1. Komplikationen des Segmenttransports.
- Author
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Wagner, F., Militz, M., Högel, F., Bühren, V., and Hungerer, S.
- Subjects
- *
BONE injuries , *MESENCHYMAL stem cells , *BONE growth , *CALLUS , *CELL lines - Abstract
Segment transport for reconstruction of long bone defects >2 cm long is a safe procedure for restoration of length of anatomical extremities. Insufficient regeneration is a regularly occurring but rare complication. Exact figures on the frequency are lacking in the literature. Because mesenchymal stem cells (MSC) can be detected in distraction osteogenesis, bone growth factors can be detected in callus distraction and bone morphogenic protein (BMP) stimulates angiogenesis and differentiation of MSCs to osteogenic cell lines, preliminary attempts were made to treat disorders in callus maturation with administration of BMP. This article describes investigations on whether regeneration insufficiency after callus distraction can be successfully treated by administration of BMP. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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