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Zielsetzung: Aufgrund der notwendigen Injektionshäufigkeit stellt die intravitreale VEGF-Inhibitor-Therapie des diabetischen Makulaödem (DMÖ) eine große Belastung für die Patient:innen dar. 1-Jahres-Resultate der 100-wöchigen Phase-3-Studien YOSEMITE und RHINE unterstützen [zum vollständigen Text gelangen Sie über die oben angegebene URL]

RET.Con 2020: Tagungsband : 3. Regenerative Energietechnik-Konferenz in Nordhausen 13.-14. Februar 2020, p. 229

In der aktuellen Debatte über den Zusammenhang von Kapitalismus und funktionaler Differenzierung, die anlässlich des Grundrisses einer integrativen Theorie der modernen Gesellschaft von Uwe Schimank auch in dieser Zeitschrift geführt wurde, wird ersterer häufig als ›Dominanz der Wirtschaft‹ über andere Teilsysteme konzipiert. Im Beitrag werden zunächst die Schwierigkeiten eines solchen Kapitalismusverständnisses aufgezeigt. Anschließend wird argumentiert, dass ein adäquater Begriff von Kapitalismus weiterhin an ein Verständnis der gesellschaftlichen Produktion gebunden ist. Diese wird in Schimanks Grundriss mit dem Begriff der »Leistungsproduktion« zwar angesprochen, bleibt theoretisch jedoch unterbelichtet. Ein Rückgriff auf Marx‹ Kritik der politischen Ökonomie kann hier weiterhelfen, wobei insbesondere die Unterscheidung von Form und Inhalt gesellschaftlicher Reichtumsproduktion instruktiv ist. Auf ihrer Grundlage lassen sich zwei Dimensionen gesellschaftlicher Differenzierung auseinanderhalten: Die »Leistungsproduktion« der modernen, kapitalistischen Gesellschaft ist zum einen in der Form-Dimension differenziert, und zwar in die vier Sektoren von Ökonomie, Staat, Zivilgesellschaft und Haushalt. Zum anderen ist sie in der Inhalts- bzw. Gebrauchswert- Dimension in verschiedene Produktionsfelder differenziert (etwa: Gesundheit, Bildung, Kunst), die mit verschiedenen und sich wandelnden Schwerpunkten durch die vier Sektoren hindurch institutionalisiert sind. So lässt sich eine von Marx inspirierte Differenzierungstheorie entwickeln, die Schimanks (aber etwa auch Bourdieus) kulturtheoretische Einsichten in die Eigenlogiken der gebrauchswert-geleiteten Produktionsfelder in sich integriert, gleichzeitig aber deren kapitalistische Prägung nicht aus dem Blick verliert., Zeitschrift für Theoretische Soziologie, Bd. 7 Nr. 2 (2018): Natur und Kultur

The hardy spores of Bacillus species are well known for their resistance to unfavorable conditions such as UV and gamma radiation, hydrogen peroxide desiccation, chemical disinfection, or starvation. In particular, Bacillus pumilus strain SAFR-032 that was originally recovered from the Jet Propulsion Lab Spacecraft Assembly Facility has shown to exhibit unusually high resistance to UV radiation and peroxide treatment compared to other Bacillus species. To further understand the resistance of bacterial endospores to relevant outer space environments, spores of B. pumilus SAFR-032 were exposed for 1.5 years to selected parameters of space on board of the International Space Station (ISS). Here we are using a quantitative proteomics approach to gain insights into the resistance mechanism of B. pumilus.

The design of cancer-targeting particles with precisely tuned physicochemical properties may enhance the delivery of therapeutics and access to pharmacological targets. However, a molecular-level understanding of the interactions driving the fate of nanomedicine in biological systems remains elusive. Here, we show that ultrasmall (

Investigations were carried out to assess the efficiency of pulse beetle egg removal device in the removal of eggs of Tribolium castaneum and Rhyzopertha dominica from infested sorghum, wheat, maize and paddy grains and the eggs of Lasioderma serricorne from infested coriander. The efficiency of the device or the impact of rotation was assessed based on the number of offspring adults emerged and percentage reduction in adult emergence compared to untreated controls. Rotation of the grains for three consecutive days for 15 min/day gave the highest reduction in the emergence of offspring adults. Reductions in emergence of T. castaneum and R. dominica were found to be 54 and 57% in sorghum; 69 and 69% in wheat; and 71 and 76% in maize, respectively. There was a 77% reduction in L. serricorne on coriander seed, and a similar level for R. dominica on paddy.

The primary object of the TanDEM-X mission is to generate a highly accurate digital elevation model (DEM) with never achieved accuracy on global scale [1]. But in addition to this DEM acquisition realized by a helix constellation of two satellites, nominal TerraSAR-X operation shall be available anymore, i.e. the bistatic TanDEM-X mission and the monostatic TerraSAR-X mission have to be operated in parallel with both satellites. Consequently the second satellite TDX, successfully launched in June 2010, has to achieve the same accuracy and performance as those of the first satellite TSX, already in-flight since 2007. For this purpose, the commissioning phase (CP) of the TanDEM-X mission was separated into two phases, at first the monostatic phase in order to calibrate the TDX satellite with the same accuracy as achieved for TSX and then the interferometric phase in order to match both satellites for a bistatic constellation and consequently to ensure DEM acquisition during the whole lifetime of the TanDEM-X mission. The main part of all calibration activities, especially of measurements executed against precise reference targets, was concentrated on the monostatic CP for deriving all calibration parameters. The activities executed during the interferometric CP were concentrated on the verification of all these parameters, i.e. whether they are still valid in bistatic constellation and enable consequently a precise synchronization of both systems. Nevertheless, the calibration effort and consequently the duration for commissioning the whole TanDEM-X system could be optimized by the experience and the results which had been achieved for TSX since launch in 2007 [2]. This was the baseline for executing the TanDEM-X commissioning phase as fast as possible. Thus, a maximum overlap of the lifetime of both satellites required for the global DEM acquisition could be achieved. The absolute geometric offset between the TDX and TSX SAR system is smaller than half the wavelength. The radiometric offset is only in the order of one tenth of a dB. Thus, each SAR system could not only be accurately calibrated individually, but also to each other. TDX and TSX are adjusted and calibrated with the accuracy of laboratory equipment. All requirements and/or goals have been achieved improving the predictions in most cases. The measurements and the analyses performed during the interferometric CP were focused on bistatic operation, i.e. one satellite is operated as transmitter and receiver and the other satellite only as a receiver. For this purpose, a bistatic replica, the bistatic geometry, the bistatic elevation patterns and the radiometric characteristics for both bistatic and monostatic operation in close formation were investigated. Based on a short overview of different calibration procedures the paper discusses the calibration results achieved for both monostatic and bistatitc constellation of the whole TanDEM-X system, successfully inflight since June 2010. References [1] G. Krieger, A. Moreira, H. Fiedler, I. Hajnsek, M. Werner, M. Younis, and M. Zink, “TanDEM-X: A Satellite Formation for High Resolution SAR Interferometry,” IEEE Trans. on Geoscience and Remote Sensing, vol. 45, no. 11, pp. 3317-3341, Nov. 2007. [2] M. Schwerdt, B. Bräutigam, M. Bachmann, B. Döring, D. Schrank, and J. H. Gonzalez, “Final TerraSAR-X Calibration Results Based on Novel Efficient Calibration Methods,” IEEE Transaction on Geoscience and Remote Sensing ,Vol. 48, No. 2, February 2010.

The transcription factor C/EBPa regulates early steps of normal granulocyte differentiation since mice with a disruption of the C/EBPa gene do not express detectable levels of the G-CSF receptor and produce no neutrophils. We have recently shown that C/EBPa function is also impaired in acute myeloid leukemias. However, how the transcriptional activity of C/EBPa is regulated both in myelopoiesis and leukemogenesis, is not fully understood. The current study demonstrates that activated Ras enhances the ability of C/EBPa to transactivate the G-CSF receptor promoter and a minimal promoter containing only C/EBP DNA binding sites. Ras signaling activates C/EBPa via the transactivation domain, because it enhances the transactivation function of a fusion protein containing a Gal4 DNA binding domain and the C/EBPa transactivation domain, and does not change C/EBPa DNA binding. Ras acts on serine 248 of the C/EBPa transactivation domain, as it does not enhance the transactivation function of a C/EBPa serine 248 to alanine point mutant. Interestingly, serine 248 of C/EBPa is a PKC consensus site, and a PKC inhibitor blocks the activation of C/EBPa by Ras. Ras signaling phosphorylates C/EBPa on serine 248 in vivo. Finally, mutation of serine 248 to alanine obviates the ability of C/EBPa to induce granulocytic differentiation. These data suggest a model where Ras signaling enhances the activity of C/EBPa to induce granulocytic differentiation by phosphorylation of serine 248.

Die Verbindungen [(C6H5)4P]2[Mo(NO)(H2NO)(NCS)4] 1, [(C6H5)4P]2-[Mo(NO)((C2H5)2CNO)(NCS)4]2, [(C6H5)4P]2[Mo(NO)2(NCS)4] · CH3OH 3, [(C6H5)4P]3[Mo(NO)(CN)5] · 2H2O 4, Cs2[Mo(NO)Cl4(H2O)] 5 und Cs2[Mo(NO)Cl5] 6 wurden dargestellt und durch vollstandige Rontgen-Struktur-Analyse charakterisiert. Alle komplexen Anionen besitzen etwa lineare MoNO-Gruppen, wobei in 1 und 2 eine pentagonalbipyramidale und in 3–6 eine oktaedrische Koordination des Molybdans vorliegt. Komplexe mit {MoNO}n (n = 4, 5, 6)-Konfiguration lassen sich durch bemerkenswerte Redox-Reaktionen ineinander uberfuhren. Einige neuartige Reaktionen des Hydroxyl-amido(−1)-Liganden (Bildung von 2 und 3) werden kurz diskutiert. Preparation, Redox Properties, and Structures of Mononuclear „Simple” Mono-, and Dinitrosyl Complexes of Molybdenum with Hydroxylamido(−1), Oximato, Halogeno, and Pseudohalogeno Ligands The compounds [(C6H5)4P]2[Mo(NO)(H2NO)(NCS)4] 1, [(C6H5)4P]2 [Mo(NO)((C2H5)2-CNO)(NCS)4] 2, [(C6H5)4P]2[Mo(NO)2(NCS)4] · CH3OH, 3 [(C6H5)4P]3[Mo(NO)(CN)5] · 2H2O 4, Cs2[Mo(NO)Cl4(H2O)] 5 and Cs2[Mo(NO)Cl5] 6 were prepared and characterized by complete X-ray structure analysis. All complexes have a nearly linear MoNO moiety, whereas in the anions of 1 and 2 a pentagonal-bipyramidal, in 3—6 an octahedral coordination sphere of Mo is present. Complexes with {MoNO}n configuration (n = 4, 5, 6) can be converted into each other by remarkable redox-reactions. Some novel reactions of the hydroxylamido(−1)-ligand (formation of 2 and 3) are discussed very shortly.