1. [Large cell anaplastic lymphomas in the immunocompromised host].
- Author
-
Borisch B, Fey MF, Tobler A, Bürki K, Gatter KC, and Wainscoat JS
- Subjects
- Antigens, CD analysis, Antigens, Neoplasm analysis, Autopsy, Biopsy, Blotting, Southern, DNA, Viral genetics, DNA, Viral isolation & purification, Herpesviridae Infections complications, Herpesviridae Infections pathology, Herpesvirus 4, Human genetics, Herpesvirus 4, Human isolation & purification, Humans, Ki-1 Antigen, Lymphoma, Large B-Cell, Diffuse etiology, Lymphoma, Large B-Cell, Diffuse immunology, Restriction Mapping, Immunocompromised Host, Immunosuppression Therapy adverse effects, Kidney Transplantation immunology, Lymphoma, Large B-Cell, Diffuse pathology
- Abstract
Large cell anaplastic (LCA) lymphomas are a newly defined tumor entity, which has recently been integrated in the updated Kiel classification. The occurrence of CD30+ LCA lymphoma in the setting of renal transplant patients has so far been reported only once. This report describes two LCA lymphomas of B-cell phenotype in renal transplant patients. The clonal evolution and possible etiologic role of Epstein-Barr Virus (EBV) in LCA lymphoma was studied. Our findings give further evidence that clonal evolution of B-cell populations is a second event in lymphomagenesis and is, at least in the cases studied, preceeded by either reactivated latent or primary EBV-infection with clonal EBV proliferation.
- Published
- 1991