1. [Experimental studies on the therapeutic modification of intestinal adhesion formation].
- Author
-
Abdalla HM, El Ghorory M, Ali SA, Ghaly AF, and Fares R
- Subjects
- Animals, Chlorpheniramine administration & dosage, Clinical Trials as Topic, Humans, Male, Methylprednisolone administration & dosage, Postoperative Care, Preoperative Care, Rats, Anti-Inflammatory Agents administration & dosage, Peptide Hydrolases administration & dosage, Peritoneum, Tissue Adhesions prevention & control
- Abstract
One of the main problems encountered by the surgeon are visceral adhesions after abdominal surgery. This problem was studied in animal experiments by inducing peritoneal adhesions in 30 albino rats. The anti-inflammatory, resp. anti-adhesive effect of corticosteroids and antihistamines was tested by application of these drugs before, resp. after surgery. Anti-inflammatory proteolytic enzymes (Wobe-Mugos) were applied pre-, resp. postoperatively in two other groups. A fifth group served as controls. A modified cotton-pellet technique was used for the experiments. The best results were achieved when "Wobe-Mugos" was applied after surgery.
- Published
- 1978