1. [Metabolic aspects of parsalmide in the cat (author's transl)].
- Author
-
Fleischmann L
- Subjects
- Animals, Arylsulfatases urine, Benzamides urine, Cats, Glucuronates urine, Glucuronidase urine, Species Specificity, Benzamides metabolism
- Abstract
2-Proparglyoxy-5-amino-N-(n-butyl)-benzamide(parsalmide, My 41-6) given s.c. to the cat and excreted in the urine, was present partly as unchanged parsalmide (25-62% of total excreted compounds), partly as unstably conjugated compounds (17-36%, mainly N-glucuronilparsalmide), and partly as stably conjugated compounds (11-36%, mainly N-acetylparsalmide). Urinary excretion of parsalmide and its metabolites continued for some days, indicating a slow excretion from the body, contrasting with other species, man included, previously examined. Summarizing, there are some 5-6 metabolites of parsalmide in the urine of treated cats, apart from unchanged parsalmide.
- Published
- 1980