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Your search keyword '"Mucin-2"' showing total 2 results
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2 results on '"Mucin-2"'

1. [Increased methylation of promotor region suppresses expression of MUC2 gene in colon carcinoma cells]

Author

Riede E, Alexei Gratchev, Hd, Foss, Mann B, Hj, Buhr, and Hanski C

Subjects
Mucin-2, Colon, Liver Neoplasms, Mucins, DNA Methylation, Prognosis, Gene Expression Regulation, Neoplastic, Cell Transformation, Neoplastic, Lymphatic Metastasis, Colonic Neoplasms, Tumor Cells, Cultured, Humans, Lymph Nodes, RNA, Messenger, Promoter Regions, Genetic
Abstract

MUC2 is known to be the main intestinal mucin carrying the carbohydrate moiety sialyl-Le(x), which interacts with the endothelial molecule E-selectin. This interaction may contribute to the extravasation of tumor cells and thus to the metastatic process. We analysed MUC2 expression in normal colonic, carcinomatous and metastatic tissue and the regulation of MUC2 gene expression. In metastases MUC2 expression was significantly lower than in normal tissue and primary tumors and seems not to be related to the metastatic process. In several colorectal carcinoma cell lines the methylation of the 5'-flanking region of MUC2 correlated with the suppression of the MUC2 gene. The increase of the MUC2 expression after the inhibition of the methylation with 5-aza-2' deoxycytidine strongly support the notion that the suppression of MUC2 gene is causally related to the methylation of the promoter.

Published
2003

2. [Increased methylation of promotor region suppresses expression of MUC2 gene in colon carcinoma cells].

Author

Riede E, Gratchev A, Foss HD, Mann B, Buhr HJ, and Hanski C

Subjects
Cell Transformation, Neoplastic genetics, Cell Transformation, Neoplastic pathology, Colon pathology, Colonic Neoplasms pathology, Gene Expression Regulation, Neoplastic physiology, Humans, Liver Neoplasms genetics, Liver Neoplasms pathology, Lymph Nodes pathology, Lymphatic Metastasis genetics, Lymphatic Metastasis pathology, Mucin-2, Prognosis, RNA, Messenger genetics, Colonic Neoplasms genetics, DNA Methylation, Liver Neoplasms secondary, Mucins genetics, Promoter Regions, Genetic genetics, Tumor Cells, Cultured pathology
Abstract

MUC2 is known to be the main intestinal mucin carrying the carbohydrate moiety sialyl-Le(x), which interacts with the endothelial molecule E-selectin. This interaction may contribute to the extravasation of tumor cells and thus to the metastatic process. We analysed MUC2 expression in normal colonic, carcinomatous and metastatic tissue and the regulation of MUC2 gene expression. In metastases MUC2 expression was significantly lower than in normal tissue and primary tumors and seems not to be related to the metastatic process. In several colorectal carcinoma cell lines the methylation of the 5'-flanking region of MUC2 correlated with the suppression of the MUC2 gene. The increase of the MUC2 expression after the inhibition of the methylation with 5-aza-2' deoxycytidine strongly support the notion that the suppression of MUC2 gene is causally related to the methylation of the promoter.

Published
1998

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