27 results on '"Leukaemia"'
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2. Walter Büngeler (1900–1987): Opfer der NS-Zeit oder nationalsozialistischer Kontaktmann in Brasilien?
- Author
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Schmidt, Mathias, Gräf, Christina, and Groß, Dominik
- Abstract
Copyright of Der Pathologe is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
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3. Investigations into the Potential Role of Metabolites on the Anti-Leukemic Activity of Imatinib, Nilotinib and Midostaurin
- Author
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Paul W. Manley
- Subjects
Imatinib ,Leukaemia ,Metabolite ,Midostaurin ,Nilotinib ,Chemistry ,QD1-999 - Abstract
The efficacy and side-effects of drugs do not just reflect the biochemical and pharmacodynamic properties of the parent compound, but often comprise of cooperative effects between the properties of the parent and active metabolites. Metabolites of imatinib, nilotinib and midostaurin have been synthesised and evaluated in assays to compare their properties as protein kinase inhibitors with the parent drugs. The N-desmethyl-metabolite of imatinib is substantially less active than imatinib as a BCR-ABL1 kinase inhibitor, thus providing an explanation as to why patients producing high levels of this metabolite show a relatively low response rate in chronic myeloid leukaemia (CML) treatment. The hydroxymethylphenyl and N-oxide metabolites of imatinib and nilotinib are only weakly active as BCR-ABL1 inhibitors and are unlikely to play a role in the efficacy of either drug in CML. The 3-(R)-HO-metabolite of midostaurin shows appreciable accumulation following chronic drug administration and, in addition to mutant forms of FLT3, potently inhibits the PDPK1 and VEGFR2 kinases (IC50 values
- Published
- 2019
- Full Text
- View/download PDF
4. Kleinräumige Analyse vermuteter Krebscluster anhand von Krebsregisterdaten.
- Author
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Radespiel-Tröger, M. and Meyer, M.
- Abstract
Copyright of Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
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5. Wichtige Differentialdiagnosen von Lungeninfiltraten bei hämatologischen Patienten
- Author
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Blau, Igor-Wolfgang, Heinz, Werner J., Schwartz, Stefan, Lipp, Hans-Peter, Schafhausen, Philippe, and Maschmeyer, Georg
- Published
- 2018
- Full Text
- View/download PDF
6. [The 5th edition of the WHO classification of lymphoid neoplasms-an overview].
- Author
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Kurz KS and Ott G
- Subjects
- Humans, Pathologists, World Health Organization, Lymphoma, Large B-Cell, Diffuse pathology, Hematopoietic System pathology
- Abstract
The "Blue Book" of the WHO classification of haematolymphoid tumours is the worldwide accepted reference in malignant tumours of the myeloid and lymphoid system. The REAL classification of 1994 [2] laid the foundations for the WHO volumes, with continous development and specification to date [3, 5, 6]. In the 5th edition of the classification to be released this year, new insights concerning the pathogenesis and molecular genetics, and new concepts regarding the taxonomic basis of the classification are included. Overviews of the changes and new aspects of the 5th edition of the classification of haematolymphoid tumours (WHO-HAEM5) have recently been published [1, 4]. Overall, 420 authors participated on the WHO-HAEM5, among them numerous members of the large international societies for haematopathology, the European Association for Haematopathology (EAHP) and the Society for Hematopathology (SH). The WHO-HAEM5 was developed in a multidisciplinary setting in numerous online meetings with haematopathologists, haematologists, oncologists, geneticists, epidemiologists and molecular biologists. In extensive discussions, harmonisation of chapters and with the other volumes of the 5th series was sought. For implementation of clinical aspects, a clinical advisory board was consulted. The new classification constitutes a systematic update of former classifications. As has been implemented earlier, the entities are presented in a hierarchical order: category (e.g. mature B‑cell neoplasm), family/class (e.g. diffuse large B‑cell lymphoma, DLBCL), entity (e.g. DLBCL, not otherwise specified, NOS) and subtype (e.g. DLBCL, NOS, GCB-type). Similar to the 5th editions of other WHO classifications, at the end of each chapter, a list of "essential" diagnostic criteria representing minimal criteria to establish the diagnosis and "desirable" diagnostic criteria are given in order to further confirm and specify the diagnosis., (© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2022
- Full Text
- View/download PDF
7. Natürliche Killerzellen in der Leukämie- und Tumortherapie.
- Author
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Lang, P., Huenecke, S., Pfeiffer, M., Handgretinger, R., and Koehl, U.
- Abstract
Copyright of Monatsschrift Kinderheilkunde is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2010
- Full Text
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8. Hämatopoetische Stammzelltransplantation.
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Sayer, H.G. and Beelen, D.W.
- Abstract
Copyright of Der Onkologe is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2009
- Full Text
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9. Ernährungsstatus krebskranker Kinder während Chemotherapie.
- Author
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Schmid, I., Streiter, M., Schmitt, M., Kauws, F., Kern, T., Mäusl, R., Meilbeck, R., Reinhardt, D., and Stachel, D.
- Abstract
Copyright of Monatsschrift Kinderheilkunde is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2007
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10. Leukämien bei Kindern und Jugendlichen.
- Author
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Göbel, U.
- Abstract
Copyright of Monatsschrift Kinderheilkunde is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2003
- Full Text
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11. Gibt es ein erhöhtes Risiko für Leukämien, Hirntumoren oder Brustkrebs nach Exposition gegenüber Hochfrequenztrahlung?
- Author
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Blettner, Maria and Schlehofer, Brigitte
- Abstract
Copyright of Medizinische Klinik (Urban & Vogel) is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 1999
- Full Text
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12. Septikämien bei Leukämien und malignen Lymphomen.
- Author
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Hennemann, H.
- Abstract
Septicemia ocurred in 81 (=23.9%) of 339 patients with leukemias an malignant lymphomas during 1979-1984/VI. In leukemias the acute forms and in malignant lymphomas the high malignant forms were mostly affected. The frequency of gramnegative bacterias (46=56.8%) was higher than that of gram-positive bacterias (32=39.5%) and of fungus (3=3.7%). The frequency of septicemia in leukemias (alone) between 1966-1977 was 13.9%, between 1979-1984/VI 30%. In this comparison septicemias caused by gram-negative bacterias and fungus decreased, whereas gram-positive septicemias increased. The focus of septicemia remained unknown in 30 cases, Pneumonias and the urinary tract were the most common source, followed by the skin. All patients were under cytostatics and therefore leukopenic, most of them received corticosteroids simultaneously and were thus immunsuppressed. A combination of granulocytopenia <1,000 mm with hypogammaglobulinemia <10 rel.% were mostly found in acute leukemias and in chronic lymphatic leukemia. 41.5% of febrile episodes from all groupes of these diseases were of non-microbic origin (local or septic) an thus possibly symptom of activity of the underlying disease. [ABSTRACT FROM AUTHOR]
- Published
- 1985
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13. Chromosomenanomalien und Tumorentstehung.
- Author
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Zankl, H. and Zang, K.
- Abstract
Copyright of Klinische Wochenschrift is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 1978
- Full Text
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14. Untersuchungen der Lysozymaktivität in Serum, Urin und Blutausstrichen von Patienten mit hämatologischen Erkrankungen.
- Author
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Labedzki, L., Seché, G., and Lorbacher, P.
- Abstract
Copyright of Klinische Wochenschrift is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 1977
- Full Text
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15. Zellcyclusänderungen und ineffektive Zellneubildung bei gestörter Granulo- und Erythropoese.
- Author
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Müller, D., Reichert, E., Lang, H., and Orywall, D.
- Abstract
Copyright of Klinische Wochenschrift is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 1974
- Full Text
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16. Muramidaseaktivität in Leukocyten und Plasma bei Krankheiten mit verminderter Infektabwehr.
- Author
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Panizzon, R. and Senn, H.
- Abstract
Copyright of Klinische Wochenschrift is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 1973
- Full Text
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17. Nachweis und Aktivität der Methioninsynthetase in normalen und pathologischen Zellen des Blutes und des Knochenmarks.
- Author
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Bloos, I. and Sauer, H.
- Abstract
Copyright of Klinische Wochenschrift is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 1972
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18. [Walter Büngeler (1900-1987) : Nazi victim or political influencer in Brazil?]
- Author
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Schmidt M, Gräf C, and Groß D
- Subjects
- Brazil, Europe, Germany, History, 20th Century, Humans, Universities, National Socialism, Pathologists history
- Abstract
Walter Büngeler is one of the best known German pathologists of the 20th century. He became internationally known for his basic research on leukaemia and the pathology of tumours. In 1936 he left Europe for Brazil but returned in 1942. After 1945, he staged himself as a political victim who had been expelled first by the National Socialists and later from Brazil. In fact, with this portrayal he succeeded in passing the denazification procedure without any damage and in continuing and considerably expanding his university career. Until the recent past, Büngeler was described in the relevant literature as a Nazi critic or victim. But does the presentation handed down by Büngeler stand up to a critical examination of the facts?On the basis of contemporary sources, the article reveals serious differences between Büngeler's statements and historical facts. It can be shown that Büngeler's allegations in denazification were incorrect in all relevant aspects.
- Published
- 2020
- Full Text
- View/download PDF
19. Hämatopoetische Stammzelltransplantation: Indikationen, Ergebnisse und Entwicklungsperspektiven
- Author
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Sayer, H.G. and Beelen, D.W.
- Published
- 2009
- Full Text
- View/download PDF
20. Diagnostik und Therapiestrategien bei Leukämien
- Author
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Zettl, Florian and Hohloch, Karin
- Published
- 2003
- Full Text
- View/download PDF
21. Wie nutzen Patienten das Internet nach einer allogenen Stammzelltransplantation?
- Author
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Röttger, Klaus F., Düllmann, Sonja, Beelen, Dietrich, Senf, Wolfgang, and Tagay, Sefik
- Subjects
haematopoietic disease ,Krebs ,haematopoietic stem cell transplantation ,Medizin ,internet use ,physician-patient communication ,Arzt-Patient-Kommunikation ,Leukämie ,Medizinische Fakultät ,Internetnutzung ,leukaemia ,ddc:61 ,cancer ,ddc:610 ,hämatologische Erkrankung ,Stammzelltransplantation - Abstract
Hintergrund und Fragestellung: Das Internet als moderne Informations- und Kommunikationstechnologie spielt für die Gewinnung erkrankungsbezogenen Informationen und somit auch für die Arzt-Patienten-Kommunikation eine nicht mehr zu vernachlässigende Rolle [7,14]. Bei der allogenen hämatopoetischen Stammzelltransplantation (HSZT) handelt es sich um ein sehr aufwändiges, kostenintensives Behandlungsverfahren bei dem Langzeitfolgen Monate bis Jahre nach der Transplantation auftreten können [12]. In jedem Fall ist eine lebenslange medizinische Nachsorge indiziert. Diese Arbeit hatte zum Ziel, grundlegende Aspekte der erkrankungsbezogenen Internetnutzung von allogen stammzelltransplantierten Patienten vor allem in der Zeit der ambulanten Nachsorge zu eruieren. Methoden: 117 allogen stammzelltransplantierte Patienten (47% männlich, mittleres Alter: Männer 45,1; Frauen 46,9) mit der Grunderkrankung einer akuten oder chronischen Leukämie (Männer 80%; Frauen 67,8%) bzw. einer anderen malignen Erkrankung des blutbildenden Systems wurden in die Studie einbezogen und mit Hilfe eines selbst entwickelten und in Papierform vorliegenden Fragebogens im Rahmen eines quasiprospektiven Designs in der Zeit der Nachsorge zu ihrer allgemeinen und erkrankungsbezogenen Internetnutzung befragt. Ergebnisse: Von den Studienteilnehmern nutzten 72,6% das Internet auch erkrankungsbezogen. 77,6% davon haben seit mehr als fünf Jahren Internetzugang, 91,8% fühlen sich vertraut bis sehr vertraut im Umgang mit dem Medium und 62,4% sind täglich online. Der Anteil der Internetnutzer liegt bei den Männern um 21,4% und bei den Frauen um 30% über den Vergleichsdaten der bundesdeutschen Bevölkerung [4]. Von jüngeren Befragten, denjenigen mit höherem Bildungsgrad sowie in der Zeit 13 bis 60 Monate nach allogener Stammzelltransplantation wird das Internet besonders intensiv erkrankungsbezogen genutzt. Die Zusammenhänge der erkrankungsbezogenen Internetnutzung mit sozialdemografischen und medizinischen Daten wurden im Hinblick auf einzelne Recherchethemen ermittelt und stellen sich differenziert dar. Vorrangig werden Informationen zum Themenbereich „Erkrankung und Behandlung“ gesucht. Bemerkenswert ist aber, dass die Suche nach Erfahrungsberichten anderer Betroffener an sechster Stelle rangiert, und dass der am zweithäufigsten genannte Einstieg in das Internet über die Homepage einer Klinik erfolgt. Folgerungen: Die Betroffenen sehen sich vielfach als „Experten ihrer Erkrankung und Behandlung“. Die Patienten kennen sich mit Diagnostik und Behandlung, z.B. mit den eigenen Blutwerten, gut aus und sind bereit, sich sehr eingreifenden Behandlungen zu unterziehen [30]. Da stammzelltransplantierte Patienten im Vergleich zu Krebs- oder Leukämiekranken im Mittel über 20 Jahre jünger sind als dies nach dem Altersmedian der entsprechenden Erkrankungen in der Bevölkerung zu erwarten wäre [26], und jüngere Menschen das Internet intensiver nutzen als ältere [4], ist es plausibel, dass der Anteil der Internetnutzer in dieser Studie bei den Männern um 21,4% und bei den Frauen um 30% über den Vergleichsdaten der bundesdeutschen Bevölkerung [4] liegt. Im Hinblick auf die Ansprüche an erkrankungsbezogene Informationen und die Arzt-Patient-Kommunikation ist die Nutzung des Mediums Internet durch dieses Patientenkollektiv zu reflektieren. The aim of the study was to explore the health-related internet use by patients after allogen hematopoetic stemcelltransplantation. 177 allogen stemcelltransplantated patients answered the paper-based questionnaire set with 110 items. This comprised three developed questionnaire modules referring to the socialdemographic data, the medical data and the internet use. 85 (72.6%) of the study participants use the Internet also illness-referred. 77.6% of them have had internet access for more than five years, 91.8% are familiar to very familiar with handling the medium and 62.4% are on-line daily. The internet use among the men is around 21.4% and among the women around 30% higher than the comparative data of the ARD/ZDF on-line study 2009. The internet is obviously more intensely used by the younger participants who have reached a higher education degree, as well as by those participants in the time 13-60 months after HSZT. The significance of the connections between the illness-referred internet use and socialdemographic and medical data was determined regarding individual search topics and is demonstrated in a differentiated way.
- Published
- 2011
22. Optimierung der Liquorproteinelektrophorese in Agarosegel
- Author
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Barnard, Karin
- Subjects
neuropaediatrics ,childern ,Leukaemia ,normal values ,agarose gel electrophoresis ,Transthyretin ,cerebrospinal fluid ,proteins - Abstract
Veränderungen der Proteinkonzentrationen des Liquors cerebrospinalis sind einerseits abhängig von physiologischen Faktoren wie Lebensalter und Abnahmeort, andererseits spiegeln sie pathologische Prozesse wie zum Beispiel die Störung der Blut-Liquor-Schranke (BLS) wieder. Um diese pathologischen Vorgänge zu erkennen, wird ein Stufenprogramm, bestehend aus Erst-, Basis- und Spezialdiagnostik, zur Liquoranalytik eingesetzt. Die hier optimierte Liquorelektrophorese in Agarosegel wurde zur quantitativen Analyse von sechs Liquorproteine bzw. Proteingruppen (Transthyretin, Albumin, α 2-Proteine, β 1- Pro-teine, τ-Fraktion, γ-Globuline) als Ergänzung der Basisdiagnostik von neuropädia-trischen Erkrankungen eingesetzt. Basis hierfür waren: Liquorproteinkonzentrierung ohne spezifischen Eiweißverlust, Reproduzierbarkeit Elektrophoresebedingungen, lineare Proteinanfärbung durch den Farbstoff Amidoschwarz, computergesteuerte quantitative Auswertung mittels Densitometrie und Gaußapproximierung sowie die Erstellung von altersabhängigen Normalwerten für die untersuchten Proteine/ Proteingruppen im Liquor. Die neu aufgestellten Normalwerte galten als Referenz und als Normalabgleich bei der Untersuchung der pathologischen Liquorproben. Alle hier untersuchten Krankheitsbilder unter-schieden sich im Proteinmuster der Liquorelektrophorese. Analysiert wurden Kinder, die an einem Guillain Barré Syndrom (GBS), einer Neuroborreliose, einer bakteriellen Meningitis und einer Retardierung mit Vergrößerung der Liquorräume litten sowie Kinder vor und während der Therapie einer akuten Leukämie. Als besonders aussagekräftige Parameter einer BLS Störung erwiesen sich die relativen Veränderungen der hauptsächlich zentral synthetisierten Proteine Transthyretin und die τ-Fraktion sowie die absoluten Veränderungen der aus dem Serum stammenden Proteine Albumin und γ-Globuline (Immunglobulin G). Anhalt auf eine intrathekale Bildung des Immunglobulins G konnte durch optische Betrachtung der Elektrophorese sowie durch relative und absolute Konzentrationsveränderungen gegenüber den altersabhängigen γ-Globulin Normalwerten gewonnen werden. Es konnte gezeigt werden, dass während Polychemotherapie der akuten Leukämie, Glucocorticosteroide einen protektiven Einfluss auf die BLS Funktion zu haben scheinen. Die Bedeutung besonders der Transthyretinfraktion in der altersabhängigen Beurteilung BLS Funktion im Sinne einer vermehrten Durchlässigkeit sowie einer Verdichtung der Schrankenfunktion wurde dargestellt. Die Transthyretinfraktion kann ein sensitiver Marker zur Beurteilung der BLS Funktion zum Beispiel am Beginn eines GBS sein. Es wurde gezeigt, dass die Berücksichtigung des gesamten elektrophoretischen Proteinmusters mit seinen altersbezogenen Parametern Transthyretin, Albumin, α 2-Proteine, β 1- Protein (Transferrin), τ-Fraktion und dem γ-Globulin (IgG) relevante klinische Bedeutung für die Liquorbasisdiagnostik neuropädiatrischer Krankheiten haben kann und besonders zur Analyse der BLS-Funktion genutzt werden könnte. Das her-kömmliche Basisprogramm der Liquorproteindiagnostik könnte durch die Liquorprotein- elektrophorese in Agarosegel erweitert werden., Changes of protein levels in the cerebrospinal fluid (CSF) depend not only on physiological factors such as age and site of sampling, but can also reflect pathological processes. To detect these pathological alterations in the CSF a phase program consisting of primary, basic and special diagnostics is commonly used. An optimised process of electrophoresis of CSF proteins in agarose gel was used to quantify six CSF proteins or groups of proteins (transthyretin, albumin, α 2-proteins, β 1-protein, τ-fraction, γ-globulin) to complement the basic program of CSF analysis used to diagnose neuropaediatric disorders. The basis of this analysis was: Concentration of CSF proteins without a specific protein loss, reproducibility of electrophoresis, linear protein staining with amido-black dye, computerised quantitative analysis of the electrophoresis using densitometry and Gaussian curve approximation as well as establishing age-dependent normal values for the studied proteins / protein groups in the CSF gained by the electrophoresis. The newly established normal values were reference and base in the investigation of pathological CSF samples. All diseases examined differed in the CSF protein electrophoresis pattern. Analysis was conducted of children who were suffering from Guillain Barré syndrome, neuroborreliosis, bacterial meningitis and retardation with enlargement of CSF spaces, as well as children before and during therapy for acute leukaemia. The relative changes of the mainly centrally-synthesized proteins transthyretin and τ-fraction as well as the absolute changes of the serum-originated proteins albumin and γ-globulin (immunoglobulin G) proved to be particularly good markers to assess blood-CSF barrier function. For an approximate detection of intrathecal immunoreaction of immunoglobulin G optical analysis of the electrophoresis as well as comparison of relative and absolute changes in the γ-globulin fraction compared to the age-dependent normal values proved to be useful. It was shown that during poly-chemotherapy of acute leukaemia, glucocorticosteroids might have a protective effect on the blood-CSF barrier function. The importance of the transthyretin fraction particularly in the assessment of age-dependent blood-CSF barrier function in terms of increased permeability and a tightening of the barrier function was analysed. Transthyretin can be a sensitive marker to detect blood-CSF barrier disturbances, for example at the start of Guillain Barré Syndrome. It was shown that consideration of the entire age-dependent electrophoretic protein pattern with the parameters, transthyretin, albumin, α 2-proteins, β 1-protein (transferrin), τ-fraction and γ-globulin fraction (immunoglobulin G) may have additional clinical relevance in the diagnosis of neuropaediatric diseases and could especially be used to analyse the BLS function. The conventional base program of CSF protein analysis could be expanded by electrophoresis of CSF proteins in agarose gel.
- Published
- 2011
23. Akute myeloische Leukämie nach Mitoxantronbehandlung von Patienten mit Multipler Sklerose
- Author
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Kragler, Michael, Franke, Christian (Prof. Dr. Dr.), Conrad, Bastian (Prof. Dr.), and Neumeier, Dieter (Prof. Dr.)
- Subjects
multiple sclerosis ,mitoxantrone ,therapy ,leukaemia ,Medizin ,Multiple Sklerose ,Mitoxantron ,Therapie ,Leukämie ,tAML ,ddc:610 - Abstract
Das Risiko für MS-Patienten nach Behandlung mit Mitoxantron an sekundären Leukämien zu erkranken wurde bisher sehr gering eingeschätzt. In der vorliegenden Arbeit werden drei Fälle von tAML nach Mitoxantronbehandlung bei MS-Patienten vorgestellt. Die Daten der bislang bekannten 14 Fälle von tAML, werden mit denen von MS-Patienten verglichen, die ebenfalls mit Mitoxantron behandelt wurden. Die Ergebnisse legen nahe, dass ein Zusammenhang zwischen dem Erkankungsrisiko und der kumulativen Mitoxantrondosis besteht. Für eine definierte Population errechnet sich eine Inzidenz an tAML zu erkranken von 0,7% (95% Konfidenzintervall 0,2% - 3,9%). The risk of developing therapy-related acute myeloid leukaemia (tAML) after mitoxantrone treatment has been judged as insignificant by now. Three new cases of tAML after mitoxantrone treatment are reported. Data of the 14 published cases of tAML is compared with data of MS patients not having developed tAML after mitoxantrone treatment. It seems that a correlation between the appearance of tAML and the cumulative dose of mitoxantrone exists. The investigated group of patients shows an incidence of tAML of 0,7%.
- Published
- 2006
24. [Pulmonary infiltrates in haematological patients].
- Author
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Blau IW, Heinz WJ, Schwartz S, Lipp HP, Schafhausen P, and Maschmeyer G
- Subjects
- Anti-Bacterial Agents therapeutic use, Bacterial Infections complications, Bacterial Infections diagnosis, Bacterial Infections drug therapy, Bacterial Infections microbiology, Humans, Respiratory Tract Infections diagnosis, Respiratory Tract Infections drug therapy, Respiratory Tract Infections microbiology, Hematologic Neoplasms complications, Respiratory Tract Infections complications
- Abstract
Background: Pulmonary complications are frequent in haematologic patients., Method: This review article summarizes the outcome of a discussion that took place during an expert meeting on the subject of pulmonary infiltrates., Results and Conclusions: The most common causes of pulmonary infiltrates in haematologic patients are bacterial infections. Viral infections are subject to relevant seasonal variations, but they may also cause an important proportion of pulmonary infiltrates. Microbiological examination of respiratory tract material (if possible, bronchoalveolar lavage, BAL) is the most important diagnostic procedure. Particularly in the case of prolonged (> 7 days) neutropenia, the likelihood of infiltrates being caused by fungal infections increases. For a differential diagnosis, however, also non-infectious causes, e.g. drug-induced infiltrates, have to be taken into consideration. The diagnostic workup, however, should not delay a timely start of an adequate antimicrobial therapy.
- Published
- 2018
- Full Text
- View/download PDF
25. [Small-scale analysis of suspected cancer clusters based on cancer registry data].
- Author
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Radespiel-Tröger M and Meyer M
- Subjects
- Adult, Causality, Child, Correlation of Data, Germany, Guideline Adherence, Health Education, Humans, Leukemia therapy, Neoplasms therapy, Prevalence, Risk Assessment, Cluster Analysis, Leukemia epidemiology, Neoplasms epidemiology, Registries statistics & numerical data, Small-Area Analysis
- Abstract
Cancer registries collect data about the occurrence and temporal changes of the occurrence of all types of cancer. This information is an important basis for health administration as well as for the evaluation of possible cancer causes. Cancer clusters can be detected by analysis of registry data according to place or district of residence of diseased persons. Cancer registries frequently receive enquiries from concerned citizens asking for investigation of the causes of suspected cancer clusters. The management of suspected cancer clusters can be described as crisis management due to the mixing of medical, biological, political, and psychological factors. In this article, we present an overview of current guidelines and methods for handling suspected cancer clusters by cancer registries. Moreover, the numerical analysis of small-scale cancer registry data is illustrated using two examples from the Bavarian Cancer Registry.
- Published
- 2017
- Full Text
- View/download PDF
26. [Extreme neutrophilia in cats - aetiology and prognosis].
- Author
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Langenstein J, Bauer N, and Moritz A
- Subjects
- Animals, Cats, Leukemia blood, Leukemia diagnosis, Leukocyte Disorders diagnosis, Leukocyte Disorders pathology, Prognosis, Retrospective Studies, Cat Diseases blood, Cat Diseases pathology, Leukemia veterinary, Leukocyte Disorders veterinary, Neutrophils pathology
- Abstract
Objective: The aim of this retrospective study was to evaluate the aetiology and prognostic factors of extreme neutrophilia in cats., Material and Methods: Patient data over a 5-year period (January 2008 - December 2013) were reviewed. Cats with a neutrophil count > 40 x 10⁹/l were included. They were further assigned to four groups: "inflammation", "neoplasia", "immune-mediated diseases", "unknown aetiology". Clinical signs, rectal temperature, hospitalisation, duration of hospitalisation, survival, left-shift and toxicity of neutrophils were evaluated., Results: In total, 28/5185 cats (0.5%) displayed extreme neutrophilia with a mean neutrophil count of 48.5 x 10⁹/l (40.0-76.0 x 10⁹/l). The most common aetiology was a severe inflammation, as seen in 16/28 cats (57%), whereby peritonitis (5/15 cats, 31%) predominated. In cats with neoplastic diseases (9/28 cats, 32%), intestinal neoplasia with subsequent peritonitis was the most common diagnosis (4/9 cats, 44%). Diseases of unknown aetiology (2/28 cats, 7%) and immune-mediated diseases (1/28, 3.6%) were rare. The most common clinical indications included lethargy, anorexia, fever, and gastrointestinal signs. Rectal temperature ranged between 33.9 °C and 40.2 °C, whereby in 2/24 cats (8%) hyperthermia (> 39.3°C) and in 5/24 cats (21%) hypothermia (< 38.0°C) was observed. Hospitalisation occurred in 21/28 cats (75%) with a median duration of 5.5 days (1-30 days). In 24/28 cats, a manual differential count was performed. A left-shift and toxicity of neutrophils were seen in 23/24 cats (96%) and 21/24 cats (88%), respectively. The overall median survival rate was 50%, whereby the survival rate was significantly lower in cats with neoplasia than in those with inflammatory diseases (22% vs. 56%, p < 0.0001)., Clinical Relevance: An extreme neutrophilia is rare. It is commonly caused by peritonitis due to foreign bodies or ruptured intestinal tumours (in particular, intestinal lymphomas) and is characterised by a high mortality.
- Published
- 2015
- Full Text
- View/download PDF
27. [Equine leukaemic lymphoma--a rare form of equine lymphoma].
- Author
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Winter J, Kershaw O, Schmitz R, and Gehlen H
- Subjects
- Animals, Horse Diseases diagnostic imaging, Horses, Leukemia diagnostic imaging, Leukemia pathology, Lymphoma diagnostic imaging, Lymphoma pathology, Ultrasonography, Horse Diseases pathology, Leukemia veterinary, Lymphoma veterinary
- Abstract
Equine leukaemic lymphoma is a rare disease of the haematopoetic tissue. It results from neoplastic degradation of B- and T-lymphocytes and their occurrence in the blood. Clinical signs are often unspecific and include chronic weight loss, ventral oedema at the thorax and abdomen and regional lymphadenopathy. Horses are often presented late in the course of the disease and therapy is rarely successful. This review summarizes the clinical pathologic findings of equine leukaemic lymphoma and the findings of laboratory testing and other diagnostic measures, and presents treatment options described in the literature.
- Published
- 2014
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