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This article summarizes the background and a few preliminary results concerning project 7 of the NCCR Chemical Biology. The general objective is to explore new concepts for cellular uptake, membrane tunneling, sensing and labeling. Emphasis is on the use of dynamic covalent chemistry for counterion activation, slow release of polyions and fluorescent probes, and the generation of activator libraries and polyions that grow and shrink.

This year, the CUSO Summer School in Organic Chemistry celebrated its 40th anniversary. With a coinciding 450th anniversary, it was organized by the University of Geneva. The focus was on large molecules and supramolecules that are synthesized from scratch, have interesting functions, and address lessons from nature.