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Your search keyword '"Ethionine pharmacology"' showing total 23 results
Start Over Descriptor "Ethionine pharmacology" Language german
23 results on '"Ethionine pharmacology"'

1. [The role of cysteine in cadmium- induced experimental testicular damage (author's transl)].

Author

Bordás E, Gabor S, and Papilian VV

Subjects
Animals, Cadmium antagonists & inhibitors, Cysteine metabolism, Ethionine pharmacology, Male, Rats, Sulfhydryl Reagents, Testis pathology, Cadmium Poisoning metabolism, Cadmium Poisoning pathology, Cysteine pharmacology, Testis drug effects
Abstract

Simultaneous administration of cysteine and DL-ethionine in food protects, and enhances, respectively, the tissue damage produced by parenteral administration of cadmium (CdCl2) in testicles of rats. The effects are explained as an inactivation of SH-groups by cadmium, and in interference in cysteine metabolism by ethionine, respectively.

Published
1976

2. [Further developments in pancreatic islet transplantation I. Induction of selective morphological changes in the exocrine pancreas].

Author

Huber W, Kolb E, Uhlschmid GK, Baumgartner D, and Largiadèr F

Subjects
Animals, Cell Separation, Ceruletide pharmacology, Ethionine pharmacology, Female, Male, Pancreas anatomy & histology, Rats, Islets of Langerhans Transplantation, Pancreas drug effects, Selenium pharmacology, Selenomethionine pharmacology
Abstract

For pancreatic islet transplantation to become clinically applicable, chemical agents are needed which cause selective morphological alterations in the exocrine part of the organ within a few hours after application. DL-ethionine (Aet), cerulein (Cd), seleno-DL-methionine (SeMet) and seleno-DL-ethionine (SeAet) were given to rats during various time periods. At 4 h after i.p. injection, 40 mg/kg SeMet caused the greatest selective morphological alterations in the exocrine pancreas. Acinar structure disappeared, the exocrine cells were abnormal and their nuclei had various dimensions and forms. There were, however, no alterations in the islet cells. At this time, neither Aet, Cd, nor SeAet produced similar changes. SeMet was the most toxic substance and was taken up in the shortest time and in the greatest amount. This selective destructive SeMet effect allows better isolation of the islets from exocrine tissue thereby increasing islet yield and decreasing transplantation volume. Better islet purification may prevent an early rejection.

Published
1985
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3. [Activity of parotid isoamylases in the ethionine-treated rat (author's transl)].

Author

Arglebe C, Einrauch HD, and Chilla R

Subjects
Animals, Female, Methionine deficiency, Rats, Time Factors, Ethionine pharmacology, Glycoside Hydrolases metabolism, Isoamylase metabolism, Parotid Gland enzymology
Abstract

In order to investigate the effects of ethionine (an antagonist of the essential amino acid, methionine) on the enzyme synthesis in the rat-parotid gland, rats were fed methionine-deficient diet and treated with DL-ethionine for 4 and 10 days. Compared with the controls, not only the synthesis but also the secretion of parotid isoamylases was impaired by ethionine. Acinar isoamylase activities dropped initially but increased distinctly after 10 days of ethionine treatment, possibly due to intra- as well as extracellular impairment of acinar protein secretion. After another 10 days during which no ethionine was given, the described changes were no longer observed.

Published
1978

5. [Inhibition by ethionine of Soman-induced enzyme biosynthesis in rat liver].

Author

Domschke W, Domagk GF, Domschke S, and Erdmann WD

Subjects
Animals, Cholinesterase Inhibitors toxicity, Cholinesterases blood, Isoflurophate toxicity, Liver drug effects, Male, Organophosphonates toxicity, Rats, Cholinesterase Inhibitors antagonists & inhibitors, Cholinesterases biosynthesis, Enzyme Induction drug effects, Ethionine pharmacology, Liver enzymology, Organophosphonates antagonists & inhibitors, Tryptophan Oxygenase biosynthesis
Published
1970

6. [Morphogenesis of the costs of Ochromonas malhamensis].

Author

Schnepf E and Kramer D

Subjects
Caffeine pharmacology, Cellulose analysis, Chloral Hydrate pharmacology, Ethionine pharmacology, Microscopy, Electron, Morphogenesis, Phenylalanine pharmacology, Protein Biosynthesis, Cell Wall analysis, Eukaryota growth & development
Published
1969
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7. [Experimental animal studies on the modification of iron absorption by exogenous pancreatin].

Author

Tönz O, Bretscher D, Liechti-Salzmann S, Donath A, and Wiesmann U

Subjects
Animals, Body Weight drug effects, Depression, Chemical, Hematocrit, Intestinal Absorption, Iron analysis, Iron blood, Iron Isotopes, Liver analysis, Male, Protein Binding drug effects, Rats, Transferrin analysis, Citrates metabolism, Ethionine pharmacology, Hemoglobins metabolism, Iron metabolism, Liver metabolism, Pancreatic Extracts pharmacology
Published
1971

9. [On the activation of dopa decarboxylase and other cytoplasmic liver enzymes by inducers of microsomal enzymes].

Author

Palm D, Ernzerhoff C, and Holtz P

Subjects
Animals, Carboxy-Lyases metabolism, Dactinomycin pharmacology, Ethionine pharmacology, L-Lactate Dehydrogenase metabolism, Liver cytology, Liver drug effects, Monoamine Oxidase metabolism, Phenobarbital antagonists & inhibitors, Proadifen pharmacology, Rats, Stimulation, Chemical, Tolbutamide pharmacology, Dopa Decarboxylase metabolism, Enzyme Induction, Hexachlorocyclohexane pharmacology, Liver enzymology, Microsomes enzymology, Phenobarbital pharmacology
Published
1967

11. [Action of puromycin, actinomycin D and ethionine on carbohydrate metabolism in the liver of rats fed with thyroid powder].

Author

Bargoni N, Grillo MA, Rinaudo MT, Bruno R, and Giunta C

Subjects
Animals, Depression, Chemical, Liver drug effects, Liver metabolism, Male, Mitochondria, Liver enzymology, Rats, Antithyroid Agents, Dactinomycin pharmacology, Ethionine pharmacology, Glucosephosphate Dehydrogenase metabolism, Glucosyltransferases metabolism, Glycolysis drug effects, Hydro-Lyases metabolism, Isomerases metabolism, L-Lactate Dehydrogenase metabolism, Ligases metabolism, Liver enzymology, Malate Dehydrogenase metabolism, Phosphofructokinase-1 metabolism, Phosphoglucomutase metabolism, Phosphogluconate Dehydrogenase metabolism, Puromycin pharmacology, Transferases metabolism
Published
1969
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13. [Studies on the effect of ascorbic acid on the activity and biosynthesis of mixed function oxygenases, as well as the concentration of hemoproteins in the microsome fraction of guinea pig liver].

Author

Leber HW, Degkwitz E, and Staudinger H

Subjects
Animals, Ethionine pharmacology, Guinea Pigs, Liver cytology, Liver drug effects, Liver enzymology, Methylcholanthrene pharmacology, Microsomes drug effects, Oxygenases biosynthesis, Phenobarbital pharmacology, Scurvy metabolism, Stimulation, Chemical, Acetanilides metabolism, Aminopyrine metabolism, Ascorbic Acid pharmacology, Cytochromes metabolism, Liver metabolism, Microsomes metabolism, Oxygenases metabolism
Published
1969

14. [Differential induction of microsomal N- and p-hydroxylation of aniline and N-ethylamiline in rabbits].

Author

Lange G

Subjects
Animals, Chloramphenicol pharmacology, Dactinomycin pharmacology, Ethionine pharmacology, Female, Hydroxylamines pharmacology, Liver enzymology, Male, NADP metabolism, Phenols pharmacology, Rabbits, Anesthetics, Local pharmacology, Aniline Compounds metabolism, Enzyme Induction, Liver metabolism, Microsomes enzymology, Microsomes metabolism, Mixed Function Oxygenases metabolism, Phenobarbital pharmacology
Published
1967

17. [Completion of the induction of microsomal enzymes in the rabbit liver].

Author

Lange G

Subjects
Animals, Chloromercuribenzoates pharmacology, Cytochromes metabolism, Dactinomycin pharmacology, Depression, Chemical, Ethionine pharmacology, Ethylmaleimide pharmacology, Liver metabolism, Microsomes metabolism, Mixed Function Oxygenases antagonists & inhibitors, Phenanthrolines pharmacology, Quinolines pharmacology, Rabbits, Aniline Compounds metabolism, Enzyme Induction, Liver enzymology, Microsomes enzymology, Mixed Function Oxygenases biosynthesis, Phenobarbital pharmacology
Published
1967

20. [The intestinal paneth cell. Cytomorphology, ultrastructural pathology and function. An contribution on the lysozyme theory (author's transl)].

Author

Otto HF

Subjects
Animals, Appendicitis pathology, Biological Evolution, Cell Division, Colitis, Ulcerative pathology, Colonic Neoplasms pathology, Crohn Disease pathology, Ethionine pharmacology, Gastritis pathology, Germ-Free Life, Histocytochemistry, Humans, Intestinal Neoplasms pathology, Intestines drug effects, Intestines enzymology, Metaplasia, Microscopy, Electron, Muramidase metabolism, Peutz-Jeghers Syndrome pathology, Puromycin pharmacology, Rats, Stomach Neoplasms pathology, Stomach Ulcer pathology, Triparanol pharmacology, Whipple Disease pathology, Zinc pharmacology, Intestines cytology
Published
1973

22. [Cytological and cytochemical studies of changes in the small intestine epithelium in albino mice under continuous treatment with the antimetabolites riboazauracil and ethionine].

Author

Eisenhuth I and Geyer G

Subjects
Animals, Cell Nucleus drug effects, Epithelium drug effects, Histocytochemistry, Intestine, Small metabolism, Rabbits, Regeneration drug effects, Uracil analogs & derivatives, Uracil pharmacology, Antimetabolites pharmacology, Ethionine pharmacology, Intestine, Small drug effects, Triazines pharmacology
Published
1966

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