1. An antibody attack against body wasting in cancer
- Author
-
Stephan Herzig and Maria Rohm
- Subjects
0301 basic medicine ,Cachexia ,Growth Differentiation Factor 15 ,Physiology ,Adipose tissue ,Pathogenesis ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Neoplasms ,Medicine ,Animals ,Humans ,Molecular Biology ,Wasting ,biology ,business.industry ,Cancer ,Cell Biology ,medicine.disease ,030104 developmental biology ,Adipose Tissue ,Immunology ,Molecular mechanism ,biology.protein ,GDF15 ,Antibody ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Cachexia is a devastating, non-curable condition in many cancer patients that is marked by severe wasting of the muscle and fat tissue. Its prevention has been hampered by an insufficient knowledge of the underlying molecular mechanism(s) that lead to its pathogenesis. Suriben et al. (2020) now report the development and characterization of an antagonistic antibody for the previously identified GDF15-GFRAL axis that efficiently blocks tumor-induced body wasting in experimental animals. Cachexia is a devastating, non-curable condition in many cancer patients that is marked by severe wasting of the muscle and fat tissue. Its prevention has been hampered by an insufficient knowledge of the underlying molecular mechanism(s) that lead to its pathogenesis. Suriben et al. (2020) now report the development and characterization of an antagonistic antibody for the previously identified GDF15-GFRAL axis that efficiently blocks tumor-induced body wasting in experimental animals.
- Published
- 2020