1. [Presenile dementia in polycystic lipomembranous osteodysplasia].
- Author
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Schäfer C, Klünemann HH, Ibach B, Mueller J, Putzhammer A, Trender-Gerhard I, Schuierer G, and Klein HE
- Subjects
- Adult, Alzheimer Disease diagnosis, Alzheimer Disease psychology, Basal Ganglia pathology, Basal Ganglia Diseases diagnosis, Basal Ganglia Diseases psychology, Bone Cysts diagnosis, Bone Cysts psychology, Calcinosis diagnosis, Calcinosis psychology, Diagnosis, Differential, Electroencephalography, Female, Germany, Humans, Lipodystrophy diagnosis, Lipodystrophy psychology, Magnetic Resonance Imaging, Neurologic Examination, Neuropsychological Tests, Tomography, X-Ray Computed, Alzheimer Disease genetics, Basal Ganglia Diseases genetics, Bone Cysts genetics, Calcinosis genetics, Chromosome Aberrations, Genes, Recessive, Lipodystrophy genetics
- Abstract
We present a 36-year-old woman with a 3-year history of cognitive decline followed by development of a small stepped gait and urinary and fecal incontinence. Workup revealed multiple bone cysts documented by X-ray and idiopathic hyperprolactinoma. An MRI confirmed the CT finding of massive bilateral basal ganglia calcification. This is the first case of polycystic lipomembranous osteodysplasia described in Germany. We conclude that patients with presenile dementia, psychosis, or early-onset Parkinsonism associated with basal ganglia calcification should undergo X-rays of hand and feet to rule out polycystic lipomembranous osteodysplasia.
- Published
- 2002
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