This study aims to present an effort for an encounter between Christian faith and science in Alister E. McGrath’s thinking. The process of encountering both Christian faith and science is mediated by Christian natural theology. Christian natural theology is the result of rethinking conventional natural theology by McGrath. This is carried out because the meaning of conventional natural theology as an interface of Christian faith and science is not in accordance with Christian faith. The efforts to encounter Christian faith and science through conventional natural theology are something that is not possible, because conventional natural theology is denoted as pure theology centred on the rationality of scientific thought alone. In this article, we will show how Christian natural theology as a result of thinking by McGrath can be a medium for an encounter between Christian faith and science. The analysis of this article is generally based on the writings of McGrath, which are only partially reconciled with the views of several other theologies. Data collection was carried out through a literature study and described descriptively. The result of the research is a description of the encounter between Christian faith and science mediated by Christian natural theology. McGrath established Christian natural theology on observations in critical reality, Christian history and the word of God (Gn 1 and 2), allowing the human intellect to have a strong relationship with the order and beauty of nature that God created. This is the reason why the encounter between Christian faith and science based on McGrath’s concept of thought is more likely to reveal the truth in the reality of the Christian faith’s life. Intradisciplinary and/or interdisciplinary implications: This study recommends that efforts be made to identify faith, science and natural theology in the work of Alister E. McGrath. This article has contributed to highlighting natural theology, which is still under long discussion, especially in the context of the Christian faith and the ambiguity of nature, which is also important in various disciplines, including theology, natural science and science.