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2 results on '"C, Ehlerding"'

1. [Granulopoiesis in chronic myeloproliferative disorders (CMPD): electron microscopy/morphometric investigations]

Author

R S, Fritsch, H, Maschek, C, Ehlerding, W, Widjaja, H, Choritz, and A, Georgii

Subjects
Adult, Male, Microscopy, Electron, Myeloproliferative Disorders, Heart Diseases, Bone Marrow, Humans, Female, Middle Aged, Hematopoietic Stem Cells, Aged, Granulocytes, Hematopoiesis
Abstract

This pilot study comprises quantitative ultrastructural investigations of the normal, non-leukemic granulopoiesis in the bone marrow of four patients suffering from heart diseases, compared with the granulopoiesis of four patients with different types of CMPD. By evaluation of the morphometric parameters it could be demonstrated that normal granulopoiesis is subject to a strong functional order of organelles in the course of maturation, aiming at the preparation of mitoses of immature cells and the production of functionally capable specific granules. Contrary to this, the studied cases of CMPD exhibited striking differences of morphometric parameters, which may be interpreted as functional deficiencies or defects of organelles involved in the production of specific granules, with the phenomenon of dissociation of nuclear and cytoplasmic maturation.

Published
1990

2. [Granulopoiesis in chronic myeloproliferative disorders (CMPD): electron microscopy/morphometric investigations].

Author

Fritsch RS, Maschek H, Ehlerding C, Widjaja W, Choritz H, and Georgii A

Subjects
Adult, Aged, Female, Granulocytes pathology, Heart Diseases pathology, Hematopoietic Stem Cells pathology, Humans, Male, Microscopy, Electron methods, Middle Aged, Bone Marrow pathology, Granulocytes ultrastructure, Hematopoiesis, Hematopoietic Stem Cells ultrastructure, Myeloproliferative Disorders pathology
Abstract

This pilot study comprises quantitative ultrastructural investigations of the normal, non-leukemic granulopoiesis in the bone marrow of four patients suffering from heart diseases, compared with the granulopoiesis of four patients with different types of CMPD. By evaluation of the morphometric parameters it could be demonstrated that normal granulopoiesis is subject to a strong functional order of organelles in the course of maturation, aiming at the preparation of mitoses of immature cells and the production of functionally capable specific granules. Contrary to this, the studied cases of CMPD exhibited striking differences of morphometric parameters, which may be interpreted as functional deficiencies or defects of organelles involved in the production of specific granules, with the phenomenon of dissociation of nuclear and cytoplasmic maturation.

Published
1990

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