Search

Wenn über die wehrhafte Demokratie gestritten wird, ist der Ruf nach einer starken Zivilgesellschaft nicht fern. „Verfassungsschutz von unten“, „wehrhafte Demokratie light“, „ziviler Verfassungsschutz“, „intellectual militancy“ oder „konfliktfähige Zivilgesellschaft“ lauten die Forderungen. Fast alle Diskussionsbeiträge der laufenden Debatte haben gemeinsam, dass sie die Zivilgesellschaft in die Pflicht nehmen. Dabei ist es der Staat, der primär in die Verantwortung genommen werden muss. Sowohl Verfassungsrecht als auch Unionsrecht konkretisieren eine staatliche Pflicht zum Demokratieschutz. Entsprechend ist es staatliche Aufgabe, zivilgesellschaftliche Räume zu stärken und zu schützen.

The present article studies Mahmoud Dowlatabadi’s novel Yusef ’s Days and Nights and attempts to provide a different reading of the novel through the application of C. G. Jung’s theories on the collective unconscious and archetypes. From Jung’s perspective, the collective unconscious is the reservoir of psychic energy and the source of all human memories; also, the archetypes are universal mental structures the recognition of which becomes possible through the symbolic interpretation of dreams, fantasies, myths, and rituals. “Shadow” is one of the most important archetypes that, according to Jung, is the dark half of our being. This shadow is our alter-ego, and it is only when we accept it as a part of our being that we can achieve psychic equilibrium and complete the process of individuation. The process of individuation, and indeed of the conscious mind’s coming to terms with the ‘self,’ usually begins with suffering. Although this initial shock is not often recognized, it is a kind of summoning. However, Yusef (the protagonist of the novel) follows the path of denial and his projections of his fears and anxieties gradually make the distinction between illusion and reality difficult for him. Therefore, the confrontation with theshadow, although difficult and perhaps horrifying, is a necessary step on the road towards mental and psychical maturity.

Abstract: For many decades, it has been challenging to synthesize auxetic materials at the molecular level. Auxetic materials exhibit counterintuitive behavior; they expand perpendicularly to the direction in which they are stretched. An aromatic macrocycle containing a sequence of N-substituted and N-unsubstituted amides was designed to resemble the re-entrant structure found in macromolecular auxetic materials. Upon application of tensile force, bent cis amides change to linear trans amides. This was anticipated to trigger the expansion of the macrocycle perpendicular to the direction of the applied force. To investigate the proposed configurational change by atom force microscopy (AFM), we designed and prepared a cis–trans aramide motif incorporated into an end-functionalized polymer which ensured covalent attachment to the AFM tip. At large extensions, polymer chains were envisioned to unfold and induce cis–trans isomerization.

Purpose: Smear scores and induration sizes resulting from the PPD (tuberculin purified protein derivative) test can serve as indicators of whether a patient suffering from tuberculosis shows smear conversion or not. Methods: Using microbiological methods smear and sputum tests, patients diagnosed as infected with between 2002 and 2015 were included in this study. All of the assumed factors that may have a role in smear conversion were studied, in addition to the prolongation of tuberculosis. Results: 398 of 512 patients fulfilled all the inclusion criteria and formed the basis of this study. 215 patients (54%) were females and 183 (46%) were males. The median age for both men and women was 36 years. We found a statistically significant difference between the size of induration resulting from the PPD skin test and the rate of non-conversion (=0.002). Further univariate analysis also showed that smear grading and an induration size of ≥10 mm were independently associated with delayed smear conversion. Patients with cavitary lesions showed a higher rate of non-conversion after two months, which was not significant. We could not find any association between some of the variables, such as age, sex, weight, smoking, alcoholism, addictions, respiratory diseases, diabetes mellitus, alternative anti-TB treatment, and smear conversion. Conclusion: Intensified treatment and precautions against transmission should be especially considered for TB patients with high smear grading and an induration size of more than 10 mm.

Background: is the most common anaerobic pathogen isolated from surgical site infections (SSIs). Metronidazole resistance is increasing and the mechanisms of resistance are not clear in some isolates. The aim of the present study was to investigate the metronidazole susceptibility prevalence, and detect genes in isolates from SSIs. Methods: This study included 100 surgery patients with signs and symptoms indicative of SSIs. Syringe aspiration of the infected site was used to collect specimens. All specimens were cultured on BBA (Brucella blood agar), KVLB (kanamycin-vancomycin laked blood), and BBE (Bacteroides bile esculin) agar. The MIC (minimum inhibitory concentration) of metronidazole was determined by the agar dilution method according to the Clinical and Laboratory Standard Institute (CLSI). Then the PCR method was used to determine the presence of the gene.Results: In the present study, 26 were isolated from 100 SSIs specimens. Eight isolates were metronidazole resistant; the metronidazole MIC was 32 µg/mL for 7 isolates and 64 µg/mL for one isolate. All isolates were gene negative. Conclusion: The emergence of metronidazole-resistant limits the application of this drug for treatment and prophylaxis of SSIs. Thus, rapid identification of metronidazole-resistant is essential to restrict inappropriate, superfluous administration. In spite of various metronidazole resistance mechanisms other than that depending on the gene, detection of by PCR is unsuitable for identifying res isolates. Therefore, phenotypic methods are better to screen for and identify metronidazole-resistant .

Aim: The aim of this study was to investigate anaerobic and aerobic bacteria profile and determination of antibiotic susceptibility pattern in aerobic bacteria.Method: Specimens were cultured using optimal aerobic and anaerobic microbiological techniques. Identification of bacterial isolates was performed by standard microbiological methods and antibiotic susceptibility testing was performed according to the guidelines of Clinical and Laboratory Standards Institute (CLSI).Result: 92 bacterial strains were isolated from 60 samples of diabetic foot ulcers. Predominant aerobic bacteria isolated from these infections were (28%) followed by Enterobacteriaceae family (24%) including (15%), spp. (4%), spp. (4%), and coagulase-negative spp. (17%),spp. (15%), (7%) and spp. (4%). No spp. were isolated and 4% obtained from anaerobic culture. All Gram-positive isolates were susceptible to linezolid while all Enterobacteriaceae showed sensitivity to imipenem.Conclusion: Most of DFIs specimens were poly microbial infection and predominant bacteria were and . These wounds may require use of combined antimicrobial therapy for initial management.

Abstract MHC class I and II molecules are immunoregulatory cell surface glycoproteins, which selectively bind to and present antigenic peptides to T-lymphocytes. Murine and human studies show that variable peptide binding affinity to MHC II molecules influences Th1/Th2 responses by inducing distinctive cytokine expression. To examine the biological effects of peptide binding affinity to bovine MHC (BoLA), various self peptides (BoLA-DQ and fibrinogen fragments) and non-self peptides from ovalbumin (OVA), as well as VP2 and VP4 peptides from foot and mouth disease virus (FMD-V) were used to (1) determine binding affinities to the BoLA-DRB3*2703 allele, previously associated with mastitis susceptibility and (2) determine whether peptide binding affinity influences T-lymphocyte function. Peptide binding affinity was determined by a competitive assay using high affinity biotinylated self-peptide incubated with purified BoLA-DRB3*2703 in the presence of various concentrations of competing peptides. The concentrations of non-self peptide required to inhibit self-peptide binding by 50% (IC50) were variable, ranging from 26.92 to > 320 μM. Peptide-specific T-lymphocyte function was determined by measuring DNA synthesis, cell division, and IFN-γ production in cultures of mononuclear cells from a BoLA-DRB3*2703 homozygous cow. When compared to non-stimulated control cultures, differences in lymphocyte function were observed for all of the assessed parameters; however, peptide-binding affinity did not always account for the observed differences in lymphocyte function.