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Purpose: Most of the studies on radial optic neurotomy (RON) have not defined the depth of the incision. Complications following a deeper incision have been described. This histological study was performed to evaluate the required depth for RON., Methods: Serial sections of the area of the optic nerve head were performed in 19 eye bank eyes. The distance between the inner surface of the optic disc and the outer limit of the cribriform plate was measured. Ten additional eye bank eyes underwent 2 mm deep experimental RON using the Spaide CRVO Knife (DORC, Netherlands). The cutting depth was assessed histologically by serial cuts., Results: The distance between the inner surface of the disc and the outer limit of the cribriform plate measured 1.35+/-0.3 mm (shrinkage-revised value: 1.45 mm). The experimental RON showed cutting depths of 1.53+/-0.3 mm (shrinkage-revised value: 1.65 mm)., Conclusion: Based on normal eyes, a cutting depth of 1.45 mm is sufficient to cut through the cribriform plate. This might change during central retinal vein occlusion because possible papillary edema due to central retinal vein occlusion has to be considered. Even under controlled experimental conditions RON leads to great variation in incision depths. The development of a knife with a fixed penetration depth would be helpful.

The excision of tumors of the pituitary gland is usually achieved via a transsphenoidal transnasal approach. In the past, alternative approaches were described for macroadenomas. Especially in tumors surrounding the internal carotid artery (ICA) and the optic nerve, the selection of the appropriate approach is of importance. We demonstrate the case of a second extensive relapse of a macroadenoma after primary transsphenoidal resection and radiation therapy. As the tumor enclosed both the ICA and left optic nerve, a median external approach via the upper midface was chosen. After the median skin incision and translocation of the upper parts of the nasal structure, the papyraceous lamina was removed bilaterally. The orbital tissue was laterally exposed with retractors, achieving a wide access to both carotids and optic nerves. The functional and aesthetic results were satisfactory. Compared with other approaches, this one provides a good exposure of both the ICA and optic nerve.

The incidence of intraosseous hemangiomas is very low. Most of them occur in adult females. The mandible,the zygoma,the maxilla, and the frontal and nasal bones are the areas of most frequent localization in the facial region. The intraosseous hemangioma is a benign, slowly growing,bony hard tumor causing facial deformity. It is diagnosed histologically. We report a case of an 18-year-old male with an intraosseous cavernous hemangioma located in the perpendicular lamina of the ethmoid bone. Intraosseous hemangioma often has characteristic signs on a CT scan, with either coarsened trabeculae lying adjacent to the vascular channels or multifocal lytic areas creating a honeycomb pattern. Because of the age of the patient we considered a midline granuloma and a chondrosarcoma. The therapy of choice is surgical excision; radiation is done in exceptional cases only.

Computed tomography (CT) is a very important diagnostic tool prior to endoscopic nasal or paranasal sinus surgery. However, it is frequently notice during endonsal surgery of the paranasal sinuses, that the intraoperative results do not completely agree with the radiological ones. The objective of the present study was to compare clinical and operative findings with those of CT investigations. We collected 200 cases treated during the past 2 years and studied their CT reports. Paranasal sinuses were separated into six regions, and the pathological changes due to sinusitis found by CT were classified into four groups. Altogether, we found a highly significant relationship between CT and intraoperative findings (r = 0.44; P < 0.0001), but differences were found in several regions. The highest correlation was found in the anterior ethmoid bone area (r = 0.98), posterior ethmoid bone area (r = 0.53), maxillary sinus (r = 0.36) and sphenoid sinus (r = 0.35). There was only a low agreement in the case of frontal sinus and recessus frontalis. Possible factors such as time between CT and operation or inflammation are discussed. While CT is the image modality of choice in evaluating patients with chronic paranasal sinusitis, agreement to intraoperative findings is not perfect. This should be taken into consideration when planning functional endoscopic sinus surgery.

Background: Acute sinusitis usually requires conservative treatment with antibiotics and decongestion nose drops. However, a certain number of cases do not respond to that treatment. Because functional endoscopic endonasal sinus surgery (FESS) has been proven to be a valuable tool in treatment of all kind of chronic sinus diseases, it was adopted for acute complicated sinusitis., Methods: Between 1990 and 1993, ethmoidectomy was performed in 43 patients with acute inflammatory sinus disease in whom conservative treatment had failed (frontal sinusitis n = 11, max. sinusitis n = 10, isolated ethmoiditis n = 5, orbital complications of sinusitis n = 10, sphenoidsinusitis n = 2, acute pyomucocele n = 5). Coronal CT scan revealed mucosal pathology of the ethmoid region in 41 cases. None of the patients had intranasal polyposis. Complete ethmoidectomy was performed under general anesthesia using an endoscope and the transnasal route., Results: All patients had relief of their symptoms within the first two postoperative days. One patient with a mucocele and two patients with orbital complications following osteoplastic procedures required revision surgery for removal of screws and plates from previous surgery. None of the patients developed recurrent symptoms of acute complicated sinusitis within the mean postoperative observation period of nine months., Conclusion: FESS should early be considered as a possible treatment of acute sinusitis and its complications if conservative treatment fails.

As long as cribra orbitalia manifests itself as an isolated skeletal lesion in excavated human skeletons, it is mostly diagnosed as being of nutritional origin, especially iron deficiency anemia. Since both iron and vitamin C function as cofactors at the hydroxylation of the amino acids proline and lysine in collagen, both amino acid analyses of bone collagen and the determination of bone mineral iron content was carried out at ten medieval skeletons with cribra orbitalia, opposed to ten morphologically healthy individuals from the same skeletal series. The skeletons with cribra orbitalia were significantly depleted with respect to OHpro (the OHpro/Pro-ratio being 16.9% lower than in the control group), but did not differ from the healthy individuals with respect to OHlys and iron content. No correlation was found between proline hydroxylation and age at death or degree of the disease. The data do not support the iron deficiency hypothesis. Most probably, vitamin C deficiency was responsible for the difference between diseased and morphologically healthy individuals. A combination of protein and elemental analysis of excavated bones should thus be suitable for the detection of deficient hydroxylation and its etiology: iron or vitamin C deficiency.

A 51-year-old male patient presented with right-sided swelling of the neck and a 2-year history of decreasing olfaction that had culminated in complete anosmia. CT and MRI showed a calcified ethmoid tumor and destruction of the lamina cribrosa extending into the anterior fossa and frontal lobes. Contrast material demonstrated marked enhancement on the CT and MRI. Bilateral angiography of the external and internal carotid arteries failed to show tumor vascularity typical for an esthesioneuroblastoma but rendered an olfactory meningioma unlikely. Histological findings of cervical lymph nodes removed during neck dissection showed infiltration by an esthesioneuroblastoma (Kadish C classification). Tumor calcifications in these neoplasms are generally well seen on CT and--while not specific--may suggest the diagnosis. CT and MRI are the most sensitive methods of demonstrating local tumor growth, metastasis and bone destruction.

A total of 57 children aged between 5 and 15 years underwent endoscopic ethmoid surgery for recurrent acute or chronic rhinogenic sinusitis, chronic sinusitis associated with bronchial asthma or chronic bronchitis, early rhinogenous orbital complications and paranasal sinus disease associated with mucoviscidosis. The indications for surgical intervention are based on symptoms, the findings on nasal endoscopy and a CT scan of the paranasal sinuses in the coronal plane. The preoperative examination shows that in childhood there are endoscopically detectable anatomical variations of the ethmoid bone (pneumatised middle nasal concha, reversed curvature of the middle turbinate and contact between the uncinate process and the turbinate) that create the conditions for the development of inflammatory paranasal sinus diseases. Careful elimination of these obstructions can accomplish complete cure of the inflammation, and early orbital complications can be treated effectively by combination of surgery with infusion of antibiotics. All surgery was performed under endotracheal anaesthesia using the endoscopic technique described by Messerklinger. The follow-up period was between 6 and 18 months. With the exception of children suffering from mucoviscidosis, cure of the paranasal sinus disease and rhinomanometrically demonstrable improvement of the nasal breathing was achieved in all cases. On the basis of our results a conservative endoscopic approach is recommended as an effective surgical method for the treatment of paranasal sinus disease in childhood.

We report three patients with metastases to the ENT-region mimicking a primary malignant tumour. A 36-year-old woman presented with vertigo, sudden hearing loss, partial facial palsy and headaches. CT scan suggested a meningioma or an acoustic neuroma. Histological examination of the neoplasm removed surgically showed a metastasis from an amelanotic melanoma. A 38-year-old woman with nodules in the tongue had dysphagia. The history revealed that she had been treated successfully with chemotherapy for a carcinoma of the uterine cervix one year ago. Histological examination of a tongue biopsy showed a metastasis from the uterine carcinoma. The primary tumour was in complete remission. The third patient was treated for recurrent epistaxis. Physical examination showed a tumour in the right nasal cavity. A CT scan showed a tumour of the ethmoid cells and of the maxillary sinus, protruding into the nose. Histology and immunohistology proved a metastasis from a primary carcinoma of the liver. Ultrasound and CT scan of the liver confirmed the diagnosis.

A 82-year old woman patient was first diagnosed to have a dacryocystitis and was treated at the Department of Ophthalmology. Clinical examination and x-ray of the paranasal sinuses including tomographs led to the suspicion of a malignant, infiltratively growing tumour in the region of the left cheek and of the left ethmoidal cells. After endonasal removal of the tumour that obstructed the left nasal cavity and ethmoidal cells, histological diagnosis revealed an eosinophilic adenoma. Dacryocystitis had been caused secondarily by the impairment of lacrymal flow. Now, one year later, the patient is free from any recurrence and clinical or subjective signs and symptoms.

The so-called frontal recess (recessus frontalis) is a variable developed space of the anterior air cells, which is usually called "ductus" or "canalis naso-frontalis". As it leads into the frontal sinus, the state of the frontal sinus is entirely dependent on the conditions within the frontal recess. Its anatomical situation and transport of the secretion are described. The frontal recess may be influenced by narrow passes of the middle nasal meatus. All these facts are discussed in normal or abnormal states of nasal function. The clinical signs and sequelae of a diseased frontal recess are reported. For exact diagnosis nasal endoscopy, especially of the middle meatus, is recommended, apart from x-ray tomography or other clinical investigations. The various endoscopic findings are demonstrated. Finally, the indications are given for endoscopic operations, suggestions for endoscopic possibilities, and a detailed description of the technical procedure.

Because of its special anatomic features, the roof of the anterior ethmoid is a preferred area for frontobasal fractures as well as an area of hazard during ethmoid surgery. As clinical experience proves, the most critical area for lesions to occur is the vicinity of the anterior ethmoidal artery, especially where this leaves the dome of the ethmoid medially to reach the ethmoidal sulcus in the olfactory fossa. Complete ethmoidal specimen were investigated by the means of serial histological sections in the frontal plane. 40 anterior ethmoidal arteries were anatomically prepared and the special features of their topography like connection with the dura, fixation of the dura to the bone of the skull base and the variations of the thickness of the surrounding bony wall studied with regard to their surgical relevance. Not the dome of the ethmoidal roof proves to be the most critical point for lesions to occur, but the area where the anterior ethmoidal artery leaves the ethmoid medially, to enter the olfactory fossa. Here, the bone is tenfold thinner than at the very roof of the ethmoid.

In the second part of this paper the findings of electron microscopical studies on ultrastructural changes of the cilia of the ethmoidal mucous membrane in patients with mycotic chronic sinusitis are presented. Many pathological variations of the normal 9 + 2 pattern can be demonstrated, along with compound cilia and central axis deviation beyond 25 degrees. This together with the endoscopical and lightmicroscopical findings results in conditions which are different from those in acute sinusitis. It may as well explain, why hardly a conservative therapy--aiming mostly for vasoconstriction and decrease of mucosal edema--is successful in chronic sinusitis. Endoscopical surgery of the diseased anterior ethmoid in most of the cases brings along cure of the dependent frontal and maxillary sinuses as well.

Converse is using the term "interorbital space" for the ethmoid bone, especially its lateral wall. We added the frontal process of the upper jaw including spongy substance ("trajector"). Pathophysiology and clinical points of view of comminuted fractures are demonstrated.