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82 results on '"Bruhn, C"'

24. [in process]

Author

Bruhn C

Subjects
Anilides therapeutic use, Hedgehog Proteins drug effects, Humans, Neoplasms, Basal Cell genetics, Neoplasms, Basal Cell therapy, Pyridines therapeutic use, Signal Transduction drug effects, Neoplasms, Basal Cell surgery
Published
2017

25. Pitolisant for the treatment of narcolepsy with or without cataplexy.

Author

Bruhn C

Subjects
Administration, Oral, Adult, Arousal drug effects, Attention drug effects, Contraindications, Dose-Response Relationship, Drug, Female, Histamine H3 Antagonists adverse effects, Histamine H3 Antagonists pharmacokinetics, Humans, Male, Narcolepsy blood, Piperidines adverse effects, Piperidines pharmacokinetics, Randomized Controlled Trials as Topic, Histamine H3 Antagonists therapeutic use, Narcolepsy drug therapy, Piperidines therapeutic use
Abstract

Since March 2016, a new treatment option for adult patients with narcolepsy – with or without cataplexy – has been granted marketing authorization in Europe. Pitolisant (Wakix®) is an inverse agonst at the histamine-3 (H3) receptor. In clinical studies, tests for measurement of wakefulness and attention, pitolisant showed significantly better results in comparison with placebo and similar results in comparison with modafinil. Pitolisant is well tolerated. Postmarketing analyses have to collect data about the long-term safety of pitolisant when used in a real-life setting.

Published
2016

26. [Allergy diagnosis not trivial].

Author

Bruhn C

Subjects
General Practice, Humans, Sensitivity and Specificity, Asthma diagnosis, Asthma etiology, Intradermal Tests, Respiratory Hypersensitivity diagnosis, Respiratory Hypersensitivity etiology, Skin Tests
Published
2016
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27. [Greater involvement is required].

Author

Bruhn C

Subjects
Germany, Humans, Immunization Schedule, Immunization, Secondary, Infant, Newborn, Infant, Premature, Diseases prevention & control, Pneumococcal Infections prevention & control, Pneumococcal Vaccines administration & dosage
Published
2016
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28. [Angiotensin-receptor- and neprilysin-inhibition: a new option against heart failure].

Author

Bruhn C

Subjects
Biphenyl Compounds, Chronic Disease, Drug Combinations, Hospitalization, Humans, Valsartan, Aminobutyrates therapeutic use, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Enzyme Inhibitors therapeutic use, Heart Failure drug therapy, Neprilysin antagonists & inhibitors, Tetrazoles therapeutic use
Abstract

The molecular combination of sacubitril and valsartan (Entresto) is a new drug for reducing the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. It is usually administered in conjunction with other heart failure therapies, instead of an ACE inhibitor or an angiotensin-receptor blocker (ARB). In studies, sacubitril/ valsartan was superior to enalapril in reducing the risks of death and hospitalization for heart failure. Possible side effects of sacubitril/valsartan are hypotension, angioedema, impaired renal function and elevation in serum potassium levels. The drug should not be used in times of pregnancy and breast feeding, in patients with servere hepatic impairment (Child-Pugh C) and in combination with aliskiren in patients with diabetes.

Published
2016

29. [Dulaglutide and liraglutide compared].

Author

Bruhn C

Subjects
Glucagon-Like Peptide 1 adverse effects, Glucagon-Like Peptide 1 therapeutic use, Glucagon-Like Peptides adverse effects, Glucagon-Like Peptides therapeutic use, Humans, Hypoglycemic Agents adverse effects, Immunoglobulin Fc Fragments adverse effects, Liraglutide, Recombinant Fusion Proteins adverse effects, Diabetes Mellitus, Type 2 drug therapy, Glucagon-Like Peptide 1 analogs & derivatives, Glucagon-Like Peptides analogs & derivatives, Hypoglycemic Agents therapeutic use, Immunoglobulin Fc Fragments therapeutic use, Recombinant Fusion Proteins therapeutic use
Published
2015

31. [Hyaluronidase addition brings benefits].

Author

Bruhn C

Subjects
Anesthesia, Local methods, Humans, Anesthetics, Local administration & dosage, Hyaluronoglucosaminidase administration & dosage, Ophthalmologic Surgical Procedures methods
Published
2015

32. [New galenics increased tacrolimus bioavailability].

Author

Bruhn C

Subjects
Biological Availability, Chemistry, Pharmaceutical, Excipients pharmacokinetics, Humans, Immunosuppressive Agents administration & dosage, Tacrolimus administration & dosage, Immunosuppressive Agents pharmacokinetics, Tacrolimus pharmacokinetics
Published
2015

33. [A chip instead of a pill: "Intelligent" drugs and diagnostic devices].

Author

Bruhn C

Subjects
Delayed-Action Preparations, Drug Monitoring instrumentation, Medication Adherence, Telemedicine, Artificial Intelligence, Cell Phone instrumentation, Drug Delivery Systems instrumentation, Lab-On-A-Chip Devices, Micro-Electrical-Mechanical Systems instrumentation, Therapy, Computer-Assisted instrumentation
Published
2014
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34. [Gene therapy - successes and many unsolved questions].

Author

Bruhn C

Subjects
Clinical Trials as Topic trends, Cooperative Behavior, Forecasting, Genes, Viral genetics, Genetic Vectors genetics, Genetic Vectors therapeutic use, Germany, Humans, Interdisciplinary Communication, Leber Congenital Amaurosis genetics, Leber Congenital Amaurosis therapy, Leukemia genetics, Leukemia therapy, Neoplasms genetics, Neoplasms therapy, Outcome and Process Assessment, Health Care, Gene Transfer Techniques trends, Genetic Therapy methods, Genetic Therapy trends
Published
2014
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35. [Influenza vaccination - low vaccination rates among healthcare professionals].

Author

Bruhn C

Subjects
Evidence-Based Medicine, Germany epidemiology, Humans, Occupational Diseases epidemiology, Occupational Diseases prevention & control, Prevalence, Risk Factors, Cross Infection epidemiology, Cross Infection prevention & control, Health Personnel statistics & numerical data, Influenza Vaccines therapeutic use, Influenza, Human epidemiology, Influenza, Human prevention & control, Mass Vaccination statistics & numerical data
Published
2014
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37. [Pregnancy during or after cancer].

Author

Bruhn C

Subjects
Adult, Cooperative Behavior, Cross-Sectional Studies, Disease Progression, Family Planning Services, Female, Humans, Infant, Newborn, Infertility, Female etiology, Infertility, Female prevention & control, Infertility, Male epidemiology, Infertility, Male etiology, Infertility, Male prevention & control, Interdisciplinary Communication, Male, Maternal Age, Pregnancy, Pregnancy Complications, Neoplastic epidemiology, Pregnancy Complications, Neoplastic therapy, Prenatal Diagnosis, Prognosis, Young Adult, Pregnancy Complications, Neoplastic diagnosis
Published
2014
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38. [The reward system of the brain: the brain loves surprises].

Author

Bruhn C

Subjects
Adult, Animals, Association Learning physiology, Brain Mapping, Child, Dopamine metabolism, Gambling, Habituation, Psychophysiologic physiology, Haplorhini, Humans, Magnetic Resonance Imaging, Motivation physiology, Nerve Net physiopathology, Neural Inhibition physiology, Nucleus Accumbens physiopathology, Oxygen blood, Parkinson Disease physiopathology, Positron-Emission Tomography, Prefrontal Cortex physiopathology, Rats, Reinforcement, Psychology, Ventral Tegmental Area physiopathology, Arousal physiology, Attention physiology, Brain physiopathology, Emotions physiology, Reward
Published
2014
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39. [Presenteeism: work despite illness].

Author

Bruhn C

Subjects
Burnout, Professional etiology, Burnout, Professional prevention & control, Cardiovascular Diseases etiology, Cardiovascular Diseases prevention & control, Communicable Disease Control, Germany, Humans, National Health Programs, Risk Factors, Absenteeism, Health Behavior, Health Status, Occupational Health trends, Sick Leave trends
Published
2014
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40. [Naming and packaging of pharmaceutical products].

Author

Bruhn C

Subjects
Germany, Drug Labeling legislation & jurisprudence, Drug Labeling trends, Drug Packaging legislation & jurisprudence, Drug Packaging trends, Legislation, Drug trends, Pharmaceutical Preparations classification, Terminology as Topic
Published
2013
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41. [The fight against counterfeit drugs].

Author

Bruhn C

Subjects
Europe, Legislation, Drug, Counterfeit Drugs, Drug Labeling legislation & jurisprudence, Drug Packaging legislation & jurisprudence, Fraud legislation & jurisprudence, Fraud prevention & control, Government Regulation, Product Surveillance, Postmarketing
Published
2013
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42. [Presenteeism: attending work while sick].

Author

Bruhn C

Subjects
Anxiety diagnosis, Anxiety epidemiology, Communicable Diseases transmission, Cross-Sectional Studies, Efficiency, Organizational statistics & numerical data, Germany, Humans, Illness Behavior, Occupational Diseases diagnosis, Occupational Diseases epidemiology, Physician Impairment psychology, Physician Impairment statistics & numerical data, Anxiety psychology, Career Mobility, Health Behavior, Occupational Diseases psychology, Sick Leave statistics & numerical data, Workload psychology, Workload statistics & numerical data
Published
2013
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43. [Patient blood management - fewer transfusions, lower costs].

Author

Bruhn C

Subjects
Anemia blood, Austria, Blood Loss, Surgical prevention & control, Cooperative Behavior, Cost Savings, Erythrocyte Volume, Erythropoietin administration & dosage, Erythropoietin economics, Ferric Compounds administration & dosage, Ferric Compounds economics, Hematinics administration & dosage, Hematinics economics, Hemoglobinometry, Hemostasis, Surgical economics, Hemostasis, Surgical methods, Humans, Interdisciplinary Communication, National Health Programs statistics & numerical data, Oxygen Inhalation Therapy economics, Oxygen Inhalation Therapy methods, Patient Care Team economics, Preoperative Care economics, Preoperative Care methods, Transfusion Reaction, Anemia economics, Anemia therapy, Blood Transfusion economics, Blood Transfusion statistics & numerical data, National Health Programs economics
Published
2013
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44. [Pain memory--can we forget chronic pain?].

Author

Bruhn C

Subjects
Catastrophization diagnosis, Catastrophization prevention & control, Catastrophization psychology, Chronic Pain psychology, Depression psychology, Humans, Chronic Pain diagnosis, Chronic Pain prevention & control, Depression diagnosis, Depression prevention & control, Memory, Pain Management trends, Pain Measurement trends
Published
2013
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45. [Pertuzumab. Dual strategy for the first-line treatment of metastatic HER2-positive breast cancer].

Author

Bruhn C

Subjects
Antibodies, Monoclonal, Humanized administration & dosage, Antibodies, Monoclonal, Humanized adverse effects, Antibodies, Monoclonal, Humanized pharmacokinetics, Breast Neoplasms pathology, Drug Interactions, Female, Humans, Neoplasm Metastasis drug therapy, Antibodies, Monoclonal, Humanized therapeutic use, Breast Neoplasms drug therapy, Breast Neoplasms genetics, Receptor, ErbB-2 genetics
Published
2013

46. [Electronic noses: how to "smell" diseases].

Author

Bruhn C

Subjects
Diagnosis, Differential, Equipment Design, Humans, Lung Diseases diagnosis, Lung Neoplasms diagnosis, Predictive Value of Tests, Breath Tests instrumentation, Electrodiagnosis instrumentation, Electronic Nose, Odorants
Published
2013
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47. [Supervised exercise programs for patients with peripheral arterial disease].

Author

Bruhn C

Subjects
Contraindications, Cooperative Behavior, Evidence-Based Medicine, Germany, Humans, Interdisciplinary Communication, Motivation, Patient Education as Topic, Physician's Role psychology, Practice Guidelines as Topic, Prescriptions, Rehabilitation Centers, Treatment Outcome, Exercise Therapy methods, Intermittent Claudication rehabilitation, Peripheral Arterial Disease rehabilitation, Walking
Published
2013
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49. [Supply shortages of drugs - a global problem].

Author

Bruhn C

Subjects
Antineoplastic Agents economics, Drug Industry economics, Drug Industry legislation & jurisprudence, Drug Substitution, Germany, Health Services Accessibility economics, Health Services Accessibility legislation & jurisprudence, Humans, United States, United States Food and Drug Administration legislation & jurisprudence, Antineoplastic Agents supply & distribution, Internationality
Published
2012

50. [Phototoxic drug reaction - the dark side of summer].

Author

Bruhn C

Subjects
Antipsychotic Agents adverse effects, Cortisone therapeutic use, Dermatitis, Photoallergic drug therapy, Dermatitis, Phototoxic drug therapy, Histamine Antagonists therapeutic use, Humans, Light, Plants, Medicinal adverse effects, Quinidine adverse effects, Risk Assessment, Dermatitis, Photoallergic etiology, Dermatitis, Phototoxic etiology, Photosensitizing Agents adverse effects, Seasons, Ultraviolet Rays adverse effects
Published
2012
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