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Der M. biceps brachii hat aufgrund der Beuge- und Supinationsfunktion am Arm funktionell eine große Bedeutung. Die vollständige Ruptur der distalen Bizepssehne wird typischerweise bei funktionsaktiven Männern gesehen. Der Kraftverlust nach konservativer Therapie ist ausgeprägt (30-40 % für die Flexion, >50 % für die Supination). Durch die Refixierung der Sehne an der Tuberositas radii kann ein gutes funktionelles Ergebnis in Aussicht gestellt werden. Chronische Teilläsionen der distalen Bizepssehne sind schmerzhaft und sollten in die Differenzialdiagnose von Ellenbogenschmerzen einbezogen werden [ABSTRACT FROM AUTHOR]

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Abstract Background Over the past years, reports have indicated that honey bee populations are declining and that infestation by an ecto-parasitic mite (Varroa destructor) is one of the main causes. Selective breeding of resistant bees can help to prevent losses due to the parasite, but it requires that a robust breeding program and genetic evaluation are implemented. Genomic selection has emerged as an important tool in animal breeding programs and simulation studies have shown that it yields more accurate breeding value estimates, higher genetic gain and low rates of inbreeding. Since genomic selection relies on marker data, simulations conducted on a genomic dataset are a pre-requisite before selection can be implemented. Although genomic datasets have been simulated in other species undergoing genetic evaluation, simulation of a genomic dataset specific to the honey bee is required since this species has a distinct genetic and reproductive biology. Our software program was aimed at constructing a base population by simulating a random mating honey bee population. A forward-time population simulation approach was applied since it allows modeling of genetic characteristics and reproductive behavior specific to the honey bee. Results Our software program yielded a genomic dataset for a base population in linkage disequilibrium. In addition, information was obtained on (1) the position of markers on each chromosome, (2) allele frequency, (3) χ2 statistics for Hardy-Weinberg equilibrium, (4) a sorted list of markers with a minor allele frequency less than or equal to the input value, (5) average r2 values of linkage disequilibrium between all simulated marker loci pair for all generations and (6) average r2 value of linkage disequilibrium in the last generation for selected markers with the highest minor allele frequency. Conclusion We developed a software program that takes into account the genetic and reproductive biology specific to the honey bee and that can be used to constitute a genomic dataset compatible with the simulation studies necessary to optimize breeding programs. The source code together with an instruction file is freely accessible at http://msproteomics.org/Research/Misc/honeybeepopulationsimulator.html

Background: Primary total knee arthroplasty following complex knee joint trauma is only performed occasionally. In most cases a reconstruction is carried out., Objective: Are there confirmed indications for primary total knee arthroplasty following trauma? Which special features should be paid attention to?, Material and Methods: A selective literature search was carried out. The spectrum of indications and recommendations for action for primary total knee arthroplasty following trauma are presented, particularly against the background of demographic changes., Results: The spectrum of indications for primary total knee arthroplasty following trauma is limited. This has so far been carried out only in centers with the appropriate equipment and expertise, also for the management of complications but despite good overall results is still carried out only rarely. There is a lack of studies with large patient collectives., Conclusion: Primary total knee arthroplasty following trauma is a safe procedure within the range of indications. The standard procedure for the vast majority of cases of complex knee trauma is a reconstruction., (© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)

Background: In this paper we present our first experience in the application of a new, fixed-angle plate fixation: the locking attachment plate (LAP, Synthes, Oberdorf, Switzerland). We examined whether the LAP is a useful addition to the existing technical palette for periprosthetic fractures. The LAP is used for periprosthetic fractures with stable prostheses or intramedullary implants. The plate can be installed, e.g., on a 4.5 mm locking compression plate (LCP). Locking screws or cortical screws can be placed through its 4 diagonal fixed-angle arms, bicortical around the prosthesis stem into the bone. The LAP is designed to prevent lateral screw pull-out, to stabilise the prosthesis stem and thus to allow early postoperative mobilisation of patients., Patients and Methods: We implanted the LAP by operative fracture-treatment in the ORIF technique in 17 patients with periprosthetic fractures of the femur, tibia and humerus. The follow-up was at least 13 months., Results: There were two losses to follow-up: the patients died a few weeks postoperatively. There was a total of two of 17 cases with infection events (11.8 %). We could examine 15 patients for follow-up. Eleven of these 15 patients regained their original range of motion (ROM) and nine of 15 patients their pretraumatic mobility. In all cases with periprosthetic humeral fractures we detected muscular deficits. In five out of 15 cases (33.3 %) no radiological fracture healing could be observed. Nevertheless in 14 of 15 cases the implant was stable without signs of implant or prosthetic loosening. There was no case of material failure., Conclusion: Periprosthetic fractures are an increasingly common complication in old, often multi-morbid patients. A contemporary therapeutic intervention and early postoperative mobilisation contribute substantially to the success of treatment. The first results in the use of the LAP as a new implant option for periprosthetic fractures of the femur, tibia and humerus are promising. Further studies are necessary to show whether our overall good results are reproducible in larger groups of patients and whether the LAP can be given a firm position in the technical repertoire for treatment of periprosthetic fractures., (Georg Thieme Verlag KG Stuttgart · New York.)

In case of impaired consciousness, metabolic acidosis with wide anion gap and elevated lactate levels a metformin associated lactic acidosis should be considered in diabetic patients. Taking into account the contraindications to metformin, lactic acidosis is a rare complication, however - if it occurs - fatal in 50-80%. The outcome of the surviving patients is good, once the acute stage is outlived due to immediate hemofiltration.