805 results
Search Results
2. [Wie schreibe ich ein Paper].
- Author
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Schnichels S
- Published
- 2018
- Full Text
- View/download PDF
3. [Current clinical research landscape in Germany-an interdisciplinary position paper].
- Author
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Grünwald V, Bethge W, Blohmer JU, Burkhardt B, Dirksen U, Ebert M, Gschwend J, Gutzmer R, Henn D, Hermann K, Isbary G, Klußmann JP, Knauf W, Krause M, Luntz S, Paradies K, Piso P, Ryll B, Schmidt G, Sinn M, Stintzing S, Wedding U, Wesselmann S, and Reinacher-Schick A
- Published
- 2022
- Full Text
- View/download PDF
4. [Interdisciplinary position paper: the value of radiofrequency denervation in the treatment of chronic pain].
- Author
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Likar R, Auer J, Chavanne A, Ilias W, Kern M, Krepler P, Kress HG, Lischnig U, Maurer G, Sommer O, Spendel MC, Thurnher S, Wohak K, Wolf A, and Wölkhart M
- Subjects
- Austria, Denervation, Humans, Lumbar Vertebrae, Quality of Life, Treatment Outcome, Chronic Pain therapy, Low Back Pain surgery, Zygapophyseal Joint
- Abstract
Radiofrequency denervation has been established for many years as an important minimally invasive procedure for the treatment of chronic pain conditions. Positive experiences of many users for various indications are contrasted by a nonuniform evidence. With meticulous patient selection and correct assessment of the indications a longer term reduction of pain, a reduced need for analgesics and an improvement in the quality of life can be achieved. The aim of this interdisciplinary position paper is to present the value of radiofrequency denervation in the treatment of chronic pain. The summarized recommendations of the expert group are based on the available evidence and on the clinical experiences of Austrian centers that frequently implement the procedure. The position paper contains recommendations on patient selection and proven indications. We discribe safety aspects, complications, side effects and contraindications.
- Published
- 2021
- Full Text
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5. [Contrast medium-induced acute kidney injury-Consensus paper of the working group "Heart and Kidney" of the German Cardiac Society and the German Society of Nephrology].
- Author
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Latus J, Schwenger V, Schlieper G, Reinecke H, Hoyer J, Persson PB, Remppis BA, and Mahfoud F
- Subjects
- Acute Kidney Injury diagnosis, Acute Kidney Injury prevention & control, Consensus, Contrast Media administration & dosage, Humans, Risk Factors, Societies, Medical, Acute Kidney Injury chemically induced, Contrast Media toxicity, Kidney metabolism, Nephrology standards, Practice Guidelines as Topic standards
- Abstract
This consensus paper summarizes the expert consensus and recommendations of the working group "Heart and Kidney" of the German Cardiac Society (DGK) and the German Society of Nephrology (DGfN) on contrast medium-induced acute kidney injury. Potentially nephrotoxic contrast agents containing iodine are frequently used in interventional medicine and for computer tomography diagnostics. Acute kidney injury occurs in approximately 8-17% of patients exposed to contrast media. The risk factors and underlying pathophysiology are discussed and recommendations for the prophylaxis and treatment of contrast medium-induced acute nephropathy are presented.
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- 2021
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6. [Julius Springer Prize for Ophthalmology 2020 : Dr. Ameli Gabel-Pfisterer honored for outstanding original paper].
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Meyer Zu Tittingdorf M
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- History, 20th Century, Humans, Awards and Prizes, Ophthalmology
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- 2020
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7. [Position paper on medical cannabis and cannabis-based medicines in pain medicine].
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Petzke F, Karst M, Gastmeier K, Radbruch L, Steffen E, and Häuser W
- Subjects
- Analgesics therapeutic use, Chronic Pain drug therapy, Humans, Quality of Life, Cannabis chemistry, Medical Marijuana standards, Medical Marijuana therapeutic use, Pain drug therapy
- Abstract
Since March 2017, the prescription of medical cannabis at the expense of the statutory health insurance is possible after approval by the respective medical services. Chronic pain is the most common indication, as health claims data and the accompanying survey show. From the point of view of the law, a prescription is indicated in cases of serious illness, missing or not indicated established therapeutic approaches and a not entirely remote prospect of improvement of the illness or its symptoms. This describes a broader indication spectrum than can currently be based on randomised controlled clinical trials. There is weak evidence of low efficacy for neuropathic pain. For pain related to spasticity and cancer-related pain there is evidence of improvements in quality of life, but effects on pain are of little relevance. For all other indications, only an individual therapeutic trial can be justified based on the available external evidence. However, this usually corresponds to the demand of "a not entirely remote prospect" of a noticeably positive effect of medical cannabis. It is also problematic that almost no long-term studies for the application and efficacy of flowers and extracts are available.Current knowledge on the use of cannabis-based drugs and, more clearly, medical cannabis for chronic pain is insufficient. The increase in the number of countries with marketing authorisations or exemptions for medicinal cannabis or cannabis-based drugs for chronic pain will also pave the way for larger empirical and population-based studies that will further improve the evidence base of research and clinical use.
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- 2019
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8. [Concepts to improve the balance between clinical and scientific work-a thesis paper of the working group "Young Urologists" of the German Society of Urology].
- Author
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Ralla B, Leyh H, Steffens J, Burger M, Spachmann P, Borgmann H, and Struck JP
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- Germany, Humans, Societies, Medical, Urologists, Urology
- Published
- 2019
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9. [Interdisciplinary position paper "Perioperative pain management"].
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Likar R, Jaksch W, Aigmüller T, Brunner M, Cohnert T, Dieber J, Eisner W, Geyrhofer S, Grögl G, Herbst F, Hetterle R, Javorsky F, Kress HG, Kwasny O, Madersbacher S, Mächler H, Mittermair R, Osterbrink J, Stöckl B, Sulzbacher M, Taxer B, Todoroff B, Tuchmann A, Wicker A, and Sandner-Kiesling A
- Subjects
- Algorithms, Analgesia, Patient-Controlled methods, Austria, Chronic Pain classification, Chronic Pain diagnosis, Chronic Pain therapy, Combined Modality Therapy methods, Documentation methods, Humans, Pain Measurement methods, Pain, Postoperative classification, Pain, Postoperative diagnosis, Precision Medicine methods, Risk Factors, Guideline Adherence, Interdisciplinary Communication, Intersectoral Collaboration, Pain Management methods, Pain, Postoperative therapy, Perioperative Period
- Abstract
Despite many positive developments, postoperative pain and its treatment is still not always given the necessary attention. Severe pain after surgical procedures affects a significant proportion of patients. This very fact is not only detrimental to the immediate recovery process, but can also form the basis for the development of chronic pain conditions.An adequate and effective management of perioperative pain requires appropriate organizational structures. This multidisciplinary paper which was initiated by the Austrian Society for Anaesthesiology and Intensive Care and the Austrian Pain Society and developed together with numerous specialist and professional societies dealing with the subject aims at supporting the organization of perioperative pain management structures and to make best use of proven concepts. Additional recommendations describe specific interventions for selected types of intervention.
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- 2017
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10. [Metastatic prostate cancer : Update: position paper for the use of chemotherapy].
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Ohlmann CH, Goebell PJ, Grimm MO, Klier J, König F, Machtens S, Schostak M, Schrader AJ, and Albers P
- Subjects
- Androgen Antagonists therapeutic use, Antineoplastic Agents adverse effects, Clinical Trials, Phase III as Topic, Docetaxel adverse effects, Docetaxel therapeutic use, Early Medical Intervention, Evidence-Based Medicine, Humans, Male, Neoplasm Metastasis, Prostatic Neoplasms mortality, Prostatic Neoplasms, Castration-Resistant mortality, Randomized Controlled Trials as Topic, Survival Rate, Taxoids adverse effects, Antineoplastic Agents therapeutic use, Prostatic Neoplasms drug therapy, Prostatic Neoplasms pathology, Prostatic Neoplasms, Castration-Resistant drug therapy, Prostatic Neoplasms, Castration-Resistant pathology, Taxoids therapeutic use
- Abstract
Background: Taxen-based chemotherapy has been established as an effective treatment option in castration-resistant metastatic prostate cancer (mCRPC). Randomized phase III studies, however, have shown that even in the hormone-naïve metastatic state, the early use of chemotherapy in addition to the classical androgen deprivation therapy (ADT) approach leads to a significant increase in median overall survival., Objective: This position paper aims to provide current data and orientation in the evidence-based treatment of mPC patients in daily clinical practice., Materials and Methods: A German group of clinical experts analyzed the current data and developed criteria for the treatment of mPC patients in daily clinical practice., Results: In the current treatment of hormone-naïve mPC, a beneficial effect of chemotherapy in addition to ADT has become evident. Provided patients are in an appropriate condition, those with a high metastatic load should receive chemotherapy in addition to ADT. Especially in high-risk mCRPC patients (PSA >114 ng/ml, visceral metastasis, ADT response <12 months, tumor-associated complaints), first-line chemotherapy is indicated. After docetaxel failure, continuous treatment with cabazitaxel shows superior overall survival compared to sustained antihormonal therapy., Conclusion: Chemotherapy is firmly established in treating patients with mCRPC. Long-term, it will be important to identify molecular predictors. The authors suggest the early use of chemotherapy in hormone-naïve mPC, but note that the approval in this indication is currently nonexistent. After disease progression, patients should be treated analogous to mCRPC.
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- 2017
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11. [Drug therapy of hormone-sensitive metastatic prostate cancer : Consensus paper of the AKO/AUO].
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Ohlmann CH, Gschwend J, and Miller K
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- Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Combined Modality Therapy methods, Docetaxel, Evidence-Based Medicine, Germany, Humans, Male, Medical Oncology standards, Middle Aged, Neoplasm Metastasis, Survival Rate, Treatment Outcome, Urology standards, Androgen Antagonists administration & dosage, Castration mortality, Practice Guidelines as Topic, Prostatic Neoplasms mortality, Prostatic Neoplasms therapy, Taxoids administration & dosage
- Abstract
Background: The standard treatment of patients with metastatic, hormone-sensitive prostate cancer (mCSPC) currently consists of medical or surgical castration. The addition of a cytotoxic chemotherapy was unable to provide a survival benefit over castration alone in several clinical trials using different chemotherapy regimens., Results: Even a preliminary clinical trial using a docetaxel-based chemohormonal combination did not show a survival benefit. In contrast, two more recently published clinical trials (CHAARTED and STAMPEDE) using docetaxel in combination with castration provided evidence for a substantial improvement in overall survival. The survival benefit was 14 and 22 months in the two trials. In addition, the CHAARTED trial showed that patients with high volume disease may benefit most from chemohormonal treatment., Conclusion: According to the current available evidence, the new standard of treatment for patients therefore consists of castration in combination with docetaxel-based chemotherapy and should be offered to all patients who are fit to receive chemotherapy.
- Published
- 2016
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12. [Bündnis JUNGE ÄRZTE: position paper : Compatibility of family and career - where is the change in minds?].
- Author
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Arnold H
- Subjects
- Career Mobility, Germany, Burnout, Professional prevention & control, Burnout, Professional psychology, Family psychology, Job Satisfaction, Work Schedule Tolerance psychology, Workplace psychology
- Published
- 2016
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13. [Young doctors do want to do research : The second position paper of the Bündnis JUNGE ÄRZTE against the decreased appeal of academic research].
- Author
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Arnold H
- Subjects
- Germany, Academic Medical Centers organization & administration, Attitude of Health Personnel, Career Choice, Internship and Residency organization & administration, Needs Assessment organization & administration, Societies, Medical organization & administration
- Published
- 2015
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14. [Metastasized prostate cancer. Position paper on the use of chemotherapy].
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Ohlmann CH, Duensing S, Eichenauer R, König F, Machtens S, Schostak M, Thomas C, and Albers P
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- Carcinoma diagnosis, Drug Therapy standards, Germany, Humans, Male, Prostatic Neoplasms, Castration-Resistant diagnosis, Antineoplastic Agents administration & dosage, Carcinoma drug therapy, Carcinoma secondary, Medical Oncology standards, Practice Guidelines as Topic, Prostatic Neoplasms, Castration-Resistant drug therapy
- Abstract
Background: Antihormonal and cytotoxic therapy options are available for the therapy of metastasized prostate cancer (mPC). Because no comparative studies are available, especially for castration-resistant prostate cancer (mCRCP), it remains unclear which patients will profit best from which therapy., Objectives: Previous data on the sequence of the various therapy options show that correct selection of the first line therapy for mCRPC can have an influence on the prognosis of the patient. In this position paper the various therapy options are critically illustrated and the clinical and pathohistological criteria for selection of the first line therapy of mCRPC are discussed., Results: Molecular markers are an important aid for future patient selection and individualized therapy for optimal use of the available forms of therapy.
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- 2015
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15. [Chances and risks of blood-based molecular pathological analysis of circulating tumor cells (CTC) and cell-free DNA (cfDNA) in personalized cancer therapy: positional paper from the study group on liquid biopsy of the working group for molecular pathology in the German Society of Pathology (DGP)].
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Dahl E, Jung A, Fassunke J, Hummel M, Penzel R, Dietmaier W, and Laßmann S
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- Biopsy, Humans, Neoplasms diagnosis, Neoplastic Cells, Circulating pathology, Predictive Value of Tests, Prognosis, Risk Factors, Tumor Burden, Cell-Free System pathology, DNA, Neoplasm genetics, Molecular Diagnostic Techniques, Neoplasms genetics, Neoplasms therapy, Neoplastic Cells, Circulating metabolism, Precision Medicine methods
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- 2015
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16. [Position paper of the "Bündnis JUNGE ÄRZTE" on the increasing workload in the German health care system].
- Author
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Arnold H
- Subjects
- Germany, Delivery of Health Care organization & administration, Internship and Residency organization & administration, Needs Assessment organization & administration, Societies, Medical organization & administration, Workload
- Published
- 2014
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17. [Multimodal pain therapy for treatment of chronic pain syndrome. Consensus paper of the ad hoc commission on multimodal interdisciplinary pain management of the German Pain Society on treatment contents].
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Arnold B, Brinkschmidt T, Casser HR, Diezemann A, Gralow I, Irnich D, Kaiser U, Klasen B, Klimczyk K, Lutz J, Nagel B, Pfingsten M, Sabatowski R, Schesser R, Schiltenwolf M, Seeger D, and Söllner W
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- Germany, Humans, Pain Clinics, Societies, Medical, Syndrome, Chronic Pain therapy, Combined Modality Therapy methods, Cooperative Behavior, Interdisciplinary Communication, Pain Management methods
- Abstract
Multimodal pain management is a comprehensive treatment of complex chronic pain syndromes. In addition to medical therapy various other specialized therapeutic interventions based on the biopsychosocial model of pain origin and chronic pain development, are added. During the last few years treatment centers for chronic pain have been established throughout Germany. Multimodal pain management has been included in the official catalogue of the recognized medical procedures for day clinic units as well as for inpatient pain management. In daily practice there is, however, still a lack of clarity and of consistency about the components that multimodal pain management should contain. This is the reason for the ad hoc commission on multimodal interdisciplinary pain management of the German Pain Society to propose the following position paper that has been worked out in a multilevel and interdisciplinary consensus process. The paper describes the mandatory treatment measures in the four core disciplines of multimodal pain management, pain medicine, psychotherapy, exercise therapy including physiotherapy and assistant medical professions including nurses.
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- 2014
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18. [Metastatic castration-resistant prostate cancer: position paper for structured therapy monitoring].
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Miller K, Albers P, Eichenauer R, Geiges G, Grimm MO, König F, Mickisch G, Pfister D, Schwentner C, Suttmann H, and Zastrow S
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- Androstenes, Androstenols adverse effects, Androstenols therapeutic use, Antineoplastic Agents adverse effects, Benzamides, Disease Progression, Docetaxel, Drug Resistance, Neoplasm, Humans, Male, Neoplasm Staging, Nitriles, Phenylthiohydantoin adverse effects, Phenylthiohydantoin analogs & derivatives, Phenylthiohydantoin therapeutic use, Prognosis, Prostatic Neoplasms, Castration-Resistant pathology, Taxoids adverse effects, Taxoids therapeutic use, Antineoplastic Agents therapeutic use, Prostatic Neoplasms, Castration-Resistant drug therapy
- Abstract
This position paper is intended to help to structure and to standardize therapy monitoring in patients with metastatic castration-resistant prostate cancer (mCRPC). With the treatment options available today, patients with metastatic disease can often maintain good quality of life and stable disease for several years. It is crucial that once a therapy becomes insufficiently effective that it be replaced in a timely manner by a new treatment option. From a prognostic point of view, it is important that patients receive as many as possible and in the ideal case all currently available treatment options.
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- 2014
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19. [Remote management of musculoskeletal pain : A pragmatic approach to the implementation of video and phone consultations in musculoskeletal practice. German version].
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Hohenschurz-Schmidt D, Scott W, Park C, Christopoulos G, Vogel S, and Draper-Rodi J
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- Humans, Musculoskeletal Pain diagnosis, Musculoskeletal Pain therapy, Remote Consultation
- Abstract
Introduction: Remote consultations through phone or video are gaining in importance for the treatment of musculoskeletal pain across a range of health care providers. However, there is a plethora of technical options for practitioners to choose from, and there are various challenges in the adaptation of clinical processes as well as several special considerations regarding regulatory context and patient management. Practitioners are faced with a lack of high-quality peer-reviewed resources to guide the planning and practical implementation of remote consultations., Objectives: This Clinical Update seeks to provide practical guidance for the planning and implementation of remote consultations for the management and treatment of people with musculoskeletal pain., Methods: Recommendations are based on a brief overview of the relevant research regarding phone and video consultations for musculoskeletal practice and derived from the literature, relevant guidelines, and practical experience., Results: The technical feasibility of remote consultations for musculoskeletal complaints is good, patient satisfaction is high, and a growing body of evidence supports its comparative effectiveness to in-person consultations in some circumstances for improving pain and functioning. We consider in detail practical aspects such as the choosing of hardware and software, we touch on the legal and regulatory context, and we focus on the adaptation of clinical processes and communication., Conclusion: This Clinical Update draws together best-practice evidence in a practically applicable format, enabling therapists who are working with people with pain to directly apply this knowledge to their individual clinical settings and the requirements of their patients., (© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2023
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20. [Clinical efficacy of auricular vagus nerve stimulation in the treatment of chronic and acute pain : A systematic review].
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Likar R, Perruchoud C, Kampusch S, Köstenberger M, Sator S, Stremnitzer C, Wolf A, and Neuwersch-Sommeregger S
- Abstract
Background: Current guidelines recommend a personalized, multimodal, and interdisciplinary approach for the treatment of chronic pain. Already in the acute treatment of postoperative pain, it can be useful to minimize risk factors for chronification. Auricular vagus nerve stimulation (aVNS) could be an effective non-drug therapy for the treatment of chronic and acute pain., Aim of the Work: The aim of this systematic review is to evaluate the clinical efficacy of aVNS in chronic and acute pain as well as its effect on medication intake., Materials and Methods: A systematic literature search was carried out on the application of auricular electrical stimulation in chronic and acute pain. Studies were classified according to their level of evidence and evaluated via the Jadad scale as well as their scientific validity, and then analyzed in terms of indication, method, stimulation parameters, duration of treatment, efficacy, and safety., Results: Twenty studies on chronic pain indications, ten studies on acute postoperative pain, as well as seven studies on experimental acute pain were identified and analyzed. The search revealed a total of n = 1105 aVNS-treated patients. The best evidence on the efficacy of aVNS is available for the indications chronic low back pain, chronic cervical syndrome, chronic abdominal pain, and chronic migraine as well as acute postoperative pain in oocyte aspiration, laparoscopic nephrectomy, and open colorectal surgery. Additionally a significant reduction in analgesic or opiate intake was evident in most studies. In three randomized controlled trials in chronic pain patients, a sustainable pain reduction over a period of up to 12 months was shown. Overall, aVNS was very well tolerated., Conclusion: This review indicates that aVNS can be a complementary and effective non-drug treatment for patients with chronic and acute postoperative pain. Future studies in these indications should focus on standardizing and optimizing treatment parameters, inclusion of quality-of-life outcome parameters, and longer follow-up periods to better understand the sustainable therapeutic effect of aVNS., (© 2023. The Author(s).)
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- 2023
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21. [Artificial intelligence (AI) in radiology? : Do we need as many radiologists in the future?]
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Bonekamp D and Schlemmer HP
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- Forecasting, Humans, Radiography, Radiologists, Artificial Intelligence, Radiology
- Abstract
We are in the middle of a digital revolution in medicine. This raises the question of whether subjects such as radiology, which is superficially concerned with the interpretation of images, will be particularly changed by this revolution. In particular, it should be discussed whether in the future the completion of initially simpler, then more complex image analysis tasks by computer systems may lead to a reduced need for radiologists. What distinguishes radiology in particular is its key position between advanced technology and medical care. This article discusses that not only radiology but every medical discipline will be affected by innovations due to the digital revolution, and that a redefinition of medical specialties focusing on imaging and visual interpretation makes sense and that the arrival of artificial intelligence (AI) in radiology is to be welcomed in the context of ever larger amounts of image data-to at all be able to handle the increasing amount of image data in the future at the current number of radiologists. In this respect, the balance between research and teaching in comparison to patient care is more difficult to maintain in the academic environment. AI can help improve efficiency and balance in the areas mentioned. With regard to specialist training, information technology topics are expected to be integrated into the radiological curriculum. Radiology acts as a pioneer designing the entry of AI into medicine. It is to be expected that by the time radiologists can be substantially replaced by AI, the replacement of human contributions in other medical and non-medical fields will also be well advanced., (© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2022
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22. [Renal denervation : Really an alternative to reducing blood pressure?]
- Author
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Striepe K, Schiffer M, and Schmieder R
- Subjects
- Antihypertensive Agents therapeutic use, Blood Pressure physiology, Denervation methods, Humans, Sympathectomy methods, Treatment Outcome, Hypertension drug therapy, Hypertension therapy, Kidney
- Abstract
Since the current guidelines were published in 2018, a total of 5 sham-controlled high-quality studies evaluating renal denervation have been conducted and the results were published. These five studies clearly confirmed the efficacy and safety of renal denervation, which correspond to the knowledge of the Clinical Consensus Conference. Thus, an update of the guidelines for the treatment of arterial hypertension regarding the clinical significance of renal denervation is urgently necessary. For this reason, the position paper of the working group of the European Society of Hypertension on the current state of renal denervation was reviewed. An approval of this procedure can soon be expected. In Germany there is a diagnosis-related group (DRG) for the reimbursement of renal denervation, which was suspended due to the erroneous Symplicity 3 study. This DRG should be revived in practice by a structured process of the implementation of renal denervation. It will then be a joint task of treating physicians and specialists in certified centers to identify eligible patients. In the future, antihypertensive treatment will consist of three pillars: lifestyle measures, pharmacotherapy and interventional treatment. These three treatment options should not be regarded as competitive (which is better) but alternative (patient preference) and additive (the aim is blood pressure control). It is the task of the treating physician to provide the patient with the ideal treatment concept. Clearly, renal denervation will not replace antihypertensive pharmacotherapy; however, it can lead to a reduction of the drug burden and increase of patient adherence to medication. It represents an option of modern antihypertensive treatment and will also become increasingly more important in special patient groups., (© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2022
- Full Text
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23. [Patient-reported outcomes in chronic diseases under treatment with cannabis medicines : Analysis of the results of the Copeia survey].
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Gastmeier K, Ihlenfeld A, Gastmeier A, Hirt G, Landschaft A, and Wirz S
- Abstract
Background: The survey of Copeia captured early 2022 patient-reported outcomes (PRO) in Germany under cannabis medicinal product (CAM) therapy, with particular attention to symptoms, symptom changes, indications, side effects, dosages, and cost bearers., Goal: This study investigated the question of whether associations emerge from the results that could play a role in the indication and treatment monitoring of CAM in chronically ill patients., Materials and Methods: A standardized questionnaire was administered online nationwide in dialogue form over a 15-week period to collect itemized symptoms and PRO. Recruitment was supported by pharmacies, prescribing physicians, and patient associations. Inclusion criteria included physician-prescribed CAM therapy., Results and Discussion: Of 1582 participants, 1030 data sets (65%) could be completely analyzed. There was a heterogeneous patient population, whose common feature was disease chronicity. The frequency distribution of symptoms showed a homogeneous pattern for the respective indications, in which the most frequent six (pain 71%, sleep disturbance 64%, stress/tension 52%, inner restlessness 52%, depressive mood 44% and muscle tension 43%) seem to have a special significance. According to subjective assessment, quality of life improved significantly in 84% of all participating patients., Conclusion: A symptom matrix (SMX) composed of different symptoms seems to play a special role in CAM therapy to improve the quality of life of chronically ill patients, regardless of the underlying disease. The SMX could contribute to the identification of an indication and to targeted treatment monitoring., (© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2024
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24. [Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure : Short version of the S3 guideline].
- Author
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Boeken U, Ensminger S, Assmann A, Schmid C, Werdan K, Michels G, Miera O, Schmidt F, Klotz S, Starck C, Pilarczyk K, Rastan A, Burckhardt M, Nothacker M, Muellenbach R, Zausig Y, Haake N, Groesdonk H, Ferrari M, Buerke M, Hennersdorf M, Rosenberg M, Schaible T, Köditz H, Kluge S, Janssens U, Lubnow M, Flemmer A, Herber-Jonat S, Wessel L, Buchwald D, Maier S, Krüger L, Fründ A, Jaksties R, Fischer S, Wiebe K, Hartog C, Dzemali O, Zimpfer D, Ruttmann-Ulmer E, Schlensak C, Kelm M, and Beckmann A
- Subjects
- Extracorporeal Circulation, Germany, Humans, Life Support Systems, Extracorporeal Membrane Oxygenation, Shock
- Abstract
In Germany, a remarkable increase regarding the usage of extracorporeal membrane oxygenation (ECMO) and extracorporeal life support (ECLS) systems has been observed in recent years with approximately 3000 ECLS/ECMO implantations annually since 2015. Despite the widespread use of ECLS/ECMO, evidence-based recommendations or guidelines are still lacking regarding indications, contraindications, limitations and management of ECMO/ECLS patients. Therefore in 2015, the German Society of Thoracic and Cardiovascular Surgery (GSTCVS) registered the multidisciplinary S3 guideline "Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure" to develop evidence-based recommendations for ECMO/ECLS systems according to the requirements of the Association of the Scientific Medical Societies in Germany (AWMF). Although the clinical application of ECMO/ECLS represents the main focus, the presented guideline also addresses structural and economic issues. Experts from 17 German, Austrian and Swiss scientific societies and a patients' organization, guided by the GSTCVS, completed the project in February 2021. In this report, we present a summary of the methodological concept and tables displaying the recommendations for each chapter of the guideline., (© 2021. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2021
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25. [On the quality of bibliometric analyses].
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Miller C and Wenzel V
- Subjects
- Humans, Bibliometrics, Publishing
- Published
- 2021
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26. [Cannabis and cannabinoids for the treatment of acute and chronic pain].
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Schäfer M and Tafelski S
- Subjects
- Humans, Cannabidiol, Cannabinoids adverse effects, Cannabis, Chronic Pain drug therapy, Medical Marijuana therapeutic use
- Abstract
Since the Act on the medical use of cannabis, at which cannabis-based medicines and cannabinoids became law, there has been an exponential increase in prescriptions for the acquisition of cannabis for medical purposes. The aim of this leading article is to compile and assess the currently available relevant clinical evidence for the use of cannabis and cannabinoids for treatment of acute and chronic pain. Based on the systematic literature review "Cannabis-Potential and risks (CAPRIS)" commissioned by the German Federal Ministry of Health and the recently published recommendations of the European Pain Federation EFIC, this article aims to give an orientation aid for the decision-making process in the clinical routine.
- Published
- 2021
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27. [Training module extracorporeal life support (ECLS): consensus statement of the DIVI, DGTHG, DGfK, DGAI, DGIIN, DGF, GRC and DGK].
- Author
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Trummer G, Müller T, Muellenbach RM, Markewitz A, Pilarczyk K, Bittner S, Boeken U, Benk C, Baumgärtel M, Bauer A, and Michels G
- Subjects
- Consensus, Critical Care, Humans, Life Support Systems, Cardiopulmonary Resuscitation, Extracorporeal Membrane Oxygenation
- Abstract
Mechanical circulatory support using extracorporeal life support systems (ECLS) has significantly increased in recent years. These critically ill patients pose special challenges to the multiprofessional treatment team and require comprehensive, interdisciplinary and interprofessional concepts. For this reason, to ensure the best possible patient care a standardized ECLS training module has been created at national specialist society level, taking emergency and intensive care management into account.
- Published
- 2021
- Full Text
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28. [Individualized use of levosimendan in cardiac surgery].
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Woehrle T, Mehringer L, Juchem G, Dashkevich A, Weis M, Schünemann M, and Kilger E
- Subjects
- Cardiac Output, Low drug therapy, Cardiac Output, Low prevention & control, Cardiotonic Agents therapeutic use, Humans, Hydrazones therapeutic use, Postoperative Complications epidemiology, Postoperative Complications prevention & control, Retrospective Studies, Simendan pharmacology, Stroke Volume, Ventricular Function, Left, Cardiac Surgical Procedures, Pyridazines therapeutic use
- Abstract
Background: Levosimendan is a cardiac inotrope that augments myocardial contractility without increasing myocyte oxygen consumption. Additionally, levosimendan has been shown to exhibit anti-inflammatory, antioxidative, and other cardioprotective properties and is approved for treatment of heart failure. Recent studies indicated that these beneficial effects can be achieved with doses lower than the standard dose of 12.5 mg. Patients with preoperatively diagnosed left ventricular ejection fraction (LVEF) ≤40% received 1.25 mg levosimendan after induction of anesthesia. After surgery, administration of low-dose levosimendan was repeated until cardiovascular stability was achieved., Objective: This study aimed to evaluate if pharmacological preconditioning with 1.25 mg levosimendan in patients with LVEF ≤40% altered the postoperative need for inotropic agents, the incidence of newly occurring atrial fibrillation, renal replacement therapy, mechanical circulatory support and 30-day mortality. The cumulative dosage of levosimendan was recorded to assess the required dosage in the context of individualized treatment., Material and Methods: This retrospective study included patients with preoperatively diagnosed LVEF ≤40% who underwent cardiac surgery at this institution between January 2015 and December 2018 and who received 1.25 mg levosimendan after induction of anesthesia to prevent postoperative low cardiac output syndrome. Based on echocardiography results, invasive hemodynamic monitoring, and central venous or mixed venous oxygen saturation and lactate clearance, repetitive doses of levosimendan in 1.25 mg increments could be postoperatively administered until cardiovascular stability was achieved. The results were compared to the current literature., Results: We identified 183 patients with LVEF <40% who received pharmacological preconditioning with 1.25 mg levosimendan. Maximum doses of epinephrine, incidence of atrial fibrillation, need for renal replacement therapy and 30-day mortality were found to be below the published rates of comparable patient collectives. In 73.2% of patients, a cumulative dosage of 5 mg levosimendan or less was considered sufficient., Conclusion: The presented concept of pharmacological preconditioning with 1.25 mg levosimendan followed by individualized additional dosing in cardiac surgery patients with preoperative LVEF ≤40% suggests that this concept is safe, with possible advantages regarding the need of inotropic agents, renal replacement therapy, and 30-day mortality, compared to the current literature. Individualized treatment with levosimendan to support hemodynamics and a timely reduction of inotropic agents needs further confirmation in randomized trials.
- Published
- 2021
- Full Text
- View/download PDF
29. [Antibiotic prophylaxis for endourological interventions considering antibiotic stewardship].
- Author
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Kranz J, Schneidewind L, Pilatz A, and Wagenlehner FRA
- Subjects
- Anti-Bacterial Agents therapeutic use, Antibiotic Prophylaxis, Humans, Surgical Wound Infection prevention & control, Antimicrobial Stewardship, Urinary Tract Infections drug therapy, Urinary Tract Infections etiology, Urinary Tract Infections prevention & control
- Abstract
Perioperative antibiotic prophylaxis in endourology is used to reduce or avoid postoperative surgical site infections and complicated urinary tract infections. Special attention is paid to antibiotic stewardship strategies to avoid the continuing selection of antibiotics and multidrug-resistant uropathogens as well as collateral damage to the microbiome. The individual risk profile, the local resistance situation, the expected pathogen spectrum, the pharmacokinetics and the approval of each substance are important aspects to be considered in the indications and selection of perioperative antibiotic prophylaxis. Furthermore, applicable hygiene regulations and the surgical care of an intervention must be observed.
- Published
- 2021
- Full Text
- View/download PDF
30. [Pain and cervical dystonia].
- Author
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Hamami F and Bäumer T
- Subjects
- Humans, Pain drug therapy, Torticollis diagnosis, Torticollis therapy, Torticollis complications, Botulinum Toxins therapeutic use
- Abstract
Background: Dystonia is a hyperkinetic movement disorder that results in twisting, cramps and tremors due to sustained or intermittent muscle contractions. Cervical dystonia is the most common form of dystonia, in which the head, neck and/or shoulder areas are affected. In addition to these motor symptoms, pain and psychiatric symptoms are frequent in (cervical) dystonia., Objective: Description of the incidence and evaluation of pain in cervical dystonia, summary and discussion of treatment options and effects., Material and Methods: In this review article the results in the scientific literature on pain in dystonia are summarized and discussed., Results: Compared to other forms of dystonia, pain occurs most frequently in patients with cervical dystonia. A large proportion of patients with cervical dystonia suffer from pain, which contributes most to impairment of the patient. The motor symptoms of dystonia are usually treated with botulinum toxin injections. These have a muscle relaxing effect and also relieve pain. The study situation on the occurrence and treatment of pain in other forms of dystonia is so far very limited. Pain can dominate the clinical picture in patients with cervical dystonia. Evaluation of pain in cervical dystonia can be performed using standardized questionnaires., Conclusion: It is important to ask patients with cervical dystonia about pain and to consider it in treatment planning and evaluation. Vice versa, if pain is present the possibility of a causative dystonia should also be considered. For pain assessment there are some newly developed questionnaires to assess pain in a standardized way in patients with dystonia. Further research is needed to better understand the pathomechanisms of pain in dystonia., (© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF
31. [Tumor-associated pain].
- Author
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Wirz S, Keßler J, and Hofbauer H
- Subjects
- Humans, Analgesics therapeutic use, Palliative Care methods, Pain Management, Cancer Pain therapy, Cancer Pain drug therapy, Neuralgia therapy, Neuralgia drug therapy
- Abstract
Tumor-associated pain has a high prevalence and is still a challenging aspect of pain medicine. Treatment-related etiologies often coexist with pain caused by the oncological disease itself. For cancer pain as well, a pathophysiologically oriented analysis of nociceptive, nociplastic and neuropathic pain is advisable for planning a tailored treatment. The analgesic three-step ladder of the World Health Organization (WHO) should be customized in this context, incorporating antineuropathic or antihypersensitizing pharmacological approaches as well as minimally invasive techniques. Psycho-oncological and exercise therapy interventions should be considered. In cases of long-term courses of treatment or following curative oncological treatment, chronically persistent or chronic tumor-associated pain can occur, necessitating multimodal therapeutic approaches analogue to noncancer pain conditions. Close integration with palliative medicine enhances the therapeutic effectiveness during the transition from nonpalliative to palliative treatment phases., (© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF
32. [Short paths to diagnosis with artificial intelligence: systematic literature review on diagnostic decision support systems].
- Author
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Sellin J, Pantel JT, Börsch N, Conrad R, and Mücke M
- Subjects
- Humans, Artificial Intelligence, Rare Diseases
- Abstract
Background: Rare diseases are often recognized late. Their diagnosis is particularly challenging due to the diversity, complexity and heterogeneity of clinical symptoms. Computer-aided diagnostic aids, often referred to as diagnostic decision support systems (DDSS), are promising tools for shortening the time to diagnosis. Despite initial positive evaluations, DDSS are not yet widely used, partly due to a lack of integration with existing clinical or practice information systems., Objective: This article provides an insight into currently existing diagnostic support systems that function without access to electronic patient records and only require information that is easily obtainable., Materials and Methods: A systematic literature search identified eight articles on DDSS that can assist in the diagnosis of rare diseases with no need for access to electronic patient records or other information systems in practices and hospitals. The main advantages and disadvantages of the identified rare disease diagnostic support systems were extracted and summarized., Results: Symptom checkers and DDSS based on portrait photos and pain drawings already exist. The degree of maturity of these applications varies., Conclusion: DDSS currently still face a number of challenges, such as concerns about data protection and accuracy, and acceptance and awareness continue to be rather low. On the other hand, there is great potential for faster diagnosis, especially for rare diseases, which are easily overlooked due to their large number and the low awareness of them. The use of DDSS should therefore be carefully considered by doctors on a case-by-case basis., (© 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF
33. [Body, mind and culture : The complex dimensions of experiencing pain].
- Author
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Tesarz J
- Abstract
This article deals with the interrelationship between body, mind and culture with respect to being healthy and being ill. If one wants to treat not only sickness but also sick people, it is helpful to be aware not only of the somatic and psychological dimensions of a disease but also of the "cultural" dimension of a disease. Based on personal reflections and supplemented by a focused literature search this article provides insights into how cultural influences not only affect the experience of illness but also decide how an illness is dealt with individually and socially. Furthermore, it is shown that not only being sick but also the sick body can be understood in somatic, psychological and cultural dimensions and that a distinction must be made between the body as it physically is and as it is subjectively perceived. Finally, an insight into the complexity of the somatopsychic and psychosomatic interactions is provided in order to derivatively show how mental stress can lead to physical pain and physical pain can become a mental stressor., (© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF
34. [Mind-body medicine in pain management].
- Author
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Paul A
- Subjects
- Humans, Pain Management, Stress, Psychological therapy, Meditation, Yoga, Complementary Therapies, Chronic Pain therapy, Mindfulness
- Abstract
Chronic pain affects around 3 million people in Germany. The drug therapies used are only effective to a limited extent and sometimes have considerable side effects. Methods of mind-body medicine (MBM) including especially mindfulness-based stress reduction (MBSR), meditation and yoga, can significantly reduce the perceived intensity of the pain. Combined with evidence-based complementary medicine, MBM as mind-body medicine in integrative and complementary medicine (MICOM) is an effective instrument for self-efficacy and self-care with very few side effects. The reduction of stress plays a key role in this process., (© 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2023
- Full Text
- View/download PDF
35. [Minimally invasive valvular interventions by a multidisciplinary team : Safe and successful patient treatment].
- Author
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von Dossow V and Zwißler B
- Subjects
- Humans, Minimally Invasive Surgical Procedures, Patient Care Team
- Published
- 2021
- Full Text
- View/download PDF
36. [Treatment recommendations in cardio-oncology: where are we?]
- Author
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Müller OJ and Baldus CD
- Subjects
- Humans, Medical Oncology trends, Neoplasms complications, Antineoplastic Agents adverse effects, Cardiotoxicity prevention & control, Heart Diseases chemically induced, Neoplasms drug therapy
- Abstract
This article provides an overview of current prevention and treatment options for typical cardiovascular side effects of oncological therapies as well as cardiovascular complications of malignant disease. Focus is put on the prevention and treatment of heart failure under potentially cardiotoxic cancer therapies. In addition, current options for the treatment of common venous thromboembolism in cancer patients will be discussed.
- Published
- 2020
- Full Text
- View/download PDF
37. [Biomarkers in cardio-oncology patients].
- Author
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Totzeck M, Glas M, and Rassaf T
- Subjects
- Antineoplastic Agents therapeutic use, Biomarkers blood, Heart Diseases, Heart Failure diagnosis, Humans, Neoplasms complications, Neoplasms drug therapy, Antineoplastic Agents adverse effects, Heart Failure chemically induced, Natriuretic Peptides analysis, Neoplasms pathology
- Abstract
In recent decades, major advances in the treatment of malignant diseases have significantly improved long-term survival. However, this has increased the spectrum of side effects of these treatment methods, particularly for the cardiovascular system. Cardiotoxicity can be acute and chronic, including hypertension, heart failure, arrhythmias, acute myocardial infarction, venous thromboembolism, stroke, and valvular heart disease. While the occurrence of cardiotoxicity is known for many older cancer therapies, it needs to be largely evaluated for newer forms of therapy. Diagnosing possible cardiotoxic side effects is essential for optimal treatment, but remains a challenge. Troponin and the natriuretic peptides play an essential role as cardiac biomarkers in the diagnosis of conventional heart diseases. However, they also appear to play an important role in the detection of cardiotoxicity, as well as in the treatment of cardio-oncology patients. Elevated troponin or B-type natriuretic peptide (BNP)/N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are associated with increased overall mortality and were associated with the development of heart failure in selected cohorts. Troponin can also be used to identify myocarditis associated with immune checkpoint inhibitor therapy. This overview summarizes the current knowledge about biomarkers for the detection of cardiotoxicity due to tumor therapy. Possible clinical recommendations for the detection of cardiotoxic effects using biomarkers are also outlined.
- Published
- 2020
- Full Text
- View/download PDF
38. [Evidence-based interventional pain medicine : Progress over the past 10 years].
- Author
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Klessinger S, Legat M, and Schneider M
- Subjects
- Back Pain, Humans, Evidence-Based Medicine, Pain Management
- Abstract
Interventional pain medicine plays an important role in pain therapy for neck and back pain. However, spine interventions are characterized by controversy between its proponents and its detractors. Detractors variously assert that the procedures practiced lack validity, are not effective, or produce complications that impugn the procedures. The Spine Intervention Society (SIS) published several articles over the last decade that answer and refute these criticisms.
- Published
- 2020
- Full Text
- View/download PDF
39. [Pain and epilepsy : A clinical, neuroanatomical and pathophysiological review].
- Author
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Martin P
- Subjects
- Headache, Humans, Epilepsy, Migraine Disorders
- Abstract
Besides postictal headaches, epileptic seizures are infrequently associated with pain experiences. Nevertheless, seizure-associated pain is an important clinical symptom to recognize, diagnose and to differentiate from non-epileptic disorders. Seizure-associated pain may shed light on the anatomical and pathophysiological foundation of pain in general. According to its localization seizure-related pain is classified as unilateral somatosensory, abdominal and cephalic epileptic pain and according to its temporal relationship as ictal, peri-ictal, and interictal pain. Different aspects of pain phenomena in the context of epileptic seizures will be addressed by following these systematic classifications. In relation to seizures with unilateral somatosensory manifestation the functional anatomical context is described while differential diagnostic aspects in association with abdominal epilepsies are emphasized and terminological points as well as genetic epidemiological interrelationships between epilepsy and migraine are highlighted.
- Published
- 2018
- Full Text
- View/download PDF
40. [Clinical updates on phantom limb pain : German version].
- Author
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Erlenwein J, Diers M, Ernst J, Schulz F, and Petzke F
- Subjects
- Humans, Amputation Stumps, Amputation, Surgical, Pain, Postoperative prevention & control, Analgesics, Phantom Limb diagnosis, Phantom Limb therapy
- Abstract
Introduction: Most patients with amputation (up to 80 %) suffer from phantom limb pain postsurgery. These are often multimorbid patients who also have multiple risk factors for the development of chronic pain from a pain medicine perspective. Surgical removal of the body part and sectioning of peripheral nerves result in a lack of afferent feedback, followed by neuroplastic changes in the sensorimotor cortex. The experience of severe pain, peripheral, spinal, and cortical sensitization mechanisms, and changes in the body scheme contribute to chronic phantom limb pain. Psychosocial factors may also affect the course and the severity of the pain. Modern amputation medicine is an interdisciplinary responsibility., Methods: This review aims to provide an interdisciplinary overview of recent evidence-based and clinical knowledge., Results: The scientific evidence for best practice is weak and contrasted by various clinical reports describing the polypragmatic use of drugs and interventional techniques. Approaches to restore the body scheme and integration of sensorimotor input are of importance. Modern techniques, including apps and virtual reality, offer an exciting supplement to already established approaches based on mirror therapy. Targeted prosthesis care helps to obtain or restore limb function and at the same time plays an important role reshaping the body scheme., Discussion: Consequent prevention and treatment of severe postoperative pain and early integration of pharmacological and nonpharmacological interventions are required to reduce severe phantom limb pain. To obtain or restore body function, foresighted surgical planning and technique as well as an appropriate interdisciplinary management is needed., (© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2023
- Full Text
- View/download PDF
41. Kreuzreaktionen zwischen den Giften von Hymenopteren unterschiedlicher Familien, Gattungen und Arten
- Author
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Hemmer, W.
- Published
- 2014
- Full Text
- View/download PDF
42. Problemfälle der In-vitro-Diagnostik bei Hymenopterengiftallergie
- Author
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Müller, S., Rafei-Shamsabadi, D., and Jakob, T.
- Published
- 2014
- Full Text
- View/download PDF
43. E-Learning in der Orthopädie und Unfallchirurgie: Eine vergleichende Pilotstudie zur Akzeptanz und zum Wissenszuwachs unter Nutzern und Nichtnutzern
- Author
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Hoff, E., Haberstroh, N., Sostmann, K., Perka, C., Putzier, M., Schmidmaier, G., and Back, D.A.
- Published
- 2014
- Full Text
- View/download PDF
44. Psychologie der Kommunikation
- Author
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Jessica Röhner, Astrid Schütz, Jessica Röhner, and Astrid Schütz
- Subjects
- Communication--Psychological aspects
- Abstract
Dieses erfolgreiche Lehrbuch über die Psychologie der Kommunikation erklärt - hier in der dritten aktualisierten sowie überarbeiteten Auflage - alltagsnah und sehr verständlich, wie menschliche Kommunikation funktioniert. Es beginnt mit der Erläuterung zentraler Begriffe und der Erklärung bekannter Kommunikationsmodelle (bspw. die Modelle nach Schulz von Thun, Watzlawick sowie Hargie und Kollegen), beschreibt anschließend Mittel nonverbaler sowie verbaler Kommunikation und endet mit einer übersichtlichen und strukturierten Zusammenfassung von Kommunikationsformen. Konkrete Anwendungsfelder, Stolpersteine (z. B. interkulturelle Unterschiede in der Kommunikation), praktische Beispiele und Exkurse im Buch runden das Gelesene ab und festigen das Gelernte. Zudem stehen kostenlose Lernmaterialien im Internet bereit, mit denen Lesende ihren Wissenserwerb überprüfen können.Dr. Jessica Röhner ist Stipendiatin und Habilitandin am Lehrstuhl für Persönlichkeitspsychologie und Diagnostik an der Otto-Friedrich-Universität Bamberg.Prof. Dr. Astrid Schütz ist Inhaberin des Lehrstuhls für Persönlichkeitspsychologie und Leiterin des Kompetenzzentrums für Angewandte Personalpsychologie an der Otto-Friedrich-Universität Bamberg sowie zertifizierte Coachin.
- Published
- 2020
45. Testtheorie und Fragebogenkonstruktion
- Author
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Helfried Moosbrugger, Augustin Kelava, Helfried Moosbrugger, and Augustin Kelava
- Subjects
- Psychological tests, Psychology, Statistics, Psychometrics
- Abstract
Dieses Standard-Lehrbuch deckt das gesamte Themenfeld der Testtheorie und Fragebogenkonstruktion ab - von den Grundlagen im Bachelor-Studium bis zu vertiefenden Aspekten in Master-Studiengängen. Neben dem unverzichtbaren Prüfungswissen fürs Studium liefert es auch Fortgeschrittenen der psychologischen Diagnostik fundiertes Handwerkszeug für Forschungspraxis und Berufsalltag - von der Diagnostik im klinischen Setting bis hin zu Fragen des Assessments im Berufsleben. Die neue Auflage wurde grundlegend überarbeitet, aktualisiert und erweitert.Univ.-Prof. Dr. Helfried Moosbrugger, Lehrstuhl für Forschungsmethoden und Evaluation an der Goethe-Universität Frankfurt, Emeritus und Seniorprofessor; zahlreiche Methodenlehrbücher, Testentwicklungen und internationale Veröffentlichungen, langjähriger Vorsitzender der Fachgruppe Methoden und Evaluation (DGPs) sowie des Testkuratoriums der Föderation Deutscher Psychologenvereinigungen (DGPs und BDP) zur Qualitätssicherung von Testverfahren und ihren Anwendungen.Univ.-Prof. Dr. Augustin Kelava, Gründungsdirektor des Instituts Methodenzentrum in der Wirtschafts- und Sozialwissenschaftlichen Fakultät der Eberhard Karls Universität Tübingen und verantwortlich für den Bereich quantitative Methoden, zahlreiche internationale Publikationen im Bereich der Entwicklung latenter Variablenmodelle (Schätzverfahren, Modellklassen), breite Anwendungsfelder (z. B. Studienabbruchsforschung, Studierendenauswahl, Emotionsregulation), diverse wissenschaftliche Beirats-, Gutachter- und Kommissionstätigkeiten.
- Published
- 2020
46. [Pain management in German specialized outpatient palliative care : A cross-sectional study to present the current pain management of palliative patients in the home environment].
- Author
-
Volberg C, Corzilius J, Maul J, Morin A, and Gschnell M
- Abstract
Background: With the help of specialized outpatient palliative care teams (German abbreviation: SAPV), seriously ill and dying patients in Germany can be adequately cared for in their home environment until the end of their lives; however, there are no uniform standards or guidelines for well-executed pain management right now., Objective: This approach serves as basic research in the field of public health research. This is intended to present which methods (use of different professional groups, use of pain medications, alternative medical treatment etc.) the individual SAPV teams use for pain management. From this it can be deduced which procedures can be considered particularly effective., Material and Methods: This cross-sectional study was conducted in May 2021. All German SAPV teams (n = 307) listed on the homepage of the German Association for Palliative Medicine (DGP) were contacted by post and invited to participate. A total of 175 teams (57%) responded to the request and were included in the evaluation. A descriptive data analysis was performed., Results: Pain management in the German outpatient care of palliative patients is based on several components. All common pain medications are used, but primarily metamizole (99.4%) as a non-opioid analgesic, morphine (98.3%) from the opiate series and pregabalin (96.6%) as a co-analgesic are mainly prescribed. If pain therapy fails, 22.5% of the SAPV teams perform palliative sedation for symptom control on a regular basis., Conclusion: This cross-sectional study is the first of its kind to provide a general overview of the treatment options for pain management in German outpatient palliative care. In comparison with international studies, the question arises as to whether uniform therapy schemes and a reduction in the medication available in the individual SAPV teams could lead to an improvement in patient care., (© 2023. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
47. [Benefits and harms of cannabis-based medicines from the viewpoint of patients with chronic pain and their physicians : A cohort study in three pain centers of the German federal state Saarland].
- Author
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Böttge-Wolpers C, Bialas P, Gottschling S, Juckenhöfel S, Konietzke D, Madlinger A, Welsch P, and Häuser W
- Abstract
Background: There are no studies available that have simultaneously assessed the benefits and harms of cannabis-based medicines from the viewpoint of patients and their physicians., Methods: All chronic pain patients at three pain centres in the German federal state of Saarland who had received at least one prescription of cannabis-based medicines (CbMs) in the past from the study centre were included in a cross-sectional study from January 1 to December 31, 2021. Patients and their physicians completed a self-developed questionnaire separately., Results: All 187 contacted patients participated in the study. Since the start of CbM therapy, 44.9% of patients reported to be much or very much, 43.3% to be moderately and 8.0% to be slightly improved overall. A total of 2.7% reported no change and 1.1% a moderate deterioration of overall wellbeing. From the patients' point of view, the symptoms most frequently reported to have substantially improved were sleep problems (36.4%), muscle tension (25.1%) and appetite problems (22.1%). The most frequent bothersome side effects were sweating (6.4%), concentration problems (4.2%) and nausea (4.1%). Physicians noted substantial pain relief in 60.7%, improvement of sleep in 65.7% and of mental well-being in 34.3%. A complete cessation of opioids was achieved in 64.7%, of anticonvulsants in 57.9% and of antidepressants in 60% of patients that had received these medications before the start of CbM therapy., Conclusions: CbMs can contribute to a clinically relevant reduction in pain, sleep problems and muscle tension and can improve daily functioning in carefully selected and supervised patients with chronic pain. CbM can contribute to the reduction or complete cessation of other pain medications (antidepressants, anticonvulsants, opioids)., (© 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2023
- Full Text
- View/download PDF
48. Therapie der Prurigo nodularis
- Author
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Zeidler, C. and Ständer, S.
- Published
- 2014
- Full Text
- View/download PDF
49. Wichtige, durch Vektoren übertragene Infektionskrankheiten beim Menschen in Deutschland: Epidemiologische Aspekte
- Author
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Frank, C., Faber, M., Hellenbrand, W., Wilking, H., and Stark, K.
- Published
- 2014
- Full Text
- View/download PDF
50. [Sarcoidosis and berylliosis].
- Author
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Soriano D, Quartucci C, Agarwal P, Müller-Quernheim J, and Frye BC
- Subjects
- Beryllium, Granuloma complications, Humans, Lung, Berylliosis diagnosis, Berylliosis etiology, Berylliosis therapy, Sarcoidosis complications, Sarcoidosis diagnosis
- Abstract
Sarcoidosis and berylliosis (chronic beryllium disease, CBD) are granulomatous diseases and are phenocopies which cannot be differentiated based on the clinical presentation. Whereas for sarcoidosis the eliciting agent is unknown, for berylliosis an exposure to beryllium (mostly as occupational exposure) can be confirmed that therefore induces a sensitization against beryllium. The diagnosis is generally made in patients with a typical clinical presentation, the histological proof of a non-necrotizing granuloma and the exclusion of other diseases causing granulomas. In most cases, granulomas can be detected in the lungs and/or (intrathoracic) lymph nodes. The proof of sensitization to beryllium for the differential diagnosis can be performed with a so-called beryllium lymphocyte proliferation test in peripheral mononuclear blood cells or cells from a bronchoalveolar lavage. The objectives of treatment are avoidance of functional organ impairment and symptom control. Immunosuppressive therapy (initially mostly with corticosteroids) and supportive measures can prove beneficial; however, in many cases clinical observation can be sufficient because of stable disease or spontaneous resolution. In addition, further beryllium exposure must be avoided, which mostly necessitates a change of the workplace., (© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2022
- Full Text
- View/download PDF
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