1. Le suivi à long terme après traitement d'une leucémie aiguë de l'enfant : enjeux, acquis et perspectives.
- Author
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Michel, Gérard and Tabone, Marie-Dominique
- Subjects
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ACUTE leukemia , *LEUKEMIA in children , *ANTHRACYCLINES , *CANCER patients , *QUALITY of life - Abstract
The number of childhood leukemia survivors increases. Many of them do not have any late effects and enjoy normal life. Others suffer from physical late complications or psychological, social and professional difficulties. The most common therapeutic risk factors for physical late effects are anthracycline, high-dose alkylating agents, brain irradiation and hematopoietic stem cell transplantation, notably after a total body irradiation-containing conditioning regimen. Inter-individual variability of late effects occurrence suggests that genetic susceptibility may play a role. The main late effects after leukemia treatment are endocrine (growth, gonadal function, fertility, and thyroid), nutritional (metabolic syndrome), cardiac, bone disorders and second malignancies. Interaction between physical late effects and quality of life are complex. [ABSTRACT FROM AUTHOR] more...
- Published
- 2019
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