12 results on '"Anemia, Refractory, with Excess of Blasts"'
Search Results
2. [Clarification of possible anemia]
- Author
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J, Uprichard and B J, Bain
- Subjects
Diagnosis, Differential ,Male ,Anemia, Refractory, with Excess of Blasts ,Bone Marrow ,Biopsy ,Myelodysplastic Syndromes ,Humans ,Anemia, Macrocytic ,Hemochromatosis ,Prognosis ,Referral and Consultation ,Aged ,Anemia, Sideroblastic - Published
- 2009
3. [Granulocytic sarcoma of the tonsils associated with myelodysplastic syndrome]
- Author
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M, Geisse, G, Mall, D, Fritze, and M, Gartenschläger
- Subjects
Male ,Anemia, Refractory, with Excess of Blasts ,Tuberculosis, Miliary ,Palatine Tonsil ,Tonsillar Neoplasms ,Peritonsillar Abscess ,Middle Aged ,Anemia, Sideroblastic ,Tonsillitis ,Bone Marrow ,Humans ,Sarcoma, Myeloid ,Tomography, X-Ray Computed ,Peroxidase - Abstract
A 60-year-old man with anaemia was found to have a myelodysplastic syndrome (MDS) which was classified as refractory anemia with ringsideroblasts (RAEB). Because of severe fever the patient was hospitalized. Waldeyer's throat ring revealed signs of acute inflammation.Indicated severe anemia and thrombocytopenia. Leucocytes were 8000/ml with a pathological shift to the left (1920/ml blasts). CRP (4.7 g/dl) and BSG (59/91mm) were abnormal. An axial CT of the neck showed a left sided paratonsillar abscess.The tonsillitis was treated with antibiotics. Persistent fever up to 39.8 degrees C suggested resistance to therapy. After three weeks the patient developed septicemia and died. Autopsy revealed MDS with excess of blasts in transformation (RAEBT-t). Granulocytic sarcoma was found in the throating where there was no paratonsillar abscess. Generalized miliary tuberculosis was proved at autopsy, explaining the continuous fever resistant to antibiotic treatment.Granulocytic sarcoma is rarely associated with myelodysplastic syndrome. Deficiency in the immune system may facilitate the occurrence of miliary tuberculosis.
- Published
- 2002
4. [Cervical tuberculous lymphadenopathy--a rare complication of myelodysplastic syndrome]
- Author
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S, Stoll, P, Itin, T, Bregenzer, M, Wernli, and M J, Bargetzi
- Subjects
Diagnosis, Differential ,Ovarian Neoplasms ,Anemia, Refractory, with Excess of Blasts ,Chemotherapy, Adjuvant ,Antineoplastic Combined Chemotherapy Protocols ,Cystadenocarcinoma, Papillary ,Humans ,Female ,Middle Aged ,Neoplasm Recurrence, Local ,Opportunistic Infections ,Tuberculosis, Lymph Node ,Neck - Abstract
Patients with myelodysplasia are susceptible to infections due to their compromised immunity. If presenting with a cervical lymphadenopathy patients must, in addition to other causes, be evaluated for tuberculosis, especially if they show a concurrent erythema nodosum.
- Published
- 2002
5. [Myelodysplastic syndromes (MDS). Aspects of hematopathologic diagnosis]
- Author
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A, Schmitt-Graeff, D, Mattern, H, Köhler, J, Hezel, and M, Lübbert
- Subjects
Adult ,Chromosome Aberrations ,Male ,Anemia, Refractory, with Excess of Blasts ,Bone Marrow ,Myelodysplastic Syndromes ,Y Chromosome ,Humans ,Female ,Chromosome Deletion ,Child ,Hematopoietic Stem Cells - Abstract
Myelodysplastic syndromes (MDS) are a heterogenous group of clonal stem cell disorders which generally occur in older adults but may also affect children. Primary MDS should be distinguished from secondary MDS associated with antineoplastic or immunosuppressive therapy (t-MDS), exposure to toxic compounds, or genetic disorders. The establishment of a neoplastic clone is reflected by dysplastic features and impaired function which may affect all three hematopoietic cell lineages. The ineffective hematopoiesis which causes bone marrow failure is accompanied by peripheral blood cytopenia and is considered to result from increased apoptosis, at least in the less advanced MDS stages. The elucidation of the molecular pathogenesis of MDS has provided evidence that chromosomal abnormalities are present in about 50% of patients with primary MDS. They include numerical aberrations such as monosomy 5 or 7, trisomy 8, loss of the Y-chromosome and structural abnormalities such as deletion of the long arm of chromosome 5 (5q-syndrome), 7, or 8. Based on the percentage of blasts (5%, 5-20%, 20-30%) and the presence of15% ringed sideroblasts for marrows with5% blasts, the French-American-British (FAB) classifies MDS into 4 morphologic categories: refractory anemia (RA), refractory anemia with excess of blasts (RAEB), refractory anemia with excess of blasts in transformation (RAEB-t), and refractory anemia with ringed sideroblasts. The fifth morphologic type is chronic myelomonocytic leukemia characterized by peripheral blood monocytosis (1x10(9)/l). However, a modification of this classification will be proposed by the World Health Organization, with the intention of lowering the threshold for the diagnosis of AML from 30% to 20% blast cells. In patients presenting with cytopenias suggesting impaired hematopoiesis, the initial diagnosis depends mainly on the cytological evaluation of bone marrow and blood smears and the histological findings of trephine bone marrow biopsy. In a retrospective analysis we evaluated the occurrence of the distinct FAB-categories as percentage of the total number of MDS cases diagnosed at the Institute of Pathology of the University of Freiburg. A total of 63% fullfilled the criteria of RA/RARS, 17% of RAEB, 14% of RAEB-t, and 6% of CMML. A fibrotic variant of MDS was observed in 7.67% of all cases, ranging from 2.34% in RA up to 15. 42-15.84% in the categories which did not show significant differences with regard to myelofibrosis. The histologic evaluation of a trephine bone marrow biopsy is of critical importance for the evaluation of fibrotic or hypocellular MDS since these patterns are not reflected by the cytological examination. The combined cytological and histological diagnosis of bone marrow and peripheral blood is a reliable tool for the initial diagnosis of MDS. In addition, cytogenetic and molecular analysis should be performed. Presently, the risk of leukemic transformation is evaluated using the International Prognostic Scoring System for MDS, which is the sum of the scores of bone marrow blasts, karyotypes and cytopenia. In the context of clinical trials therapeutic modalities should be considerd according to the age and the general performance state and the prognostic scores of individual patients.
- Published
- 2000
6. [The appearance of Sweet's syndrome during the transition from a myelodysplastic syndrome to erythroleukemia]
- Author
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S, Grüne, R, Panizzon, F, Egli, W, Siegenthaler, and P, Greminger
- Subjects
Male ,Anemia, Refractory, with Excess of Blasts ,Time Factors ,Lung Diseases, Fungal ,Candidiasis ,Middle Aged ,Combined Modality Therapy ,Sweet Syndrome ,Diagnosis, Differential ,Fatal Outcome ,Recurrence ,Aspergillosis ,Esophagitis ,Humans ,Leukemia, Erythroblastic, Acute - Abstract
Two months after being diagnosed as having refractory anaemia with an excess of blasts in transformation (RAEB-T), a 62-year-old man presented in the emergency room with fever (40 degrees C) for two weeks and scattered deep-red macular indolent efflorescences over the chest, back, face and thighs. Other than splenomegaly there were no significant findings on physical examination.Erythrocyte sedimentation rate was increased to 38 mm in the first hour. Haemoglobin concentration and platelet count were at the lower limits of normal, white cell count within the normal range. Differential count: 60 erythroblasts per 100 leukocytes and 33.5 blast cells. Two skin biopsies revealed massive oedema in the upper corium and focal erythrocyte extravasations. There were perivascular and perifollicular inflammatory infiltrates in the deeper layers and elastosis of the corium. There was no leukocytoclastic vasculitis. These findings established the diagnosis of Sweet syndrome and erythroleukaemia.The erythroleukaemia was treated symptomatically and the skin changes gradually receded under prednisone, 1 mg/kg, but new spots occurred when the prednisone dose was halved. Candida oesophagitis occurred as a complication of the erythroleukaemia. Chest radiogram showed diffuse infiltrates in both upper lobes of the lung. Despite intensive antimycotic and antibiotic treatment the patient died 10 days later from pulmonary aspergillosis.This case report describes the rare occurrence of Sweet syndrome during the transformation from a myelodysplastic Syndrome to erythroleukaemia.
- Published
- 1996
7. [Myelodysplastic diseases in childhood]
- Author
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C, Niemeyer, B, Stollmann-Gibbels, W, Ebell, G, Gaedicke, and U, Creutzig
- Subjects
Diagnosis, Differential ,Anemia, Refractory, with Excess of Blasts ,Karyotyping ,Myelodysplastic Syndromes ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Leukemia, Myelomonocytic, Chronic ,Child ,Combined Modality Therapy ,Bone Marrow Transplantation - Abstract
The myelodysplastic syndromes (MDS) are a group of hematopoietic neoplasms characterized by ineffective hematopoiesis and a high risk of transformation in acute leukemia. Pathogenesis and clinical course of these disorders are heterogenous. MDS is unusual in childhood, and differential diagnosis is specially broad in this age group. Allogenic bone marrow transplantation is the treatment of choice. Therapy with hematopoietic growth factors can overcome the maturation defect of the malignant clone in some instances. Multicenter studies are necessary to accumulate sufficient data on pathogenesis, clinical course and treatment results of MDS in childhood.
- Published
- 1992
8. [Unusual initial manifestation in a case of refractory anemia with excess of blasts]
- Author
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P, Beris, M, Soulier-Lauper, V, Parlier, and M, Jotterand-Bellomo
- Subjects
Chromosome Aberrations ,Male ,Anemia, Refractory, with Excess of Blasts ,Chromosomes, Human, Pair 11 ,Karyotyping ,Chromosomes, Human, Pair 5 ,Humans ,Chromosome Disorders ,Female ,Middle Aged ,Thrombocytopenia - Abstract
In 1987, a 50-year-old patient presented with isolated thrombocytopenia (27,000/mm3) which proved to be refractory to steroid medication and high i.v. doses of immunoglobulin. Two years later he developed macrocytic anemia. Chromosomal analysis confirmed the diagnosis of myelodysplastic syndrome (MDS), refractory anemia type with blast excess. Cytogenetically, three cellular populations were observed: one normal (75% of metaphases) and two abnormal, clone A (2%) 46,XY, del(5q), del(11q), and clone B (23%) 46,XY, del(5q), del(11q) plus 2 other anomalies. Evolution was characterized by worsening of the bicytopenia with marked hypoplasia of the megakaryocytic and erythroid series while the percentage of blasts remained stable. Concerning the chromosomal markers, the normal population disappeared and clone A became predominant (clone A 97%, clone B 3%). This case shows that isolated thrombocytopenia can be the sole initial manifestation of MDS. We discuss the possibility that "refractory thrombocytopenia" constitutes a diagnostic category like refractory anemia or refractory anemia with ring sideroblasts. The proliferative advantage of clone A or the disadvantage of clone B may be due to the occurrence of new, cytogenetically non-detectable mutations.
- Published
- 1991
9. [Patient with anemia, thrombopenia and slight leukocytosis]
- Author
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C, Clemm, M, Wick, R, Bartl, M, Goebel, and H J, Kolb
- Subjects
Diagnosis, Differential ,Leukemia, Myeloid, Acute ,Anemia, Refractory, with Excess of Blasts ,Leukemia ,Bone Marrow ,Leukocytosis ,Myelodysplastic Syndromes ,Biopsy, Needle ,Humans ,Female ,Middle Aged ,Thrombocytopenia ,Follow-Up Studies - Published
- 1990
10. [Combined GM-CSF and erythropoietin therapy in myelodysplastic syndrome]
- Author
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F, Egli, S, Hofer, P, Greminger, and K, Rhyner
- Subjects
Blood Platelets ,Male ,Anemia, Refractory, with Excess of Blasts ,Colony-Stimulating Factors ,Pancytopenia ,Stem Cells ,Granulocyte-Macrophage Colony-Stimulating Factor ,Humans ,Middle Aged ,Growth Substances ,Erythropoietin - Abstract
A 60-year-old patient with a myelodysplastic syndrome (MDS) corresponding to refractory anemia with an increase in blast cells (RAEB) was treated with granulocyte-macrophage colony stimulating factor (GM-CSF) and erythropoietin (EPO) for severe symptomatic pancytopenia. During the GM-CSF treatment a distinct increase in granulocytes was observed, but the reticulocytes and thrombocytes decreased to the point where treatment had to be discontinued after eight days. After subsequent treatment with EPO the reticulocyte count rose from 0% to 2%. However, this rise alone was insufficient to decrease the number of blood transfusions required. The thrombocyte count rose to the original values after the cessation of GM-CSF therapy while continuing treatment with EPO. Bone marrow investigations were performed before and after GM-CSF treatment and indicated a distinct increase in the myeloid precursor cells after therapy, without an increase in blasts. On the other hand, an obvious decrease in erythro- and megakaryopoiesis was observed.
- Published
- 1989
11. [Diagnosis in the myelodysplastic syndrome]
- Author
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W, Hunstein and A D, Ho
- Subjects
Anemia, Refractory, with Excess of Blasts ,Myelodysplastic Syndromes ,Anemia, Refractory ,Humans ,Anemia, Sideroblastic - Published
- 1987
12. [Treatment of myelodysplastic syndromes]
- Author
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C, Aul, A, Heyll, N, Gattermann, and W, Schneider
- Subjects
Diagnosis, Differential ,Male ,Anemia, Refractory, with Excess of Blasts ,Leukemia, Myeloid ,Myelodysplastic Syndromes ,Humans ,Preleukemia ,Bone Marrow Examination ,Female ,Middle Aged ,Prognosis ,Combined Modality Therapy ,Aged - Published
- 1987
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