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In this article, the prevalence of the Morbus Wilson disease in Germany is determined. This is based on nationwide data of drug prescriptions and contractional data of outpatient offices. The prevalence is set in ratio to the found prevalence of prescriptions in Germany. The descriptive evaluation is based on the database of the Central Research Institute of Ambulatory Health Care (Zi) in Germany. Additionally, data of the Federal Office of Statistics regarding inpatient treatment are available. It can be seen that there is a notable difference between the prevalence of patients undergoing therapy and the patients with verified diagnoses. In total, prevalence is increasing. The incidence on hand and the given dynamic of the patient population could indicate that, possibly, there is an increased rate of misdiagnosis in the first year of diagnosis. According to data, the hepatic form is the more often diagnosed form. The human genetic diagnostic increases, on average, are most distinct. Wilson Disease, Prevalence, Incidence, Trientine, Trientintetrahydrochlorid, D-Penicillamin, Zinc acetat, Zinc.EINFüHRUNG: In diesem Beitrag wird die Prävalenz der Erkrankung „Morbus Wilson“ in Deutschland auf der Grundlage von bundesweiten Arzneiverordnungsdaten und vertragsärztlichen Abrechnungsdaten ermittelt und in ein Verhältnis zu der in Deutschland ermittelten Verordnungshäufigkeit gesetzt. METHODIK: Für die deskriptive Darstellung der Abrechnungsdaten wird die Datenbank des Zentralinstituts für die kassenärztliche Versorgung (Zi) genutzt. Weiterhin liegen Daten des Statistischen Bundesamts über die stationäre Behandlung vor. ERGEBNISSE: Auffällig ist die Differenz zwischen den Prävalenzen der therapierten Patienten und der ermittelten gesicherten Diagnosen. Die Prävalenz insgesamt steigt. Die ermittelte Inzidenz und die Betrachtung der Dynamik der Patientenpopulation könnten möglicherweise auf eine hohe Fehldiagnostikrate im ersten Erkrankungsjahr schließen lassen. Nach Datenlage ist die hepatische Verlaufsform die häufigere diagnostizierte Verlaufsform. Die humangenetische Diagnose steigt im Durchschnitt am deutlichsten an. SCHLAGWöRTER: Morbus Wilson, Prävalenz, Inzidenz, Trientine, Trientintetrahydrochlorid, D-Penicillamin, Zinkacetat, Zink.

In the recent discussion of tax theory and policy there has been increasing interest especially for two topics. First, the revenues are again stronger embedded in a macro-economic framework. Second, the relationship between the state and private enterprises is intensively studied. Our paper is in line with this development. Tax reductions for enterprises are used as exogenous parameters. Their influence on employment and output will be shown. In contrast to the traditional supply-side-economics, based on neo-classical calculus, we choose a general equilibrium model with quantity rationing to deduct our results. The analysis concludes that in the case of tax reductions for enterprises different effects on employment will occur, depending on the unemployment situation by which the market or economy is characterized. Using tax policy thus requires a wide range of information for the political decision maker. The advice from supply-side-economists to reduce taxes for enterprises in an unemployment situation can only be considered as adequate in one special unemployment situation.