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By estimation of PAG level from 33 primipara, 20 second-para and 11 third-para it was investigated if there are a correlation between PAG concentration and the number of gravidity or the weight of newborn respectively. The PAG concentration was estimated by so called Laurell electrophoresis and expressed in mm precipitate column. The middle concentration of PAG disclose in primipara 24,7, in second-para 23,0 and in third-para 21,1 mm. The average weight of newborn was to found a contrary tendency. The difference of PAG level between primi- and third-para was statistically significant.

Length of uterus, anterior-posterior and cross diameter in 105 healthy and 101 diabetic girls at the age from 9 to 20 years determined by ultrasound. Length of uterus and its calculated volume are correlated to age and Tanner classification, in order to conceive in a reproducable way the development of uterus in puberty. In both groups a clear push of growth occurs about the time of menarche. The diabetic girls showed a slight delay of uterus development, which is adjusted, however, at the end of puberty (Tanner IV and V).

The sonographically determined length of uterus in 100 insulin-dependent diabetic girls of the age-classes 1964 to 1974 are considered in relation to diabetes mellitus. In order to recognise the possibility of a disturbed development of the inner genitals during puberty of juvenile diabetics, the uterus development is considered in relation to ossification age, duration of diabetes, and to the period before or after the 10th year of age as well as before respectively after menarche. Before the 16th year of age the growth curves of the uterus in all metabolism groups show non-significant delays, which are difficult to interpret. Up to the 18th year the course of the curves reach a similar standard of development--that is an average of 60 mm. In order to determine the precise moment of the diagnostic and therapeutic activity in delayed puberty development, it seems to us appropriate to use the sonographic measurement of the uterus length in addition to the definition of ossification age.