1. [Endocrinological mechanisms in the pathophysiology of hidradenitis suppurativa].
- Author
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Nikolakis G, Karagiannidis I, Vaiopoulos AG, Becker M, and Zouboulis CC
- Subjects
- Androgen Antagonists therapeutic use, Diabetes Mellitus metabolism, Dyslipidemias metabolism, Hair Follicle, Hidradenitis Suppurativa drug therapy, Hidradenitis Suppurativa metabolism, Hormones therapeutic use, Humans, Immunosuppressive Agents therapeutic use, Obesity metabolism, Abscess etiology, Endocrine System Diseases metabolism, Gonadal Steroid Hormones metabolism, Hidradenitis Suppurativa physiopathology, Metabolic Syndrome metabolism
- Abstract
Hidradenitis suppurativa (HS) is a chronic, recurrent cutaneous disease of the terminal hair follicle which manifests with deep-seated, painful nodules, abscesses, and sinus tract formation. The pathophysiology of the disease includes among various factors also dermatoendocrinologic variables: Correlations with metabolic syndrome, obesity, sex steroid hormones, and the improvement after antiandrogen therapy are some of the key points presented in this review. Hormonal treatment of HS can be an effective and inexpensive alternative or add-on therapy to classic HS treatments, especially in cases where antibiotics and/or biologics are ineffective or contraindicated.
- Published
- 2020
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