1. Surface Modification of Biomaterials for Conjugation with Human Fetal Osteoblasts
- Author
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Françoise Borcard, Phally Kong, Céline Journot, Davide Staedler, Philip N. Sturzenegger, Franziska Krauss Juillerat, Urs T. Gonzenbach, Lucienne Juillerat-Jeanneret, and Sandrine Gerber-Lemaire
- Subjects
Cell adhesions ,Copper-free click reaction ,Functionalized biomaterials ,Human fetal osteoblasts ,Chemistry ,QD1-999 - Abstract
Surface functionalization of hydroxyapatite (HA) and ?-tricalcium phosphate (TCP) bioceramics with chemical ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible copper-free click reaction with azido-modified human fetal osteoblasts resulted in improved cell binding to both HA and TCP bioceramics, opening the way for using this methodology in the preparation of cell-engineered bone implants.
- Published
- 2013
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