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This article describes a medical family therapy approach to working with families of a child with a chronic medical illness. Medical family therapy combines the systemic paradigm of family therapy with the biopsychosocial paradigm of medicine to treat patients and families who are experiencing medical illness or disability. This article describes how family dynamics influence children's health and how children's health influences family dynamics. It then addresses special assessment issues, treatment issues, and collaboration issues for medical therapists when a child has a chronic illness.