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Clinical/methodical Issue: Perfusion computed tomography (CT) has its main application in the clinical routine diagnosis of neuroradiological problems., Standard Radiological Methods: Polyphase multi-detector spiral computed tomography is primarily used in liver diagnostics., Methodical Innovations: The use of perfusion CT is also possible for the diagnostics and differentiation of diffuse hepatic diseases., Performance: The differentiation between cirrhosis and cirrhosis-like parenchymal changes is possible. It also helps to detect early stages of malignant tumors., Achievements: However, there are some negative aspects, particularly that of radiation exposure., Practical Recommendations: This paper summarizes the technical basics and possible applications of perfusion CT in cases of diffuse liver disease and weighs up the advantages and disadvantages of the examinations.