rahmenbedingungen der Substitutionsbehandlung in Deutschland gegeben und darauf eingegangen, inwieweit soziale Probleme opiatabhängiger Personen durch Aufnahme einer Substitutionsbehandlung behoben werden können bzw. fortbestehen. Anhand von Leitfadeninterviews mit Personen, die sich zum Teil in einer Substitutionsbehandlung befinden und zum Teil ihre Substitutionsbehandlung erfolgreich beendet haben, wird geprüft, ob die Behandlung tatsächlich effektive Hilfe für die Betroffenen darstellt oder ob sie auch Risiken – beispielsweise eine Verhinderung des Ausstiegs aus der Opiatabhängigkeit – mit sich bringt. Auch setzt sich die Studie damit auseinander, welche persönlichen Faktoren im Leben der Interviewten für einen Ausstieg aus bzw. für einen Verbleib in der Substitution ausschlaggebend sind. Zudem wird untersucht, wie die Interviewten ihre Situation erleben und als wie effektiv sie die Angebote des Hilfesystems wahrnehmen.
- Published
- 2022
4. Perioperatives Management der postmortalen Organspende : Anästhesie zwischen Ethik und Evidenz.
- Author
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Englbrecht, Jan Sönke, Lanckohr, Christian, Ertmer, Christian, and Zarbock, Alexander
- Abstract
Background: The number of organs donated after brain death in Germany is far lower than the demand. This underlines the importance of providing the brain-dead donor with optimal medical care throughout the donation process to decrease the risk of graft dysfunction. Several international guidelines and national recommendations guide the intensivists in organ-protective intensive care management of the brain-dead donor.Objective: The anesthetist is a key member during organ retrieval procedures and plays a crucial role in physiological donor management; however, evidence-based recommendations for the perioperative anesthetic management, drug treatment strategies and target values are lacking. Anesthesia literature about donor management is scarce and predominantly composed of reviews of practice, with little exploration of the scientific foundations. The aim of this review is to guide the anesthetist in the organ-protective perioperative therapy. The pathophysiological changes in patients who progress to brain death are briefly summarized. The available evidence, guidelines and expert opinions regarding medical treatment strategies and therapeutic goals in organ-protective therapy are reviewed. The ethical and pathophysiological considerations regarding the performance of anesthesia during organ retrieval are discussed.Methods: This review is based on a selective literature search in PubMed for publications regarding organ donation after brain death (keywords: "brain dead donor", "organ procurement", "organ protective therapy", "donor preconditioning", "perioperative donor management", "ethical considerations of brain dead donor"). International guidelines, national recommendations and expert opinions were given special consideration.Results: Overall, the evidence for optimal perioperative organ-protective care of the brain-dead donor is limited. Most elements in the current recommendations and guidelines are based on pathophysiological reasoning, epidemiological observations or extrapolations from general organ-protective management strategies, and not on evidence from randomized controlled trials. National and international recommendations on treatment goals and drug therapy differ considerably in some aspects. The therapy concepts applied are very heterogeneous. Apart from medical challenges, the ethical circumstances are an additional burden for the entire treatment team. Whether anesthesia is reasonable during organ retrieval remains unclear. There is uncertainty about possible organ-protective effects of anesthetic drugs. Furthermore, ethical considerations raise the question of whether the determination of brain death and the use of anesthetic drugs during the procedure of organ retrieval are compatible with each other.Conclusion: Due to the lack of evidence, perioperative treatment should be guided by intensive care therapy strategies. The discussion about using anesthetic drugs during organ retrieval remains controversial. Pathophysiological considerations support the use of volatile anesthetics because of possible organ-protective effects. The use of neuromuscular blocking is justified to control any possible motor response resulting from spinal cord reflexes, whereas there is no evidence for a benefit from using opioids. Apart from that, it seems ethically problematic to anesthetise a brain-dead donor. Consequently, knowledge about the pathophysiological processes caused by brain death and about organ-protective therapy concepts are just as much a basic requirement as the consideration of ethical problems in organ donation after brain death. Only then are the caregivers able to do justice to both the organ recipient and the organ donor, as well as their relatives in this challenging situation. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
5. Rauschdrogen : Marktformen und Wirkungsweisen
- Author
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Thomas Geschwinde and Thomas Geschwinde
- Subjects
- Drugs of abuse, Narcotics, Substance abuse
- Abstract
Die Neuauflage geht neben den'klassischen', meist halbsynthetisch gewonnenen Drogen wie etwa Cocain vertiefend auf vollsynthetische Rauschdrogen ein, die häufig zunächst als research chemicals etwa im Rahmen der Schmerzbehandlung entwickelt worden waren, seit Beginn des 21. Jahrhunderts jedoch in zunehmendem Ausmaß auch in Deutschland auf den illegalen Drogenmarkt drängen. Gleichzeitig wird verstärkt auch auf pflanzliche Stoffe eingegangen, die in Europa bisher weitgehend unbekannt waren, nunmehr jedoch im Zuge des dominierenden polyvalenten Missbrauchs und riskanter Konsummuster weltweit über Online-Shops ohne weiteres verfügbar sind und in unterschiedlichsten Kombinationen mit Vollsynthetica als'Legal High'-Produkte vertrieben werden - ohne dass die Zusammensetzung für den Konsumenten erkennbar und das Gefährdungspotential einschätzbar wäre. Ein weiterer Schwerpunkt der Neuauflage ist das NpSG (Neue-psychoaktive-Stoffe-Gesetz), mit dem der deutsche Gesetzgeber eine Abkehr vom bisherigen System einer enumerativen Aufnahme aller Stoffe in sog. Positivlisten vollzieht. Ebenfalls ist das sog.'Cannabis-Gesetz'bereits eingearbeitet.
- Published
- 2018
6. Welches ist das ideale Induktionsnarkotikum?
- Author
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Dumps, C. and Bolkenius, D.
- Abstract
Copyright of Anaesthesiologie & Intensivmedizin is the property of DGAI e.V. - Deutsche Gesellschaft fur Anasthesiologie und Intensivmedizin e.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
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7. Blutabnahme und klinische Untersuchung alkoholund/oder suchtgiftbeeinträchtigter Verkehrsteilnehmer iSd § 5 StVO 1960.
- Author
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Kloiber, Bernd and Neuper, Oliver
- Subjects
- *
BLOOD collection , *DRUGGED driving , *DRUNK driving , *TRAFFIC regulations , *NARCOTICS - Abstract
§ 5 Straßenverkehrsordnung 1960 (StVO 1960)1 verpflichtet in öffentlichen Krankenanstalten diensthabende Ärzte klinische Untersuchungen bzw Blutabnahmen an alkohol- und/oder suchtgiftbeeinträchtigten Verkehrsteilnehmern zum Zwecke der Feststellung der Beeinträchtigung durch Alkohol oder Drogen korrekt vorzunehmen. Die ggstl Abhandlung soll einen Überblick über die wesentlichen Inhalte und Verpflichtungen dieser äußerst komplexen Materie bieten. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
8. „Visual snow" bei „Hallucinogen Persisting Perception Disorder".
- Author
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Schatten, Hannah, Eter, Nicole, and Mihailovic, Nataša
- Abstract
Copyright of Der Ophthalmologe is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
9. Rauschdrogen : Geschichte, Substanzen, Wirkung
- Author
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Thomas Köhler and Thomas Köhler
- Subjects
- Drug addiction, Drugs of abuse, Narcotics, Substance abuse, Drug abuse
- Abstract
Ist der Konsum von Cannabis strafbar? Wie schädlich ist Ecstasy? Was sind die körperlichen Folgen jahrelangen Heroinkonsums? Was enthielten die'Hexensalben'? Der Band gibt sachkundig und allgemeinverständlich Auskunft über Zusammensetzung und Wirkungsweisen von psychoaktiven Substanzen, die rauschähnliche Zustände erzeugen, etwa Opioiden, Kokain, Amphetaminen, Halluzinogenen, Schnüffelstoffen sowie weiteren Natur- und Designerdrogen.
- Published
- 2015
10. Medizinische Versorgung mit Cannabis – die Rechtslage klärt sich.
- Author
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Tolmein, Oliver
- Abstract
Copyright of Der Schmerz is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
- Full Text
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11. Anordnung zur Untersuchung bei Verdacht auf ärztlichen Betäubungsmittelmissbrauch?
- Subjects
- *
NARCOTICS , *CIVIL service , *MEDICAL personnel , *DRUG prescription laws , *MEDICAL laws - Abstract
The article presents a report on the government order to examine the medical abuse of narcotic drugs in Germany. Topics discussed here include the formal requirements for instructions under civil service law, suitability for practicing the medical profession, and narcotics prescriptions referring to an increased number of regulations.
- Published
- 2019
- Full Text
- View/download PDF
12. 72/w mit linksseitiger Tibiakopffraktur und Wunde am rechten Unterschenkel : Vorbereitung auf die Facharztprüfung: Fall 12.
- Author
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Rieg, A. D.
- Subjects
- *
ANALGESICS , *ANESTHETICS , *ANTICOAGULANTS , *BLOOD coagulation , *SPINAL injections , *LEG injuries , *LOCAL anesthetics , *NARCOTICS , *SPINAL anesthesia , *TIBIA injuries - Published
- 2019
- Full Text
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13. Neurobiologie der Opioidabhängigkeit.
- Author
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Scherbaum, N. and Bonnet, U.
- Subjects
COGNITION disorders ,DRUG addiction ,GENETICS ,MENTAL illness ,NARCOTICS ,NEUROBIOLOGY ,PHARMACOKINETICS ,CONTINUING education units - Abstract
Copyright of Zentralblatt fuer Arbeitsmedizin, Arbeitsschutz und Ergonomie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
- Full Text
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14. Schmerzinhibition durch Opioide – neue Konzepte.
- Author
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Stein, C.
- Subjects
- *
THERAPEUTIC use of narcotics , *CHRONIC pain , *NARCOTICS , *ANALGESICS , *CELL receptors , *CELLULAR signal transduction , *PHARMACODYNAMICS - Abstract
Background: Opioids are the oldest and most potent drugs for the treatment of severe pain but they are burdened by detrimental side effects, such as respiratory depression, addiction potential, sedation, nausea and constipation. Their clinical application is undisputed in the treatment of acute (e.g. perioperative) and cancer pain but their long-term use in chronic pain has met increasing criticism and has contributed to the current "opioid crisis".Objectives: This article reviews the pharmacological principles and new research strategies aiming at novel opioids with reduced side effects. The basic mechanisms underlying pain and opioid analgesia and other effects of opioids are outlined. To illustrate the clinical situation and medical problems, the plasticity of opioid receptors, intracellular signaling pathways, endogenous and exogenous opioid receptor ligands, central and peripheral sites of analgesic and side effects are discussed.Conclusion: The epidemic of opioid misuse has shown that there is a lack of fundamental knowledge about the characteristics and management of chronic pain, that conflicts of interest and validity of models must be more intensively considered in the context of drug development and that novel analgesics with less addictive potential are urgently needed. Currently, the most promising perspectives appear to be augmenting endogenous opioid actions and the selective activation of peripheral opioid receptors. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
15. Infizierte Narrative. Geschlecht, Sexualpathologie und Autofiktion bei Ingeborg Bachmann.
- Author
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Mairhofer, Marlen
- Subjects
GENDER ,NARCOTICS ,DIAGNOSIS ,INJECTIONS ,SYMPTOMS - Abstract
The following article analyses the nexus of sex and gender, pathology and autofiction in Ingeborg Bachmann's prose through Preciado's self-experiment Testo Junkie, one of the most controversial works on gender, sexuality and society of the last decade. In Bachmann's novel Malina metaphors of injection and infection shape the relationships between the three protagonists. The margins between genders, drugs as medicine and drugs as narcotics turn out to be continuously shifting - those dynamics are not restricted to motifs but also affect style. According to Preciado, we live in a pharmapornographic regime in which the ways we shape our bodies and minds are controlled by authorities who restrict the access to mind- and body-altering drugs. The manipulation of one's biocode without diagnosis and state supervision, the creation of a new narrative of the self in a rogue operation is therefore an act of resistance and gender-terrorism. Bachmann's self-observing autobiographical notes, dreams and the imagined speech to the medical faculty (»Rede an die Ärzteschaft«) in Male Oscuro display the consequences of not being able to identify oneself with the illness-narrative created by doctors - in particular when it turns out to be a thinly disguised version of classic female hysteria. By reclaiming her symptoms as an individual expression of artistic value, Bachmann is able to free herself from such harmful prescriptions. [ABSTRACT FROM AUTHOR]
- Published
- 2019
16. Morphine: Boon and bane.
- Author
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LOBITZ, CARMEN
- Subjects
- *
CONSTIPATION , *VOMITING , *NAUSEA , *NARCOTICS , *PAIN , *INTRAVENOUS therapy , *ALKALOIDS , *OPIUM , *DRUG withdrawal symptoms , *FENTANYL , *CRACK cocaine , *MORPHINE , *PARASYMPATHOLYTIC agents , *NALOXONE , *PHARMACY information services , *OPIOID analgesics ,RISK factors - Published
- 2024
17. Cannabis: Entscheidung beim Gastgeber.
- Subjects
CIGARETTES ,SMOKING ,OKTOBERFEST ,BARS (Drinking establishments) ,RESTAURANTS ,NARCOTICS - Abstract
Copyright of Food-Service is the property of dfv Mediengruppe and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
18. Palliativversorgung statt Lebensverkürzung.
- Author
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Schütz, C. and Sitte, T.
- Abstract
Copyright of Rechtsmedizin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
19. Legalisation and Decriminalisation of Narcotic Drugs and Psychotropic Substances
- Author
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Schloenhardt, Andreas, Ege, Gian, Schwarzenegger, Christian, and Stempkowski, Monika
- Subjects
Betäubungsmittel ,Narcotics ,Betäubungsmittelrecht ,BetmG ,narcotics law ,Bundesgesetz über die Betäubungsmittel und die psychotropen Stoffe ,Federal Act on Narcotics and Psychotropic Substances ,UNODC ,Cannabis Legalisierung ,Cannabis Legalisation ,Drogenpolitik ,drug policy ,UN-Drogenkonvention ,UN drug convention ,Medizinische Verwendung von Drogen ,medical use of illicit drugs - Abstract
Debates about decriminalising or even legalising certain narcotic drugs and psychotropic substances have gained much momentum in recent years. On the surface, it appears that more and more jurisdictions are exploring the introduction of measures to permit, albeit in very controlled ways, the use of some narcotic drugs, if only for medical purposes. Others further agree that the so-called ‘war on drugs’ has failed to produce any meaningful success and that new ways to prevent the abuse of narcotic drugs and psychotropic substances need to be explored. Nevertheless, most jurisdictions continue to impose near-complete bans on the production, manufacturing, trade, transport, supply, sale, and possession of illicit drugs. National authorities, along with international organisations, point out that any move to decriminalise narcotic drugs and psychotropic substances is inconsistent with international law. As part of a joint teaching programme on transnational organised crime, students from the Universities of Queensland, Vienna and Zurich researched the topic of illicit drugs in a year-long course. Some of their academic papers are compiled in this volume, addressing topics reaching from international and national legal frameworks to concrete liberalisation efforts in the past and harm minimisation strategies.; Die Debatten über die Entkriminalisierung oder gar Legalisierung bestimmter Suchtstoffe und psychotroper Substanzen haben in den letzten Jahren stark an Dynamik gewonnen. Oberflächlich betrachtet scheinen immer mehr Länder die Einführung von Maßnahmen zu prüfen, die den Konsum einiger Betäubungsmittel - wenn auch in sehr kontrollierter Form - erlauben, und sei es nur für medizinische Zwecke. Andere Experten sind ebenfalls der Meinung, dass der so genannte ""Krieg gegen die Drogen"" keinen nennenswerten Erfolg gebracht hat und dass neue Wege zur Verhinderung des Missbrauchs von Betäubungsmitteln und psychotropen Substanzen erforscht werden müssen. Dennoch gelten in den meisten Ländern nach wie vor nahezu vollständige Verbote für Produktion, Herstellung, Handel, Transport, Lieferung, Verkauf und Besitz illegaler Drogen. Nationale Behörden und internationale Organisationen weisen darauf hin, dass jeder Schritt zur Entkriminalisierung von Betäubungsmitteln und psychotropen Substanzen im Widerspruch zum Völkerrecht steht. Im Rahmen eines gemeinsamen Lehrprogramms zur grenzüberschreitenden organisierten Kriminalität haben sich Studierende der Universitäten Queensland, Wien und Zürich in einem einjährigen Kurs mit dem Thema illegale Drogen beschäftigt. Einige ihrer aktuellen akademischen Arbeiten sind in diesem Band zusammengestellt. Sie behandeln Themen, die von internationalen und nationalen rechtlichen Rahmenbedingungen über konkrete Liberalisierungsbemühungen in der Vergangenheit bis hin zu Schadensminimierungsstrategien reichen. Übersetzt mit www.DeepL.com/Translator (kostenlose Version)
- Published
- 2022
- Full Text
- View/download PDF
20. THE EFFECT OF ILLICIT TRADE IN NARCOTICS ON GLOBAL ECONOMY
- Author
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ALASMARI Khaled
- Subjects
trade ,narcotics ,global ,illicit ,drugs ,development. ,Business ,HF5001-6182 ,Finance ,HG1-9999 - Abstract
Abstract Illicit markets especially those dealing with narcotics constitute grievous issues to the world’s economies, putting to test global safety, economic progress as well as security and many other aspects. Seemingly, illicit narcotics trade in the last decade – that is 2000 to 2011 underwent a significant boom, resulting from a wide spectrum of illegal drugs such as cocaine as well as heroin among many other hard drugs. In today’s global society, several concerns are emerging on the rise of illicit narcotics trade accompanied with organized crime, chiefly as major hindrances to consistent global economic progress. Apparently, some of the effects of illicit narcotics trade are that; this trade gradually turns upside down business rules, opening way for new unruly market players besides reconfiguring influence in global economics as well as politics. Surprisingly, the revenue from illegal drugs in 2011 alone was roughly 10% of the global GDP. Hence, exaggerating local economies’ incomes and triggering ceaseless conflicts among market players, while at the same time reducing legal business activities likewise disintegrating socioeconomic conditions. An empirical research method was adopted for this study, analyzing illicit trade in narcotics on the global arena as from 2000 to 2011 and its resultant effects. The research findings indicate that, illegal drugs trade particularly on the world economy besides growing at a high rate, it endangers the overall welfare of humans likewise the business environment. This is ostensibly because this trade has high chances of engrossing regional economies into illegal drugs business activities, causing them to neglect sustainable ethical businesses. Now, to effectively address negative economic issues related to illegal drugs trade, there is apparent need for integrated efforts from local as well as international authorities. Such efforts are chiefly to control not only the harmful effects resulting from the use of illicit narcotics, but also from the trade itself and to build sustainable economies. The findings of this study are crucial for regulatory authorities in the global economy, for them to adequately comprehend the effects of illicit trade in narcotics hence inform their decisions to take necessary measures. This paper is on the effect of illicit trade in narcotics on global economy, touching on issues like peace along with social cohesion as well as security and economic progress.
- Published
- 2013
21. Juveniles, young people, education, drugs and justice / Menores, jóvenes, educación, drogas y justicia
- Author
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Concepción Nieto Morales
- Subjects
Friends ,consumption ,narcotics ,addictions ,offence ,drugs consumption ,Social Sciences - Abstract
Drug consumption has been normalized for young people nowadays. They start consuming hashish in an early age. Some of them keep that consumption with small amounts or quit, and others increase it and even enlarge the range of substances to consume. Those juveniles accumulating school failure can’t reach the rest of students’ level and can’t pass the academic tests, which results in expulsions, leisure time and relationships with other individuals in the same circumstances: they spend most of the time idle, gathering in groups in the same circumstances of idleness and disruptive conducts. Boredom leads them to start consuming hashish and other narcotic substances, which ends sometimes in very serious addictions, and judicial problems.
- Published
- 2012
- Full Text
- View/download PDF
22. Rauschdrogen : Marktformen und Wirkungsweisen
- Author
-
Thomas Geschwinde and Thomas Geschwinde
- Subjects
- Narcotics, Substance abuse, Drugs of abuse
- Abstract
Die Neuauflage geht neben den'klassischen', meist halbsynthetisch gewonnenen Drogen wie etwa Cocain vertiefend auf vollsynthetische Rauschdrogen ein, die häufig zunächst als research chemicals etwa im Rahmen der Schmerzbehandlung entwickelt worden waren, seit Beginn des 21. Jahrhunderts jedoch in zunehmendem Ausmaß auch in Deutschland auf den illegalen Drogenmarkt drängen. Gleichzeitig wird verstärkt auch auf pflanzliche Stoffe eingegangen, die in Europa bisher weitgehend unbekannt waren, nunmehr jedoch im Zuge des dominierenden polyvalenten Missbrauchs und riskanter Konsummuster weltweit über Online-Shops ohne weiteres verfügbar sind und in unterschiedlichsten Kombinationen mit Vollsynthetica als'Legal High'-Produkte vertrieben werden - ohne dass die Zusammensetzung für den Konsumenten erkennbar und das Gefährdungspotential einschätzbar wäre. Ein weiterer Schwerpunkt der Neuauflage widmet sich'Lifestyle'-Medikamenten, etwa aus der Gruppe der Amfetamin-artigen Stimulantia, die ebenfalls weltweit u.a. im Online-Handel zum'Cognitive Enhancement'angeboten und ohne medizinische Indikation zur kognitiven Leistungssteigerung eingenommen werden.
- Published
- 2007
23. [Opioid agonist therapy and the German Narcotic Drugs Prescription Ordinance from the pharmacist's perspective]
- Author
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Silke, Kuhn, Kirsten, Lehmann, Bernd, Schulte, and Uwe, Verthein
- Subjects
Analgesics, Opioid ,Narcotics ,Pharmaceutical Preparations ,Germany ,Humans ,Pharmacists ,Drug Prescriptions - Abstract
Opioid agonist therapy (OAT) has been established to be the most important therapy option for improving health and social burdens of people with opioid dependence. Pharmacies provide drug substitutes to substitution practices or outpatient clinics and administer drugs to substituted patients (medication under visual control) or supply prescriptions for unsupervised, at-home use by patients. Given the gaps in medical care, the relevance of pharmacies for the comprehensive treatment of opioid-dependent patients will become even more important in the future. The 3Between November 2020 and March 2021, pharmacists in the German federal states of Hamburg, North-Rhine Westphalia, Saxony, and Bavaria were informed by their State Chambers of Pharmacists about participation in this online study. A total of 480 questionnaires were evaluated. The analysis differentiates between pharmacists who are currently involved in the substitution of opioid-dependent patients (54.2%), pharmacists who were involved in the past (21.4%), and those who have never been involved in opioid substitution (24.4%).Pharmacists involved in OAT have not seen any positive changes resulting from the 3The 3
- Published
- 2021
24. Anästhesie und Pädiatrie.
- Author
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Oeding, J. and Seidel, B.
- Abstract
Copyright of Monatsschrift Kinderheilkunde is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2016
- Full Text
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25. [Opioid Substitution Treatment in Germany: Physicians' View on the Effects of the 3rd Revision of the Narcotic Drugs Prescription Ordinance]
- Author
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Kirsten, Lehmann, Silke, Kuhn, Bernd, Schulte, Hans-Günter, Meyer-Thompson, and Uwe, Verthein
- Subjects
Male ,Narcotics ,OST ,Opioidabhängigkeit ,opioid substitution therapy ,Originalarbeit ,Opioidsubstitutionstherapie ,NDPO ,Middle Aged ,Opioid-Related Disorders ,Drug Prescriptions ,Pharmaceutical Preparations ,BtMVV ,opioid dependence ,Germany ,Physicians ,Opiate Substitution Treatment ,Humans ,BtMVVÄndV ,Evaluation - Abstract
Opioid substitution treatment (OST) is the most effective drug treatment for opioid dependence worldwide. This form of therapy is also well established in Germany. Nevertheless, there are gaps in the provision of care, especially in rural areas and some states, due to a decreasing number of physicians involved in implementing the substitution programs. The 3Between August and December 2019, a questionnaire on individual experiences with the changes implemented in 3The response rate of physicians was 34.1%. The average age was 57.9 (±8.7) years, and 64.5% were male. The most relevant changes of the NDPO revision were found to be no time limit for achieving opioid abstinence (85.3%), new assessment and treatment using additional psychotropic substances (71.0%), extending take-home regulation to a maximum of 30 days (70.0%) and greater legal certainty (66.2%). Widening of consultative care up to 10 patients met with little approval (14.8%); 36.7% did not believe that care of substituted patients was assured either now or in the future.The NDPO revisions were considered to be relevant in terms of increased legal certainty and treatment liberties. Information was needed in rural areas, among physicians who carried out substitution therapy without advanced training in addiction medicine and physicians no longer involved in substitution therapy.Die weltweit effektivste Behandlungsform der Opioidabhängigkeit ist die Substitutionsbehandlung mit Opioiden (Opioidsubstitutionstherapie – OST). Diese Therapieform ist auch in Deutschland etabliert. Jedoch bestehen Versorgungslücken, v. a. in ländlichen Gebieten und einzelnen Bundesländern, was auf eine abnehmende Anzahl substituierender ÄrztInnen zurückzuführen ist. Mit der 3. Verordnung zur Änderung der Betäubungsmittel-Verschreibungsverordnung (3. BtMVVÄndV) in 2017 wurden ärztlich-therapeutische Aufgaben der OST in die Richtlinienkompetenz der Bundesärztekammer überführt. Die umfassende Reform der Rahmenbedingungen der OST führt zu einer stärkeren Rechtssicherheit dieser Behandlungsform. Die vorliegende Studie zielt darauf ab, die Auswirkungen der 3. BtMVVÄndV aus der Behandelndenperspektive zu analysieren.Ein Fragebogen zu individuellen Erfahrungen mit den Veränderungen durch die 3. BtMVVÄndV wurde zwischen August und Dezember 2019 an 2503 substituierende ÄrztInnen in Deutschland sowie an 563 nicht oder länger nicht mehr substituierende ÄrztInnen in Hamburg, Bayern, Nordrhein-Westfalen sowie Sachsen verschickt. Die Versendung erfolgte über die Bundesopiumstelle sowie die Kassenärztlichen Vereinigungen der ausgewählten Bundesländer. Die Auswertung differenziert zwischen substituierenden ÄrztInnen mit und ohne suchtmedizinische Weiterbildung sowie zwischen städtischen und ländlichen Kreisen.Die Rücklaufquote substituierender ÄrztInnen lag bei 34,1%. Das Durchschnittsalter betrug 57,9 (± 8,7) Jahre und 64,5% waren männlich. Aus substitutionsärztlicher Sicht waren die relevantesten Änderungen der 3. BtMVVÄndV keine zeitliche Vorgabe für das Erreichen einer Opioidabstinenz (85,3%), die neue Bewertung und Behandlung des Konsums weiterer psychotroper Substanzen (71,0%), die Möglichkeit, die Take-Home-Verordnung auf 30 Tage auszudehnen (70,0%) sowie die größere Rechtssicherheit (66,2%). Die Ausweitung der Konsiliarbehandlung auf 10 PatientInnen erfuhr mit 14,8% wenig Zustimmung. 36,7% sah die Versorgung substituierter PatientInnen weder aktuell noch zukünftig gesichert.Die Neuerungen durch die 3. BtMVVÄndV wurden positiv aufgenommen und hinsichtlich der erhöhten Rechtssicherheit und therapeutischen Freiheiten als relevant eingestuft. Informationsbedarf besteht in ländlichen Gebieten, bei substituierenden ÄrztInnen ohne suchtmedizinische Weiterbildung sowie bei ÄrztInnen, die in der Vergangenheit substituierten, es aktuell jedoch nicht mehr tun.
- Published
- 2021
26. Blühendes Gift.
- Subjects
- *
OPIUM , *DRUG abuse , *CRIME , *NARCOTICS - Abstract
The article reports on a central role played by opium in Afghanistan's economy. It mentions that opium is used to finance various warlords, drug lords, and the Taliban, and generates over half of the country's economic output, in addition, opium trade also has a dark side with crime, exploitation, and addiction impacting the population, especially women and girls. It also mentions that in 2022, opium cultivation was banned, but the enforcement and impact of the ban remain uncertain.
- Published
- 2022
27. Drogenkonsum im Zusammenhang mit einer Großveranstaltung in Mecklenburg-Vorpommern.
- Author
-
Talarico, G., Bockholdt, B., and Below, E.
- Abstract
Copyright of Rechtsmedizin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2014
- Full Text
- View/download PDF
28. [Poisoning by addictive substances, laboratory tests, and forensic medical death clarification in the case of poisoning]
- Author
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Stefanie, Iwersen-Bergmann and Hilke, Andresen-Streichert
- Subjects
Narcotics ,Substance-Related Disorders ,Germany ,Poisoning ,Prevalence ,Humans ,Reproducibility of Results - Abstract
Clinical-toxicological investigations are very helpful for the detection and assessment of the severity of questionable narcotics intoxications. In some cases, an initial case of clinical poisoning then progresses in the further course to a case of forensic relevance (for example after deliberate poisoning e.g, with knock-out drugs or with intend to commit murder, or in cases of intoxication in connection with a criminal offense).The specifics and problems of the analytical detection of these substances in clinical and forensic cases are explained with regard to the presented narcotic drugs. The information used comes from data from our own examination material and data from the literature.The spectrum of addictive substances has changed significantly in recent years. While established methods of detection are available for alcohol and classic drugs of abuse, new drugs with potential for abuse (such as methylphenidate, pregabalin) or NPS, GHB, GBL, and 4‑BD cannot be detected by conventional methods of immunochemistry in combination with chromatographic methods such as GC-MS and HPLC-DAD.An improvement in the measurement equipment for specialised laboratories performing such investigations is therefore required in order to be able to adequately care for patients and to clarify criminal offenses. In the interests of legal certainty, it is important for offenders, in the case of a foreign substance being supplied to a victim, to assume that it can also be proven. In addition, with regard to the reliability of officially stated prevalence data for narcotic drugs in drug-related deaths, greater safety should be sought in the collection of all relevant substances.
- Published
- 2019
29. Trends - geschüttet und gerührt!
- Subjects
LABOR market ,SKILLED labor ,FOOD industry ,FEDERAL government ,NARCOTICS - Abstract
Copyright of Pharma + Food is the property of Hüthig GmbH and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
30. Silexan und Narkose.
- Author
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Decker, S.O. and Polarz, H.
- Subjects
- *
TRANQUILIZING drugs , *ANXIETY disorders , *GABA receptors , *DRUG-herb interactions , *NARCOTICS , *LAVENDER oil , *PROPOFOL - Abstract
The increased use of phytotherapeutic drugs means that anesthetists are more often confronted with these drugs. In this case report possible problems which can occur are demonstrated exemplified by silexan. Silexan is a phytotherapeutic anxiolytic which is used in anxiety disorders. Because of its potential mechanism of action via the neurotransmitter gamma-aminobutyric acid (GABA) receptors interactions with narcotic drugs are possible. The case of an 18-year-old girl who underwent an operation under general anesthesia while taking silexan as long-term medication is presented. The desired depth of narcosis could only be reached by inhalative induction with sevoflurane after unsuccessful induction attempts using intravenous propofol and thiopental. Possible explanations for this route and inhalative induction as a possible alternative are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
31. Die Versorgung des Rettungsdienstes mit Arznei- und Betäubungsmitteln.
- Author
-
Jäkel, C. and Lippert, H.-D.
- Abstract
Copyright of Notfall & Rettungsmedizin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2010
- Full Text
- View/download PDF
32. Umgang mit (nicht mehr) benötigten Betäubungsmitteln in der ambulanten Palliativversorgung.
- Author
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Thöns, M., Flender, H.J., Mertzlufft, F., and Zenz, M.
- Abstract
Copyright of Der Schmerz is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2010
- Full Text
- View/download PDF
33. Entwicklung von ökotoxikologischen Instrumenten und ihre rechtliche Implementierung zur marinen ökologischen Risikobewertung von Chemikalien, Pestiziden und Baggergut.
- Author
-
Floeter, C., Ratte, H. T., and Ahlf, W.
- Abstract
Copyright of Umweltwissenschaften und Schadstoff-Forschung is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2009
- Full Text
- View/download PDF
34. Korrekte Erfassung von Arzneimittelroutinedaten bei Betäubungsmittelrezepten und Muster 16 im Jahr 2006.
- Author
-
Hoffmann, Falk, Glaeske, Gerd, and Pfannkuche, Matthias S.
- Subjects
DRUGS ,NARCOTICS ,MEDICAL prescriptions ,CLAIMS-made policies ,MEDICARE claims administration ,MEDICATION therapy management ,MEDICAL care research ,HEALTH insurance - Abstract
Copyright of GMS Medizinische Informatik, Biometrie und Epidemiologie is the property of German Medical Science Publishing House gGmbH and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2008
35. Umgang mit Medikamenten verstorbener Hospizgäste in Deutschland.
- Author
-
Thöns, M. and Zenz, M.
- Abstract
Copyright of Der Schmerz is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2006
- Full Text
- View/download PDF
36. Analgosedierung mit Remifentanil bei spontan atmenden Patienten für Eingriffe in der interventionellen Radiologie.
- Author
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Moser, B, von Goedecke, A, Chemelli, A, Keller, C, Voelckel, W, Lindner, K H, and Wenzel, V
- Subjects
BILIARY tract ,PAIN ,PREVENTIVE medicine ,ANALGESIA ,ANALGESICS ,CLINICAL trials ,COMPARATIVE studies ,RESEARCH methodology ,MEDICAL cooperation ,NARCOTICS ,PATIENT satisfaction ,PIPERIDINE ,QUESTIONNAIRES ,RESEARCH ,SURGICAL stents ,EVALUATION research ,PAIN measurement ,VISUAL analog scale ,MEDICAL drainage ,PHYSIOLOGY - Abstract
Introduction: Percutaneous transhepatic biliary drainage (PTBD) and stenting are very painful procedures in interventional radiology and require potent analgesia; employing remifentanil in spontaneously breathing patients may be one possible strategy.Patients and Methods: The study group was composed of 18 men and 2 women with a mean age of 63+/-10 (mean+/-SD) years. Pain intensity was measured with a VAS score before the procedure, after local anesthesia on the rib cage, after stenting and after the radiology procedure.Results: Remifentanil infusion (dosage: 0.12-0.30 microg/kg body weight/min) was infused throughout the entire radiology procedure according to physical status, past medical history, individual pain, and clinical assessment. During insufflation of 10l O(2)/min via a venturi mask, oxygen saturation did not fall below 96% at any time-point during the procedure. In the VAS score, we noted a decrease after starting the remifentanil infusion towards the end of procedure. All patients were able to move into bed without help. Postoperatively, no analgesics and no antiemetics were needed.Conclusions: Employing a remifentanil infusion for brief interventional radiology procedures in palliative treatment of patients resulted in high patient and radiologist comfort. [ABSTRACT FROM AUTHOR]- Published
- 2005
37. Pharmakologische Besonderheiten und Probleme des älteren Patienten.
- Author
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Kratz, C D, Schleppers, A, Iber, T, and Geldner, G
- Subjects
ANALGESICS ,ANESTHESIA ,ANESTHETICS ,CONDUCTION anesthesia ,MUSCLE relaxants ,NARCOTICS ,QUESTIONNAIRES ,IMPACT of Event Scale - Abstract
Because of demographic developments, the fraction of the German population over 65 years of age in the year 2025 will have risen to 20% and will continue to rise so that in 2030 this number will have doubled compared to today's numbers. This has a huge impact on the requirements for anaesthesiologic procedures. In addition to the frequent multi-morbidity in this age group, physiologic changes also occur in the elderly which have to be taken into consideration during the entire perioperative management of these patients. Renal, cardiovascular and hepatic function are impaired in many elderly patients. A major concern in addition to cardiovascular and operative complications is the postoperative cognitive dysfunction (POCD), not only because of its implications for the patient but also because of economical consequences. Regional anaesthesia has some benefits when compared to general anaesthesia as it leads to a reduction in thromboembolic and respiratory complications. [ABSTRACT FROM AUTHOR]
- Published
- 2005
38. Eine faktorielle Studie von 6 Interventionen zur Vermeidung von Ubelkeit und Erbrechen nach Narkosen Ergebnisse des "International Multicenter Protocol to assess the single and combined benefits of antiemetic strategies in a controlled clinical trial of a 2x2x2x2x2x2 factorial design" (IMPACT).
- Author
-
Apfel, C C, Bacher, A, Biedler, A, Danner, K, Danzeisen, O, Eberhart, L H J, Forst, H, Fritz, G, Hergert, M, Frings, G, Goebel, A, Hopf, H-B, Kerger, H, Kranke, P, Lange, M, Mertzlufft, F, Motsch, J, Paura, A, Roewer, N, and Schneider, E
- Subjects
ONDANSETRON ,DROPERIDOL (Drug) ,DEXAMETHASONE ,ANALGESICS ,ANTIEMETICS ,COMBINATION drug therapy ,COMPARATIVE studies ,EXPERIMENTAL design ,FENTANYL ,INTRAVENOUS anesthetics ,RESEARCH methodology ,MEDICAL cooperation ,MEDICAL protocols ,NARCOTICS ,PIPERIDINE ,RESEARCH ,EVALUATION research ,RANDOMIZED controlled trials ,RELATIVE medical risk ,PROPOFOL ,ODDS ratio ,INHALATION anesthetics ,THERAPEUTICS - Abstract
Background: Untreated, one third of patients who undergo surgery will have postoperative nausea and vomiting. Although many trials have been conducted, the relative benefits of prophylactic antiemetic interventions given alone or in combination remain unknown.Methods: In a randomized, controlled trial of factorial design, 5,199 patients at high risk for postoperative nausea and vomiting were randomly assigned to 1 of 64 possible combinations of 6 prophylactic interventions: 1) 4 mg of ondansetron or no ondansetron; 2) 4 mg of dexamethasone or no dexamethasone; 3) 1.25 mg of droperidol or no droperidol; 4) propofol or a volatile anesthetic; 5) nitrogen or nitrous oxide; 6) remifentanil or fentanyl. The primary aim parameter was nausea and vomiting within 24 h after surgery, which was evaluated blindly.Results: Ondansetron, dexamethasone, and droperidol each reduced the risk of postoperative nausea and vomiting by about 26%, propofol reduced the risk by 19%, and nitrogen by 12%. The risk reduction with both of these agents (i.e., total intravenous anesthesia) was thus similar to that observed with each of the antiemetics alone. All the interventions acted independently of each other and independently of the patients' baseline risk. Consequently, the relative risks associated with the combined interventions could be estimated by multiplying the relative risks associated with each intervention. However, absolute risk reduction was a critical function of patients' baseline risk.Conclusions: Because antiemetic interventions are similarly effective and act independently, the safest or least expensive should be used first. Prophylaxis is rarely warranted in low-risk patients, moderate-risk patients may benefit from a single intervention, and multiple interventions should be reserved for high-risk patients. [ABSTRACT FROM AUTHOR]- Published
- 2005
39. Präklinisches Management der akzidentellen Methadonintoxikation bei einem 4-jährigen Mädchen. Antagonisierung oder Intubation?
- Author
-
Hainer, C, Bernhard, M, and Gries, A
- Subjects
ANALGESICS ,COMA ,EMERGENCY medical services ,METHADONE hydrochloride ,NALOXONE ,NARCOTIC antagonists ,NARCOTICS ,OXYGEN therapy ,RESPIRATORY insufficiency ,TRACHEA intubation ,THERAPEUTICS - Abstract
We report on the preclinical management of a 4-year-old child who was found in a comatose condition with respiratory failure after accidental ingestion of methadone. Emergency airway management was carried out with endotracheal intubation instead of administering the antagonist naloxone. The child could be extubated 12 h later and was released from hospital after 3 days with no neurological symptoms. The authors attempt to formulate an algorithm for the preclinical management of opioid intoxication with reference to the literature and own experience. Endotracheal intubation seems to be superior to the use of the antagonist naloxone, especially in a critical situation. This is the only way to ensure a rapid oxygenation with adequate airway protection and with the simultaneous avoidance of the side-effects of naloxone. A restrictive and critical administration of the opioid antagonist naloxone is recommended when there is suspicion of opioid ingestion but no signs of intoxication. [ABSTRACT FROM AUTHOR]
- Published
- 2004
40. [Foil Smoking/Heroin Inhalation]
- Author
-
Ayla, Yalamanoglu and Macé M, Schuurmans
- Subjects
Heroin ,Narcotics ,Administration, Inhalation ,Smoking ,Humans - Abstract
Foil Smoking/Heroin Inhalation
- Published
- 2019
41. Tsambikakis/Rostalski (Hrsg.), Medizinstrafrecht.
- Author
-
Ratzel, Rudolf
- Subjects
- *
MEDICAL laws , *CRIMINAL law , *DRUG laws , *TEXTBOOKS , *PHARMACY laws , *RESEARCH personnel , *NARCOTICS , *NONFICTION - Abstract
The present text is a book review of the commentary "Tsambikakis/Rostalski (eds.), Medizinstrafrecht" (Medical Criminal Law). The commentary deals with various laws and regulations in the field of medical criminal law, including the Medicines Act, the Narcotics Act, and the Transplantation Act. The author team consists of practitioners, teachers, and researchers, and offers a differentiated and up-to-date presentation of medical law. The commentary also takes a position on various interpretations and is a recommended source for medical criminal law issues. [Extracted from the article]
- Published
- 2023
- Full Text
- View/download PDF
42. Umsatzsteuerliche Behandlung von Dienstleistungen durch Apotheken; Grippeschutzimpfungen und Sichtvergaben von Substitutionsmitteln.
- Subjects
FEDERAL courts ,VALUE-added tax ,DRUGSTORES ,INFLUENZA vaccines ,NARCOTICS - Abstract
The article presents ruling of Germany's Federal Fiscal Court on the value-added tax (VAT) treatment of services through pharmacies, flu vaccinations and visas of substitution drugs. It mentions about the narcotics prescription ordinance substitution drugs to the patient for immediate leave consumption; and there will be no complaints if the entrepreneur is his services.
- Published
- 2021
- Full Text
- View/download PDF
43. Die Anwendung farbmetrischer Meßmethoden zur optischen Beurteilung von weißlichen Pulver-Proben.
- Author
-
Bohnert, M. and Werp, J.
- Abstract
Copyright of Rechtsmedizin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 1999
- Full Text
- View/download PDF
44. Infusionsanalgesie mit Remifentanil.Ein neues Verfahren zur Schmerzausschaltung bei der transvaginalen Follikelpunktion vor In-vitro-Fertilisation.
- Author
-
Wilhelm, W, Biedler, A, Hammadeh, M E, Fleser, R, and Grüness, V
- Subjects
THERAPEUTIC use of narcotics ,ANALGESICS ,CLINICAL trials ,COMPARATIVE studies ,FERTILIZATION in vitro ,INTRAVENOUS therapy ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,NARCOTICS ,PAIN ,PIPERIDINE ,RESEARCH ,PULMONARY function tests ,EVALUATION research ,OVUM donation ,THERAPEUTICS - Abstract
Introduction: Transvaginal puncture for oocyte retrieval is a short-lasting but painful procedure. We hypothesized that a sole infusion of the ultra-short acting mu-agonist remifentanil may be a suitable and well-controllable single-agent analgesic technique that can dose-dependently be applied to spontaneously breathing patients.Methods: Fifty consenting adult women were enrolled in this prospective trial. A sedative premedication was omitted, all patients received 3 L/min of inhaled oxygen, and a sole remifentanil infusion was started with 0.25 microg/kg/min. Remifentanil was adjusted as needed for pain relief (in steps of 0.05 microg/kg/min) and finished after the last puncture. Dosage requirements, vital functions, oxygen saturation (as achieved by pulse oximetry, psO(2)), adverse drug effects and the level of sedation (LOS 1-5; 1 = asleep/unarousable, 4 = calm/awake) were recorded. Remifentanil plasma concentrations were achieved by STANPUMP pharmacokinetic simulation. Data are presented as mean +/- SD.Results: A total of 50 women (31.8 +/- 5.1 yr, 67.3 +/- 14. ASA I or II ) were investigated. Follicular aspiration lasted 10.8+/-5.2 min, and remifentanil was infused for 19.7+/-8.3 min. Dosage requirements were 0.25 microg/kg/min in 70% of all patients, 0.3 microg/kg/min in 22%, 0.2 microg/kg/min in 6%, and 0.4 microg/kg/min in 2% of all cases. Vital signs (baseline, after 1(st) puncture, end of surgery) nearly remained unchanged: heart frequency = 85 +/- 15, 87 +/- 17, 90 +/- 17 bpm, systolic blood pressure = 129 +/- 12, 132 +/- 13, 131 +/- 14 mmHg; respiratory rate = 116 +/- 4, 15 +/- 4 breaths/min; psO(2) = 99 +/- 1, 99 +/- 1, 99 +/- 2%. LOS was 4.0 (all), 3.9 +/- 0.3, 3.9 +/- 0.3. Remifentanil plasma concentrations were 5.0 +/- 1.3 ng/mL at the start, 6.6 +/- 1.3 at the end of surgery and 1.2 +/- 0.5 at PACU arrival. Adverse drug effects: 54% itching, no muscle rigidity. 94% of all women would choose this technique again.Conclusions: The sole infusion of remifentanil is a suitable and satisfying single-agent monitored anaesthesia care technique for oocyte retrieval. However, close anaesthetic observation - especially of the respiratory function - is mandatory. [ABSTRACT FROM AUTHOR]- Published
- 1999
45. The transporter-mediated cellular uptake of pharmaceutical drugs is based on their metabolite-likeness and not on their bulk biophysical properties: Towards a systems pharmacology
- Author
-
Douglas B. Kell
- Subjects
Narcotics ,Systems biology ,Metabolite ,Biophysics ,Metabolic network ,Computational biology ,Biology ,Pharmacology ,Recon2 ,Permeability ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Drug transporters ,lcsh:Science ,lcsh:Science (General) ,030304 developmental biology ,0303 health sciences ,General anaesthetics ,Systems pharmacology ,Intermediary Metabolism ,Biological membrane ,Transporter ,chemistry ,030220 oncology & carcinogenesis ,Lipophilicity ,lcsh:Q ,lcsh:Q1-390 - Abstract
SummarySeveral recent developments are brought together: (i) the new availability of a consensus, curated human metabolic network reconstruction (Recon2), approximately a third of whose steps are represented by transporters, (ii) the recognition that most successful (marketed) drugs, as well as natural products, bear significant similarities to the metabolites in Recon2, (iii) the recognition that to get into and out of cells such drugs hitchhike on the transporters that are part of normal intermediary metabolism, and the consequent recognition that for intact biomembrane Phospholipid Bilayer diffusion Is Negligible (PBIN), and (iv) the consequent recognition that we need to exploit this and to use more phenotypic assays to understand how drugs affect cells and organisms. I show in particular that lipophilicity is a very poor predictor of drug permeability, and that we need to (and can) bring together our knowledge of both pharmacology and systems biology modelling into a new systems pharmacology.
- Published
- 2015
46. Anästhesie und Pädiatrie: Über Grenzen hinweg voneinander lernen
- Author
-
Oeding, J. and Seidel, B.
- Published
- 2016
- Full Text
- View/download PDF
47. Medikamente gegen Geburtsschmerzen.
- Author
-
Jage, J
- Subjects
THERAPEUTIC use of narcotics ,ANALGESICS ,COMPARATIVE studies ,RESEARCH methodology ,MEDICAL cooperation ,NARCOTICS ,RESEARCH ,EVALUATION research ,PAIN measurement ,NONOPIOID analgesics ,OBSTETRICAL analgesia ,THERAPEUTICS - Published
- 1995
48. Participatory research in psychology - A practical example in the field of drug counseling
- Author
-
Christoph Vandreier
- Subjects
Critical Psychology ,participatory research ,action research ,narcotics ,addiction ,self-help organization ,Psychology ,BF1-990 - Abstract
This article gives insights into the work of the self-help- and research-group of the "Projekt Selbstverständigung über Drogengebrauch" as an example of participatory research in psychology. In a first step the basics of the project will be discussed by distinguishing it from other approaches in drug research, positioning it within the field of participatory research and analyzing it in regard to its theoretical basics. In a second step the practical work of the project will be described to illustrate problems that emerged as well as first solutions that could be helpful for further development of participatory research.
- Published
- 2011
49. Hirntoddiagnostik nach Gabe von Propofol oder Sufentanil: Empfehlungen zum Umgang mit toxikologischer Analytik
- Author
-
Walter, U., Brüderlein, U., Gloger, M., Mann, S., and Walther, U.
- Published
- 2015
- Full Text
- View/download PDF
50. [Substance abuse detection in substitution therapy : Oral fluid versus urine screening]
- Author
-
Johannes, Stein and Max, Geraedts
- Subjects
Adult ,Male ,Narcotics ,Psychotropic Drugs ,Illicit Drugs ,Middle Aged ,Urinalysis ,Substance Abuse Detection ,Young Adult ,Predictive Value of Tests ,Germany ,Feasibility Studies ,Humans ,Female ,Saliva - Abstract
A patient's health in an opioid maintenance program is potentially endangered due to concurrent consumption of drugs. Therefore, the German Medical Association requests evidence of compliant substitute intake while type and frequency of drug screening is chosen by the physician. This study comparatively assessed the feasibility and potential advantage of oral fluid drug testing versus urine screening in day-to-day practice.Urine and oral fluid-samples of a randomly chosen third of a total of 361 patients, treated in four different practices in a major German city, were tested. The detection rates were compared bivariate and the illicit substance intake of subgroups were analysed. Additionally, patients' and employees' satisfaction with the test procedures were assessed.A total of 117 paired urine and oral fluid samples were considered for this study. A dual sample collection was not obtainable with 29 patients due to insufficient sample volume or refusal. Other than methadone or buprenorphine, 155 substances were found in urine samples, whereas only 82 other substances were detected in oral fluids. Significant differences existed within substance groups with THC being positive in 50 (42.7%) urine samples and only three (2.6%) positive oral fluid samples (p 0.0001) and with benzodiazepines with 41 (35%) positive urine and 28 (23.9%) positive oral fluid samples (p 0.0001), respectively. In total 75.2% of the urine samples were positive for concurrent drug consumption. Employees and patients did not prefer one test type over the other.The confirmation of concurrent drug intake in maintenance setting is generally possible by the use of oral fluid, but inferior to urine screening.
- Published
- 2017
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