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Dogs with spontaneous Diabetes mellitus were checked at regular intervals for protein excretion in the urine. A large number of dogs developed a proteinuria, very marked in some cases, with excretion of primarily macroproteins.

After introducing into developmental aspects of "Dalmatian dog research" uric acid excretion is explained on the basis of new results by the loss of a specific transport system in liver cell membranes. Therefore, uricase which is present in normal activities is supplied only to a limited extent with uric acid for the transformation into the easily soluble allantoin. As indicated by feeding experiments, the plasma urate level is increased from about 32 mumol/l (no purine intake) up to 150-200 mumol/l at very high levels of purine intake. Thus, the influence of nutrition on plasma urate level is extraordinary. The diseases urate-urolithiasis and "bronze syndrome" associated with dalmatian urate metabolism are characterized in view of the typical pattern of the diseases and of the therapeutical and prophylactical measures to be taken.