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Your search keyword '"Androstadienes chemistry"' showing total 1 results
Start Over Descriptor "Androstadienes chemistry" Language german
1 results on '"Androstadienes chemistry"'

1. [Unexpected formation of an estrone derivative from androsta-1,4-diene-3,17-dione].

Author

Görlitzer K, Bonnekessel Ch, Jones PG, and Kaufmann G

Subjects
Androstadienes metabolism, Animals, Crystallography, X-Ray, Cytosol metabolism, Estrone metabolism, Female, In Vitro Techniques, Models, Molecular, Molecular Conformation, Rabbits, Receptors, Estrogen drug effects, Receptors, Estrogen metabolism, Uterus metabolism, Androstadienes chemistry, Estrone analogs & derivatives, Estrone chemical synthesis
Abstract

Reaction of androsta-1,4-diene-3,17-dione (1) with pyrrolidine and p-toluenesulfonic acid in toluene gives 3-pyrrolidino-estra-1,3,5(10)-triene-6,17-dione (7) in poor yield, whose structure is shown by X-ray analysis. Compared with 3H-estradiol, compound 7 shows only a weak receptor binding activity tested in an in vitro screening using rabbit uterus cytosol.

Published
2002

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