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7. Systemische Therapie von prämenopausalen Patientinnen mit hormonrezeptorpositivem, HER2-negativem Brustkrebs in den Frühstadien – Kontroversen und Standards in der Krankenversorgung.

Author

Müller, Volkmar, Fasching, Peter A., Nabieva, Naiba, Fehm, Tanja N., Thill, Marc, Schmidt, Marcus, Kühn, Thorsten, Banys-Paluchowski, Maggie, Belleville, Erik, Juhasz-Böss, Ingolf, Untch, Michael, Kolberg, Hans-Christian, Harbeck, Nadia, Aktas, Bahriye, Stickeler, Elmar, Kreuzeder, Julia, Hartkopf, Andreas D., Janni, Wolfgang, and Ditsch, Nina

Published
2024
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9. Update Mammakarzinom 2023 Teil 2 – Brustkrebs in fortgeschrittenen Krankheitsstadien.

Author

Lux, Michael P., Hartkopf, Andreas D., Fehm, Tanja N., Welslau, Manfred, Müller, Volkmar, Schütz, Florian, Fasching, Peter A., Janni, Wolfgang, Witzel, Isabell, Thomssen, Christoph, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc, Tesch, Hans, Ditsch, Nina, Aktas, Bahriye, Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, and Wöckel, Achim

Published
2023
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10. Update Mammakarzinom 2023 Teil 3 – Expertenmeinungen zu Brustkrebs in frühen Krankheitsstadien.

Author

Kolberg, Hans-Christian, Hartkopf, Andreas D., Fehm, Tanja N., Welslau, Manfred, Müller, Volkmar, Schütz, Florian, Fasching, Peter A., Janni, Wolfgang, Witzel, Isabell, Thomssen, Christoph, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc, Tesch, Hans, Ditsch, Nina, Lux, Michael P., Aktas, Bahriye, Banys-Paluchowski, Maggie, and Kolberg-Liedtke, Cornelia

Published
2023
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11. Behandlung des frühen Mammakarzinoms – 18. Internationaler St.-Gallen-Konsens vor dem Hintergrund der aktuellen deutschen Therapieempfehlungen diskutiert.

Author

Untch, Michael, Banys-Paluchowski, Maggie, Brucker, Sara Y., Budach, Wilfried, Denkert, Carsten, Ditsch, Nina, Fasching, Peter A., Haidinger, Renate, Heil, Jörg, Jackisch, Christian, Janni, Wolfgang, Kolberg, Hans-Christian, Krug, David, Loibl, Sibylle, Lüftner, Diana, van Mackelenbergh, Marion, Radosa, Julia C., Reimer, Toralf, Welslau, Manfred, and Würstlein, Rachel

Published
2023
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12. Update Mammakarzinom 2022 Teil 6 : Brustkrebs in fortgeschrittenen Krankheitsstadien

Author

Lüftner, Diana, Lux, Michael P., Fehm, Tanja N., Welslau, Manfred, Müller, Volkmar, Schütz, Florian, Fasching, Peter A., Janni, Wolfgang, Thomssen, Christoph, Witzel, Isabell, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc, Ditsch, Nina, Aktas, Bahriye, Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Wöckel, Achim, Kolberg, Hans-Christian, Harbeck, Nadia, Stickeler, Elmar, Tesch, Hans, and Hartkopf, Andreas D.

Subjects
Medizin
Abstract

Large-scale study programs on CDK4/6 inhibitors, targeted therapies, and antibody-drug conjugates launched in recent years have yielded results from current studies which are now being published in journals and presented at international conferences. In this context, new results are available from the major CDK4/6 inhibitor studies. Also, an increasing amount of data is being published from large-scale genomic studies on efficacy and resistance mechanisms in patients treated with CDK4/6 inhibitors. These results now form the basis for further research plans to investigate combination therapies and treatment sequencing. Based on the latest published results, sacituzumab govitecan is now available as a second antibody-drug conjugate; this brings an advantage in terms of overall survival for patients with hormone receptor-positive (HRpos)/HER2-negative (HER2neg) breast cancer. In this review article, we summarize the latest developments and place them in context according to the current status of research.

Published
2023

13. Update Mammakarzinom 2022 Teil 5 : Brustkrebs in frühen Krankheitsstadien

Author

Fehm, Tanja N., Welslau, Manfred, Müller, Volkmar, Lüftner, Diana, Schütz, Florian, Fasching, Peter A., Janni, Wolfgang, Thomssen, Christoph, Witzel, Isabell, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc, Tesch, Hans, Ditsch, Nina, Lux, Michael P., Aktas, Bahriye, Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Hartkopf, Andreas D., Wöckel, Achim, Kolberg, Hans-Christian, Harbeck, Nadia, and Stickeler, Elmar

Subjects
Medizin
Abstract

The treatment of patients with early stage breast cancer has changed in recent years due to the introduction of pembrolizumab, olaparib, and abemaciclib. These and other drugs with the same class of active ingredient are currently in trial for various indications. This review article summarizes the latest results that have either been presented at major conferences such as the ESMO 2022 or published recently in international journals. This includes reports on newly discovered breast cancer genes, atezolizumab in neoadjuvant therapy in HER2-positive patients, long-term data from the APHINITY study, and on how preoperative peritumoral application of local anesthetics can influence the prognosis. We also present solid data on dynamic Ki-67 from the ADAPT studies.

Published
2023

14. AGO-Empfehlungen zur operativen Therapie des Mammakarzinoms: Update 2022.

Author

Banys-Paluchowski, Maggie, Thill, Marc, Kühn, Thorsten, Ditsch, Nina, Heil, Jörg, Wöckel, Achim, Fallenberg, Eva, Friedrich, Michael, Kümmel, Sherko, Müller, Volkmar, Janni, Wolfgang, Albert, Ute-Susann, Bauerfeind, Ingo, Blohmer, Jens-Uwe, Budach, Wilfried, Dall, Peter, Fasching, Peter, Fehm, Tanja, Gluz, Oleg, and Harbeck, Nadia

Published
2023
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15. Update Mammakarzinom 2022 Teil 4 – Brustkrebs in fortgeschrittenen Krankheitsstadien.

Author

Aktas, Bahriye, Fehm, Tanja N., Welslau, Manfred, Müller, Volkmar, Lüftner, Diana, Schütz, Florian, Fasching, Peter A., Janni, Wolfgang, Thomssen, Christoph, Witzel, Isabell, Belleville, Erik, Untch, Michael, Thill, Marc, Tesch, Hans, Ditsch, Nina, Lux, Michael P., Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Hartkopf, Andreas D., and Wöckel, Achim

Published
2023
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17. Update Breast Cancer 2022 Part 4 - Advanced-Stage Breast Cancer

Author

Aktas, Bahriye, Fehm, Tanja N., Welslau, Manfred, Müller, Volkmar, Lüftner, Diana, Schütz, Florian, Fasching, Peter A., Janni, Wolfgang, Thomssen, Christoph, Witzel, Isabell, Belleville, Erik, Untch, Michael, Thill, Marc, Tesch, Hans, Ditsch, Nina, Lux, Michael P., Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Hartkopf, Andreas D., Wöckel, Achim, Kolberg, Hans-Christian, Stickeler, Elmar, Harbeck, Nadia, and Schneeweiss, Andreas

Subjects
Medizin
Abstract

For the treatment of patients with advanced HER2-negative hormone receptor-positive breast cancer, several substances have been introduced into practice in recent years. In addition, other drugs are under development. A number of studies have been published over the past year which have shown either an advantage for progression-free survival or for overall survival. This review summarizes the latest results, which have been published at current congresses or in specialist journals, and classifies them in the clinical treatment context. In particular, the importance of therapy with CDK4/6 inhibitors - trastuzumab deruxtecan, sacituzumab govitecan and capivasertib - is discussed. For trastuzumab deruxtecan, an overall survival benefit in HER2-negative breast cancer with low HER2 expression (HER2-low expression) was reported in the Destiny-Breast-04 study. Similarly, there was an overall survival benefit in the FAKTION study with capivasertib. The lack of overall survival benefit for palbociclib in the first line of therapy raises the question of clinical classification.

Published
2022

19. Update Mammakarzinom 2022 Teil 3 – Brustkrebs in frühen Krankheitsstadien.

Author

Fehm, Tanja N., Welslau, Manfred, Müller, Volkmar, Lüftner, Diana, Schütz, Florian, Fasching, Peter A., Janni, Wolfgang, Thomssen, Christoph, Witzel, Isabell, Belleville, Erik, Untch, Michael, Thill, Marc, Tesch, Hans, Ditsch, Nina, Lux, Michael P., Aktas, Bahriye, Banys-Paluchowski, Maggie, Schneeweiss, Andreas, Kolberg-Liedtke, Cornelia, and Hartkopf, Andreas D.

Published
2022
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21. Update Mammakarzinom 2022 Teil 1 – Brustkrebs in frühen Krankheitsstadien.

Author

Welslau, Manfred, Müller, Volkmar, Lüftner, Diana, Schütz, Florian, Stickeler, Elmar, Fasching, Peter A., Janni, Wolfgang, Thomssen, Christoph, Witzel, Isabell, Fehm, Tanja N., Belleville, Erik, Bader, Simon, Seitz, Katharina, Untch, Michael, Thill, Marc, Tesch, Hans, Ditsch, Nina, Lux, Michael P., Aktas, Bahriye, and Banys-Paluchowski, Maggie

Published
2022
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23. Update Mammakarzinom 2021 Teil 5 – fortgeschrittenes Mammakarzinom.

Author

Lüftner, Diana, Schütz, Florian, Stickeler, Elmar, Fasching, Peter A., Janni, Wolfgang, Kolberg-Liedtke, Cornelia, Kolberg, Hans-Christian, Thomssen, Christoph, Müller, Volkmar, Fehm, Tanja N., Belleville, Erik, Bader, Simon, Untch, Michael, Welslau, Manfred, Thill, Marc, Tesch, Hans, Ditsch, Nina, Lux, Michael P., Wöckel, Achim, and Aktas, Bahriye

Published
2022
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24. Update Mammakarzinom 2021 Teil 4 – Prävention und frühe Krankheitsstadien.

Author

Thomssen, Christoph, Fehm, Tanja N., Stickeler, Elmar, Fasching, Peter A., Janni, Wolfgang, Kolberg-Liedtke, Cornelia, Kolberg, Hans-Christian, Lüftner, Diana, Müller, Volkmar, Schütz, Florian, Belleville, Erik, Bader, Simon, Untch, Michael, Welslau, Manfred, Thill, Marc, Hartkopf, Andreas D., Tesch, Hans, Ditsch, Nina, Lux, Michael P., and Wöckel, Achim

Published
2022
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26. Update Mammakarzinom 2021 Teil 2 – fortgeschrittene Stadien, Langzeitfolgen und Biomarker.

Author

Ditsch, Nina, Stickeler, Elmar, Behrens, Annika, Belleville, Erik, Fasching, Peter A., Fehm, Tanja N., Hartkopf, Andreas D., Jackisch, Christian, Janni, Wolfgang, Kolberg-Liedtke, Cornelia, Kolberg, Hans-Christian, Lüftner, Diana, Lux, Michael P., Müller, Volkmar, Schneeweiss, Andreas, Schütz, Florian, Schulmeyer, Carla E., Tesch, Hans, Thomssen, Christoph, and Uleer, Christoph

Published
2022
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27. Update Mammakarzinom 2021 Teil 1 – Prävention und frühe Krankheitsstadien.

Author

Stickeler, Elmar, Aktas, Bahriye, Behrens, Annika, Belleville, Erik, Ditsch, Nina, Fasching, Peter A., Fehm, Tanja N., Hartkopf, Andreas D., Jackisch, Christian, Janni, Wolfgang, Kolberg-Liedtke, Cornelia, Kolberg, Hans-Christian, Lüftner, Diana, Lux, Michael P., Müller, Volkmar, Schneeweiss, Andreas, Schütz, Florian, Schulmeyer, Carla E., Tesch, Hans, and Thomssen, Christoph

Published
2021
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28. Update Mammakarzinom 2020 Teil 5 – Einführung von Substanzen aus der metastasierten Therapiesituation in die frühe Therapiesituation.

Author

Lux, Michael P., Schneeweiss, Andreas, Hartkopf, Andreas D., Müller, Volkmar, Janni, Wolfgang, Belleville, Erik, Stickeler, Elmar, Thill, Marc, Fasching, Peter A., Kolberg, Hans Christian, Untch, Michael, Harbeck, Nadia, Wöckel, Achim, Thomssen, Christoph, Schulmeyer, Carla E., Welslau, Manfred, Overkamp, Friedrich, Schütz, Florian, Lüftner, Diana, and Ditsch, Nina

Published
2021
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30. Vorwort

Author

Aktas, Bahriye, Banys-Paluchowski, Maggie, and Ditsch, Nina

Published
2024
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33. Einsatz eines gewebeähnlichen 3D in vitro Tumormodells (Sphäroid-Mikrotumor-Modell) zur Therapieoptimierung bei HER2/neu-negativen Brustkrebspatientinnen

Author

Funke, Ilona, Ditsch, Nina, Halfter, Kathrin, Von Dehn-Rotfelser, Karin, Hoffmann, Oliver, and Mayer, Barbara

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Zielsetzung: Patientinnen mit einem Her2/neu-positiven Karzinom profitieren von einer zielgerichteten Trastuzumabbehandlung. Dagegen haben Patientinnen mit einem Her2/neu-negativen Status trotz einer Vielzahl an Chemotherapie-Optionen eine ungünstige Prognose. Um bei diesen Patientinnen[for full text, please go to the a.m. URL], 45. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 19. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC), 52. Jahrestagung der Österreichischen Gesellschaft für Plastische, Ästhetische und Rekonstruktive Chirurgie (ÖGPRÄC)

Published
2014

35. Konsensusempfehlung des Deutschen Konsortiums Familiärer Brust- und Eierstockkrebs zum Umgang mit Ergebnissen der Multigenanalyse.

Author

Waha, Anke, Versmold, Beatrix, Kast, Karin, Kiechle, Marion, Ditsch, Nina, Meindl, Alfons, Niederacher, Dieter, Hahnen, Eric, Arnold, Norbert, Mundhenke, Christoph, Horvath, Judit, Auber, Bernd, Dikow, Nicola, Hauke, Jan, Wappenschmidt, Barbara, Riess, Olaf, Schott, Sarah, Speiser, Dorothee, Faust, Ulrike, and Sutter, Christian

Published
2018
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38. Konsensusempfehlung des Deutschen Konsortiums Familiärer Brust- und Eierstockkrebs zum Umgang mit Ergebnissen der Multigenanalyse.

Author

Waha, Anke, Versmold, Beatrix, Kast, Karin, Kiechle, Marion, Ditsch, Nina, Meindl, Alfons, Niederacher, Dieter, Hahnen, Eric, Arnold, Norbert, Mundhenke, Christoph, Horvath, Judit, Auber, Bernd, Dikow, Nicola, Hauke, Jan, Wappenschmidt, Barbara, Riess, Olaf, Schott, Sarah, Speiser, Dorothee, Faust, Ulrike, and Sutter, Christian

Published
2017
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40. [Breast cancer in male].

Author

Würstlein R, Hesse A, König A, Schulte-Vorwick F, Schrodi S, Ditsch N, Mahner S, and Harbeck N

Subjects
Aged, BRCA1 Protein genetics, BRCA2 Protein genetics, Breast Neoplasms, Male epidemiology, Breast Neoplasms, Male genetics, Breast Neoplasms, Male therapy, Early Detection of Cancer, Germany, Humans, Incidence, Male, Mastectomy, Middle Aged, Prognosis, Quality of Life, Risk Factors, Survival Rate, Breast, Breast Neoplasms, Male diagnosis, Palpation
Published
2017
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