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1. [Ultrastructure of the liver in patients with cholesterol stones receiving chenodesoxycholic acid (author's transl)].

Author

Jorge A, Milutin C, Gutierrez L, and Burgos M

Subjects
Cholelithiasis drug therapy, Endoplasmic Reticulum ultrastructure, Humans, Mitochondria, Liver ultrastructure, Chenodeoxycholic Acid therapeutic use, Cholelithiasis pathology, Liver ultrastructure
Abstract

The ultrastructure of the liver was investigated in 5 normal persons and 10 patients with cholesterol stones. In the patients numerous intramitochondrial crystals could be found; precipitated cholesterol-digitonin complexes were found as well in the canaliculi, the sinus and the pericanalicular areas. 5 patients received chenodesoxycholic acid (10 mg/kg/day); liver biopsies taken 3 and 6 months after start of treatment did not show any more the changes described above.

Published
1979

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