1. [Side effects of trimethoprim-sulfamethoxazole in patients with AIDS].
- Author
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Weinke T, Sixt C, de Matos-Marques B, Ruf B, and Pohle HD
- Subjects
- Adult, Aged, Drug Combinations administration & dosage, Drug Combinations adverse effects, Female, Humans, Male, Middle Aged, Pneumonia, Pneumocystis etiology, Retrospective Studies, Sulfamethoxazole administration & dosage, Trimethoprim administration & dosage, Trimethoprim, Sulfamethoxazole Drug Combination, Acquired Immunodeficiency Syndrome complications, Anti-Infective Agents adverse effects, Pneumonia, Pneumocystis drug therapy, Sulfamethoxazole adverse effects, Trimethoprim adverse effects
- Abstract
Forty-nine episodes of Pneumocystis carinii pneumonia, treated with trimethoprim-sulfamethoxazole among 46 patients with AIDS were analysed retrospectively for any side effects. For only two were there insufficient data. There were 39 toxic reactions, 15 of them serious: leukopenia (n = 23), abnormal liver functions (n = 14), skin changes (n = 12), gastrointestinal complaints (n = 10) and thrombocytopenia (n = 9). In nine patients the treatment had to be discontinued, in six of them so early that a switch to pentamidine was necessary. Gastrointestinal symptoms occurred as early as the sixth day of treatment, while leukopenia and thrombocytopenia were first observed after 12-13 days. Despite the high rate of side effects trimethoprim-sulfamethoxazole remains the drugs of choice, other regimens not having been found to be any better.
- Published
- 1988
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