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La schizophrénie est considérée comme l'un des troubles psychiatriques les plus invalidants. L'une des principales raisons de ce fardeau élevé est qu'une grande partie des patients atteints de schizophrénie ne répondent pas adéquatement aux traitements pharmacologiques de première ligne et continueront de souffrir d’hallucinations auditives. La présence de celles-ci peut avoir un effet dévastateur sur le bien-être émotionnel des patients ainsi que sur leur qualité de vie. Les alternatives non-pharmacologiques (ex., Thérapie cognitivo-comportementale (TCC)) demeurent aussi limitées. Ainsi, pour plusieurs patients, les traitements actuellement recommandés ne sont pas suffisants. À cet égard, le traitement de la schizophrénie peut être perfectionné si, en plus du traitement des symptômes, l'accent thérapeutique est mis sur d’autres sphères importantes pour les patients (ex., améliorer l’estime de soi, réguler les émotions). Les efforts visant à accroître l'efficacité et les bénéfices des psychothérapies fondées sur des preuves ont mené à l'émergence d'interventions basées sur la réalité virtuelle (RV). Avec ces progrès technologiques, AVATAR Therapy et l’adaptation faite par notre équipe, la Thérapie assistée par la Réalité Virtuelle (TRV) (ou communément nommé la Thérapie Avatar (TA)), permettent aux patients d’entrer en dialogue en temps réel avec un avatar, animé entièrement par le thérapeute, qui représente leur voix la plus persécutrice. Cette approche, à la fois relationnelle et expérientielle, offre une occasion unique d’aider les patients à prendre le contrôle de leur voix. Cette thèse a pour objectif principal d’évaluer l’efficacité de cette psychothérapie basée sur la RV ainsi que les thèmes abordés durant et après la thérapie. Pour arriver à cette fin, divers objectifs ont été mis à l’avant : (i) résumer l'état des preuves sur l'efficacité des interventions basées sur la RV pour les troubles psychiatriques, (ii) évaluer l'efficacité de la TA/TRV par rapport à la TCC, (iii) illustrer l’efficacité de la thérapie à travers la perspective de patients ayant montré des effets bénéfiques, et (iv) explorer les thèmes émergeants ainsi que les processus thérapeutiques de la TA/TRV. Dans la première section, deux recensions des écritsdans diverses bases de données ont été effectuées pour examiner l’efficacité des psychothérapies basées sur la RV. Notre méta-revue (c’est-à-dire revue de méta-analyse) incluant 11 méta-analyses et 41 tailles d'effet a montré des résultats positifs de la RV dans le traitement des troubles psychiatriques, principalement des troubles anxieux. Les interventions basées sur la RV sont meilleures que le traitement usuel et montrent généralement des effets similaires par rapport aux approches fondées sur des preuves. Les résultats préliminaires suggèrent également que les effets de la RV se maintiennent dans le temps. Par contre, de nombreux symptômes et troubles psychiatriques qui peuvent être traités par des interventions utilisant RV n'ont pu être examinés par une analyse méta-analytique, en particulier les symptômes psychotiques (ex., hallucinations auditives) et les comportements liés à l'agressivité (ex., régulation émotionnelle). Ainsi, notre seconde revue a montré qu’il existe un nombre limité de paradigmes basés sur la RV pour traiter les individus atteints de troubles psychotiques et autres troubles mentaux à risque de comportements agressifs. Les études préliminaires dans des populations autres que la schizophrénie ont montré des réductions de la colère et de l'impulsivité, des améliorations des capacités de résolution des conflits ainsi que des niveaux d'empathie et des diminutions de l'agressivité. En ce qui a trait aux interventions basées sur la RV pour la schizophrénie, des réductions par rapport aux délires et aux hallucinations auditives ont été trouvées. Dans la seconde section, deux essais cliniques ont été menés pour évaluer l’efficacité de la TA/TRV seule en comparaison avec la TCC et en combinaison avec la TCC (TCC+TA/TRV). Notre essai randomisé comparant la TA/TRV à la TCC a compris 37 participants de plus de 18 ans entendant des voix persécutives et souffrant de schizophrénie résistante aux traitements dans chacun des groupes. Les résultats principaux ont montré que les deux interventions ont produit des améliorations significatives sur la sévérité des symptômes hallucinatoires avec des effets plus prononcés pour la TA/TRV. De plus, les résultats suggèrent une supériorité de la TA/TRV par rapport à la TCC sur les symptômes affectifs. La TA/TRV a également montré des effets positifs sur la qualité de vie. Les effets ont été maintenus à long terme, soit jusqu'à un an de suivi. Notre preuve de concept sur 10 patients ayant suivi la TCC de notre essai clinique comparatif qui souhaitaient continuer à obtenir des améliorations avec la TA/TRV a montré que les effets de la TCC+TA/TRV sur les symptômes dépressifs et les symptômes de la schizophrénie étaient plus larges que ceux trouvés pour l'une ou l'autre des interventions uniques. La troisième section a pour but de détailler les cas de 2 patients ayant suivi la TA/TRV. D’abord, nous avons décrit un partenariat entre un utilisateur de services en santé mentale et des chercheurs cliniciens en mettant en vedette M. X, le premier patient à suivre la thérapie. Nous avons ainsi montré l’apport de monsieur X quant à ses suggestions d’amélioration de la thérapie et ensuite en tant que notre pair aidant pour les futurs patients, dans son cheminement vers le rétablissement. Ensuite, nous avions rapporté le cas d'un patient atteint d’une schizophrénie ultra-résistante, soit M. Smith, qui n'a pas répondu à plusieurs traitements antipsychotiques, à la stimulation magnétique transcrânienne répétitive et à la thérapie par électrochocs avant de participer à notre essai. De plus, le patient a terminé notre TCC avant de se voir proposer notre TA/TRV. Cette dernière intervention a montré les effets les plus positifs. Or, ces deux cas ont montré que la thérapie a aidé non seulement à diminuer leurs symptômes, mais aussi à améliorer leur qualité de vie. La quatrième section a pour objectif d’explorer les thèmes émergents de la TA/TRV suite à des analyses de contenu. Ainsi, suite à une analyse qualitative découlant du discours spontané de 10 patients ayant bien répondu à la TA/TRV, quatre thèmes généraux ont émergé : impact de la thérapie sur les voix, relations interpersonnelles, bien-être psychologique et mode de vie. Cette analyse de contenu a permis d’identifier plusieurs sphères de vie qui sont davantage améliorées chez les patients ayant une schizophrénie résistante aux traitements à l’aide de la TA/TRV. Deux autres analyses qualitatives ont été conduites pour approfondir nos connaissances sur les processus thérapeutiques de la TA/TRV. Celles-ci ont permis de montrer que les patients répondent au propos de l’avatar en utilisant des mécanismes d'adaptation ou en exprimant des émotions, des croyances, des perceptions de soi ou des aspirations. Le discours de l'avatar a pu être catégorisé en techniques de confrontation (ex., provocation) et en techniques positives (ex., renforcement). Grâce à l'identification de changements mutuels dans l'interaction entre le patient et son avatar, un changement a été observé au fil des séances de la confrontation vers un dialogue constructif. L'affirmation de soi, les réponses émotionnelles et les stratégies de prévention semblaient être au cœur du processus thérapeutique, et celles-ci se produisent généralement en réponse à des techniques positives. Cette thèse contribue à la validation d’une nouvelle approche thérapeutique répondant à un besoin clinique fondamental. Ainsi, la TA/TRV met en lumière l'avenir des approches adaptées aux patients qui peuvent présenter des avantages par rapport aux traitements conventionnels. Ces types d’interventions holistiques utilisant la RV pourraient aussi présenter des avenues prometteuses dans plusieurs autres troubles psychiatriques., Schizophrenia is considered one of the most debilitating psychiatric disorders. One of the main reasons for this high burden is that a large proportion of patients with schizophrenia do not respond adequately to first-line pharmacological treatments and will continue to suffer from auditory hallucinations. The presence of these symptoms can have a devastating effect on the emotional well-being of patients as well as their quality of life. Non-pharmacological alternatives (e.g., Cognitive Behavioral Therapy (CBT)) also remain limited. Thus, for many patients, the treatments currently recommended are not sufficient. In this regard, the treatment of schizophrenia may be improved if, in addition to the treatment of symptoms, therapeutic emphasis is placed on other areas of importance to patients (e.g., improving self-esteem, emotion regulation). Efforts to increase the effectiveness and benefits of evidence-based psychotherapies have led to the emergence of virtual reality (VR)-based interventions. With these technological advances, AVATAR Therapy and its related innovative form from our team, Virtual Reality Assisted Therapy (VRT) (or commonly Avatar Therapy (AT)), allow patients to enter a real-time dialogue with an avatar, animated entirely by the therapist, who represents their most persecutory voice. This approach, both relational and experiential, offers a unique opportunity to help patients take control of their voice. The main objective of this thesis is to evaluate the effectiveness of this psychotherapy based on VR as well as the themes addressed during and after the therapy. To achieve this end, various objectives have been put forward: (i) summarize the state of the evidence on the effectiveness of VR-based interventions for psychiatric disorders, (ii) assess the effectiveness of AT/VRT versus CBT, (iii) obtain the perspective of patients who have undergone AT/TRV, (iv) explore the therapeutic processes of AT/VRT. In the first section, two literature reviews in various databases were performed to examine the effectiveness of VR-based psychotherapies. Our meta-review including 11 meta-analyzes and 41 effect sizes showed positive results of VR in the treatment of psychiatric disorders, mainly anxiety disorders. VR-based interventions appear better than inactive controls and generally show similar effects compared to evidence-based approaches. Preliminary results also suggest that the effects of VR are sustained over time. On the other hand, many psychiatric symptoms and disorders that can be treated with interventions using VR have not been examined by a meta-analytical analysis, including psychotic symptoms (e.g., auditory hallucinations) and related behaviors. aggression (e.g., emotional regulation). Thus, our second review showed that there are a limited number of VR-based paradigms for treating individuals with psychotic disorders and other mental disorders at risk for aggressive behavior. Preliminary studies in populations other than schizophrenia have shown reductions in anger and impulsivity, improvements in conflict resolution skills as well as levels of empathy and decreases in aggression. Particularly related to VR interventions for schizophrenia, reductions in delusions and auditory hallucinations were found. In the second section, two clinical trials were conducted to evaluate the efficacy of AT/VRT alone in comparison with CBT and in combination with CBT (CBT+TA/VRT). Our randomized trial comparing AT/VRT to CBT included 37 participants over 18 years of age hearing persecutory voices and suffering from treatment-resistant schizophrenia in each group. The main results showed that the two interventions produced significant improvements in the severity of hallucinatory symptoms with more pronounced effects for AT/VRT. In addition, the results suggest that AT/VRT is superior to CBT on affective symptoms. AT/VRT has also shown positive effects on quality of life. The effects were maintained for up to one year of follow-up. Our proof of concept on 10 patients having followed CBT from our comparative clinical trial who wanted to continue to achieve improvements with AT/VRT showed that the effects of CBT+AT/VRT on depressive symptoms and symptoms of schizophrenia were broader than those found for either intervention alone. The third section details the cases of 2 patients who had followed AT/VRT. First, we described a partnership between a mental health service user and clinical researchers by featuring Mr. X, the first to follow therapy for his suggestions and our peer helper for future patients, on his journey to the recovery. Next, we reported the case of a patient with ultra-resistant schizophrenia, Mr. Smith, who failed to respond to multiple antipsychotic treatments, repetitive transcranial magnetic stimulation, and electroconvulsive therapy before participating in our trial. In addition, this patient completed our CBT before being offered AT/VRT. The latter intervention showed the most positive effects. These two cases showed that AT/VRT not only helped to decrease their symptoms, but also to improve their quality of life. The fourth section aimed to explore emerging themes of AT/VRT following content analyses. Thus, following a qualitative analysis resulting from the spontaneous speech of 10 patients who responded well to AT/VRT, four general themes emerged: impact of therapy on voices, interpersonal relationships, psychological well-being and lifestyle. This content analysis identified several areas of life that are further improved in patients with treatment resistant schizophrenia after having followed AT/VRT. Two other qualitative analyses were carried out to deepen our knowledge of the therapeutic processes of AT/VRT. These have shown that patients respond to the avatar's words by using a coping mechanism or by expressing emotions, beliefs, self-perceptions or aspirations. The avatar's discourse could be categorized into confrontational techniques (e.g., provocation) and positive techniques (e.g., reinforcement). With the identification of mutual changes in the interaction between the patient and their avatar, a shift was observed over therapy sessions from confrontation towards a constructive dialogue. Assertiveness, emotional responses, and prevention strategies seemed to be central to the therapeutic process, and these usually occurred in response to positive techniques. This thesis contributes to the validation of a new therapeutic approach responding to a fundamental clinical need. Thus, AT/VRT shines a light on the future of patient-oriented approaches that may have advantages over conventional treatments. These types of holistic interventions using VR may have notable applications in several other psychiatric disorders.

Objectives Anxiety and depression are the most prevalent disorders observed in health care services and are frequently comorbid with other disorders. Although Cognitive-Behavioral Therapy (CBT) has widely been shown efficacious to treat anxiety and mood disorders, studies that have focused on its effectiveness in the presence of comorbidity have been few and show conflicting results. Thus, the implications of the presence of comorbid disorders for treatment are still unknown. In an attempt to answer these questions, this study explores the impact of comorbidity on CBT for anxiety and mood disorders in a university-based clinic. Methods A total of 293 clients consulting for anxiety and/or mood disorders at the Service de Consultation de l'École de Psychologie de l'Université Laval (SCEP) between 2007 and 2018 took part in the study. Clients were excluded if they presented uncontrolled psychotic, manic or substance abuse symptoms as their principal complaint. Clients without comorbid disorders where compared to clients who had comorbid disorders on different measures before and after receiving therapy to examine if comorbidity had an impact on CBT effectiveness to treat the principal disorder. The impact of treatment on comorbid disorders was also investigated. Effectiveness was assessed on several measures before and after treatment including the severity of diagnoses (measured with a structured interview), anxiety and mood symptoms as well as quality of life. Repeated measures ANOVAs and t-tests were used. Results Before initiating therapy, clients with comorbid disorders had significantly more severe symptoms than clients without comorbid disorders. However, following therapy, both groups had significantly less severe principal disorders and reached a clinically significant change in equivalent proportions. Furthermore, the number and severity of comorbid disorders significantly decreased following therapy. Conclusion These findings suggest that although the presence of comorbid disorders leads to more severe symptoms, it does not affect the effectiveness of CBT for the principal disorder. Furthermore, comorbid disorders improved even though they were not specifically targeted by treatment. In concordance with the literature, it is thus suggested to keep focusing treatment on the principal disorder, whether comorbid disorders are present or not.

Introduction Socio-professional reintegration is an objective that is regularly sought-after by people in the early stages of a psychotic disorder. Despite this, employment rates are low for this population and high school dropout rates remind at a high level. Objectives and method This literature synthesis based on recent meta-analyses and studies aims at presenting the determinants of vocational and school integration for people in the early stages of a psychotic disorder. This will be followed by the presentation of the most studied supported employment and education programs, as well as by complementary interventions to support existing programs. In addition, key concepts are illustrated through clinical vignettes for this clientele. Results. Several barriers to socio-professional reintegration in this population could help explain the lower success rates when compared to the general population, including individual factors (e.g., past employment history, length of absence from the labour market, negative and cognitive symptoms, motivation) and environmental factors (e.g., availability of supported employment or education programs, competence of the employment specialist, social assistance benefits, employer attitude). The program that shows the most accumulated evidence is called Individual Placement and Support (IPS) and is frequently used in Quebec. IPS focuses on competitive job search, rapid placement in the labour market and collaboration between an employment specialist, the client, and the employer. Mowbray's supported education programs, as well as IPS adapted for education, help respond more specifically to the needs of people in the early stages of a psychotic disorder, who often wish to return to school. This article describes two clinical examples of programs offered in Quebec. Despite the interesting results provided by supported programs, socio-professional reintegration and maintaining employment remain difficult for people who are in the early stages of a psychotic disorder. Considering this, several researchers suggest that interventions for people with psychotic disorders should be more individualized, given the great heterogeneity associated with this condition. Combining interventions that are specific to each candidate's pre-existing individual deficits (e.g., cognitive remediation, cognitive-behavioural therapy, social skills training) appears to be an effective solution for optimizing the therapeutic response in supported employment or education programs. Conclusion This article highlights the issues related to the professional or academic reintegration of people in the early stages of a psychotic disorder, in order to guide practitioners in the field and to offer possible solutions to the current limitations of these programs in Quebec, including access to certain interventions.

Objective Treatment guidelines for the treatment of psychotic disorders suggest evidence-based interventions. These interventions target several domains such as self-management of clinical symptoms, social, familial and love relationships as well as cognitive functioning. However, these general guidelines do not provide specific evidence for people with a first-episode psychosis (FEP). The objective of this narrative and critical review is to present evidence supporting the interventions suggested by the treatment guidelines that were validated in people with a FEP, particularly those interventions validated in French. Method Based on the international and national treatment guidelines, a narrative and critical review of the scientific literature conducted in people with FEP and focusing on two recommended interventions for psychotic disorders, cognitive-behavioral therapy for psychosis (CBTp) and cognitive remediation (CR), was performed. Administration modalities adapted to the participant's profile are important to consider in this type of intervention. We thus explored two promising modalities in people with FEP, the group format and the use of digital technologies. Results Several studies support the use of CBTp in people with FEP, including one Quebec study. The effects of CR are less promising in people with FEP compared to those with a chronic evolution of their psychotic illness (e.g. schizophrenia). However, some limitations of the included studies are identified and the specific improvements in people with FEP are presented. Regarding the group format and the digital technologies, most interventions currently available need to be systematically validated, and the results need to be replicated by other groups of researchers to obtain evidence-based results. Conclusion This narrative and critical review of the literature highlights the evidence available for CBTp and CR in people with FEP. The group format used in several interventions with this population reveals encouraging results, while interventions using digital technologies have shown their acceptability and feasibility, but the efficacy remains to be assessed. In addition to contributing to symptomatic recovery, psychosocial interventions also support functional and personal recovery in people with FEP. Nonetheless, some limitations are observed regarding the accessibility of such interventions. While some interventions are currently not available in French, other available evidence-based interventions are not currently systematically used in clinical settings. These limitations call for the importance of developing an implementation science for these interventions to improve the transfer of results from research to clinical settings as well as a service organization model that promote or facilitate access to such interventions.

National audience; Depression after an ischemic cerebrovascular accident is a frequent phenomenon that occurs in 30 to 50% of the patients. Depression negatively impacts stroke outcome with increased morbidity, poorer functional recovery and may aggravate mortality. Post-stroke depression diagnosis is made difficult by the motor and cognitive consequences of the stroke, but also by the overlap between depressive symptoms and some of the stroke symptoms. Several mechanisms are involved in its complex pathophysiology, including physiological reaction to the sudden handicap, but also psychological, biological (with monoamine hypothesis), inflammatory and anatomic dysfunctions. The treatment of choice must combine antidepressants (serotonin reuptake inhibitors) associated to cognitive behavioral psychotherapy. Cerebral neuromodulation techniques may also be used in this indication. © 2022 l'Académie nationale de médecineLa dépression après un accident vasculaire cérébral ischémique (AVCi) est un phénomène fréquent dont la prévalence est évaluée à 30 à 50% des cas. Elle a un impact direct sur les capacités de récupération fonctionnelles et de réhabilitation des patients souffrant d'un AVCi et peut aggraver la mortalité. Le diagnostic de cette dépression est rendu difficile par les conséquences motrices et cognitives de l'AVCi, mais aussi par la superposition des symptômes de l'AVCi et de la dépression. Sa physiopathologie est complexe, comprenant les éléments de réaction physiologique au handicap brutal à des mécanismes monoaminergiques, inflammatoires et anatomiques. Sa prise en charge doit associer des éléments de psychothérapie cognitivo-comportementale et la prescription d'antidépresseurs. © 2022 l'Académie nationale de médecine

Objectives Despite the existence of several online treatments for people with posttraumatic stress disorder (PTSD), few studies have examined usage data for such interventions. Given the potential of the online modality to alleviate barriers limiting access to psychological help, it is important to document users' interactions with these tools in relation to the improvement of targeted symptoms. The objective of this study is to document usage data of the online treatment platform RESILIENT by people evacuated from the Fort McMurray, Alberta (Canada) fires, and to examine their association with the effectiveness of treatment on symptoms of posttraumatic stress disorder (PTSD), insomnia and depression, and adherence to treatment, as measured by the number of modules accessed by participants. Methods Ninety-seven people evacuated from the Fort McMurray fires with symptoms of PTSD, insomnia and depression were included in this study. Participants were invited to use the RESILIENT platform, an online therapist-assisted self-help treatment program that targets PTSD symptoms, sleep and mood, and includes 12 modules offering evidence-based cognitive-behavioural therapy (CBT) strategies. Both objective (e.g., number of modules accessed) and subjective (e.g., level of effort invested) usage data were collected. Results In order to predict the reduction in PTSD, depression and insomnia symptoms, as well as the number of modules accessed by participants, sequential regression models were conducted, with statistical control for pretreatment symptoms, age and gender. The final models revealed that a reduction in PTSD, depression and insomnia symptoms was significantly predicted by the number of modules accessed (β = -.41; -.53; -.49 respectively, all p.001) as well as the mean self-reported level of effort at module 7 (midway) (β = -.43; p.001; β = -.38; p = .005 and β = -.36; p = .007 respectively). The number of modules accessed, on the other hand, was significantly predicted by the number of words in the 4th module (β = .34; p.001) and 7th module (β = .44; p.001) and the number of sleep diary entries (β = .28; p.001). Conclusion These results confirmed that increased interaction with the platform positively influences treatment effectiveness and that increased use at the beginning of treatment appears to be a good predictor of treatment completion. This study confirms the importance of sustaining participants' commitment to online treatment in order to optimize its effectiveness.

Decentration and cognitive restructuring are used in cognitive-behavioural therapy (CBT) with patients suffering from chronic pain and are reinforced by group work. They can also be useful to the general practitioner. Clinical vignettes summarize the role of group CBT in identifying realistic and meaningful activities. They stress decentration and cognitive restructuring as key therapeutic tools in group CBT. Using them with patients suffering from chronic pain is complex and challenging when it comes to allow the patients to overcome the impossibility to function 'as before' while figuring out how to cope 'as for now'.La décentration et la restructuration cognitive sont utilisées dans les thérapies cognitivocomportementales (TCC) chez les patients souffrant de douleurs chroniques et sont renforcées par le travail en groupe. Elles peuvent également être utilisées par les praticiens dans leurs cabinets. Des vignettes cliniques résument leur rôle dans l’identification d’activités réalistes et significatives et posent la décentration et la restructuration cognitive en tant qu’outils d’intérêt pour la TCC de groupe. Leur utilisation avec des patients douloureux chroniques peut permettre aux patients de surmonter l’impossibilité à faire « comme avant » pour s’imaginer parvenir à gérer « comme maintenant ».

Confronted with a complaint of insomnia, several points must be considered before prescribing a specific treatment. In particular, it is necessary to optimize the management of somatic and psychiatric comorbidities that can affect sleep and to review the intake of sleep-disrupting substances and drugs. The current guidelines for insomnia rank treatment options based on the quality of the evidence. They all agree to recommend cognitive behavioural therapy for insomnia as first-line treatment. Pharmacological treatment should only be considered if this therapy fails. We then propose to start with the drugs presenting the best safety profile before prescribing, if necessary, those having better effectiveness evidence but carrying a greater risk of side effects.

Confronted with a complaint of insomnia, several points must be considered before prescribing a specific treatment. In particular, it is necessary to optimize the management of somatic and psychiatric comorbidities that can affect sleep and to review the intake of sleep-disrupting substances and drugs. The current guidelines for insomnia rank treatment options based on the quality of the evidence. They all agree to recommend cognitive behavioural therapy for insomnia as first-line treatment. Pharmacological treatment should only be considered if this therapy fails. We then propose to start with the drugs presenting the best safety profile before prescribing, if necessary, those having better effectiveness evidence but carrying a greater risk of side effects.Face à une plainte d’insomnie, plusieurs points sont à prendre en compte avant d’envisager un traitement spécifique, notamment l’optimisation de la prise en charge des comorbidités somatiques et psychiatriques pouvant péjorer le sommeil et la revue de la prise de substances et médicaments le perturbant. Les recommandations sur l’insomnie classent les options thérapeutiques selon la qualité des études à disposition. Elles s’accordent toutes à recommander la thérapie cognitivo-comportementale spécifique pour l’insomnie en première intention. Un traitement pharmacologique ne devrait être envisagé qu’en cas d’échec de cette thérapie. Nous proposons alors de débuter avec les molécules présentant le meilleur profil de sécurité avant de passer, si nécessaire, à celles ayant mieux démontré leur efficacité mais comportant un plus grand risque d’effets secondaires.

Fatigue is a frequent and disturbing symptom in oncology but remains undertreated. Given the absence of effective drug treatment, non-pharmacological interventions have a prominent place in the treatment of fatigue. However, they are relatively unknown by professionals who lack of clear points of reference to refer patients with confidence. This article aims to improve the knowledge about this therapeutic field through an updated synthesis of the levels of recommendations and available evidence.A three-step approach was conducted, including (1) a synthesis of international guidelines on non-pharmacological interventions in the treatment of fatigue among adults in oncology, (2) a systematic review of recent data in the literature, (3) a comparison between the synthesis of guidelines and the systematic review with the aim of updating the levels of evidence.Five guidelines were synthesized; 111 systematic reviews were analyzed. Their comparison mainly showed: (1) a convergence in favor of the use of physical activity, educational interventions and cognitive-behavioral therapies, with levels of evidence ranging from moderate to high; (2) a consolidation of short-term efficacy evidence to support the use of mindfulness-based approaches and yoga; 3) the persistence of a lack of sufficiently reliable data to establish the efficacy of other types of intervention.Supported by international guidelines and recent data, the use of non-pharmacological interventions in the treatment of fatigue is critical and has to become better known.

The Pavillon Albert-Prévost (PAP) has played a leading role in the development of modern psychiatry in the province of Québec. It has also been, in the francophone milieu, the teaching hospital that was the most deeply influenced by psychoanalytic theories. The arrival of somatic approaches, particularly biofeedback and relaxation, in the Psychosomatic medicine and consultation-liaison service, as introduced by Dr. Jacques Monday in the 1970s, was initially greeted with great scepticism by the majority of his colleagues at PAP. In the 1980s and 1990s, Dr. Camille Laurin, then head of the department, invited Dr. Louis Chaloult to offer a clinical supervision seminar to mental health professionals. Drs. Chaloult and Monday trained generations of clinicians in cognitive behavior therapy and relaxation therapy as, over time, these approaches both practical, efficient and effective became more widely practiced and recommended by practice guidelines in psychiatry. Dr. Chaloult with the help of Dr. Jean Goulet developed a CBT teaching curriculum for residents in psychiatry and other health care professionals, wrote an influential textbook on CBT, co-developped a widely consulted website www.tccmontreal.com providing CBT practice guides for clinicians and patients alike, became one of the first psychiatrists acting as a psychiatre répondant in CLSCs (teaching CBT to other members of the team in order to provide CBT in primary care), co-developed the Centre de Psychothérapie at the PAP to promote cross theoretical training in psychotherapy for residents in psychiatry and interns of other mental healthcare disciplines. In this spirit, Dre. Thanh-Lan Ngô contributed to these endeavors and co-created with Dr. Jean Leblanc and Dre. Magalie Lussier-Valade another website www.psychopap.com dedicated to the transfer of knowledge in CBT as well as other forms of psychotherapy in order to celebrate 100 years of teaching in psychiatry at the PAP. Following the creation of specialised outpatient clinics in 1994, CBT was more widely offered and developed as a standard of care. These influential programs include those of three psychologists Dr Michel Dugas' Generalised anxiety disorder model, Pascale Brillon's teaching of trauma focussed CBT (with three books on the subject, Dr Richard Fleet's research on emergency room presentation of panic disorder. This collaborative teaching and research program included Dre. Julie Turcotte and Dr. Pierre Savard, both specialised in CBT and instrumental in training generations of psychiatrists in evidence-based treatments for severe refractory disorders. At the Early psychosis clinic, an innovative program of CBT modules adapted to the functional and symptomatic impairment level of the heterogeneous clientele was developed by Pierre Fortier and Dr. Jean-Pierre Mottard. At the Readaptation for Psychosis program, France Bérubé and Jocelyne St-Onge, offered auditory hallucinations group, metacognitive therapy, the integrated psychotherapy programme. At the Personality disorder clinic, dialectical behavior therapy groups were offered by Julie Jomphe who trained many cohorts of residents, offered adaptations to families (Family connections), adolescents, and children (in schools). At the Psychosomatic service Donald Bouthillier treated somatisation disorders with affective-cognitive behavioral therapy for somatization disorder. And finally, at the Mood disorder clinic, Drs. Ngô, Bernard Gauthier, Léon Maurice Larouche, Anne-Sophie Boulanger along with Manon Quesnel, Renée Leblanc and colleagues offered a sequential program of CBT approaches to treat severe and refractory mood disorders.

MPH is the more often prescribed stimulant for Attention Deficit Hyperactivity Disorder (ADHD), but it has been estimated that 30% of patients do not adequately respond or cannot tolerate it. Therefore, some other therapies are needed, such as cognitive behavioral therapy. Cognitive behavioral therapy is an intervention proposed over several sessions and aimed at modifying behavior by teaching different techniques that participants can re-use to control their symptoms. In our Institute, we used a program centered on attentional and metacognitive functions. It consists of a series of workshops performed in group at the rate of one workshop of 90minutes per week for 12 weeks. Positive effects on the behavior of adolescents with ADHD have been reported by parents and educators, but the effects of the program on specific cognitive processes have never been precisely investigated.In the present study, we evaluated the impact of the program on impulsive control in adolescents with ADHD who are known to present impaired impulsive control. Impulsive control is required each time there is a conflict between an inappropriate prepotent action and a goal-directed action. At an experimental level, impulsive control can be studied with conflict tasks, such as the Simon reaction time task. Interpreted within the theoretical framework of the so-called « Dual-process activation suppression » (DPAS) model, this task is a powerful conceptual and experimental tool to separately investigate the activation and inhibition of impulsive actions, which is almost never done in studies about impulsive control. Twenty adolescents followed the program and were tested before and at the end of the program by using dynamic analyses of performance associated with DPAS model.The results have shown an improvement of the impulsive control after three months of cognitive behavioral therapy, and this improvement was due to both a decrease of the propensity to trigger impulsive actions and an improvement of inhibitory processes efficiency.This program could be a relevant alternative to the stimulant medication, more particularly when parents are reluctant with medication or when the adolescent suffers from important side effects.

What prescription for psychostimulants in children? The Attention Deficit and Hyperactivity Disorder (ADHD) is a frequent disorder in children and adolescents. The diagnosis is clinical with the input of several informants (child, family, teachers…). ADHD is a risk factor for academic difficulties, school dropout, social isolation, injury, oppositional behaviour. In school-age children and adolescents having moderate to high or persistent impairment despite psycho-educational support and environmental modification, the first-line treatment is methylphenidate. Group or individual cognitive behavioural therapy for parents and/or children and adolescents is recommended for co-occurring disorders and persistent impairment. In France, the initiation of methylphenidate requires an annual hospital prescription by a paediatrician or psychiatrist, and a regular medical supervision (weight, heart rate, blood pressure…). At least once a year, the indication of methyphenidate needs to be re-evaluated and confirmed at the hospital. In case of lack of efficiency and/or poor tolerance, therapeutic alternatives including non-psychostimulants should be considered.Quelle prescription des psychostimulants chez l’enfant ? Le trouble du déficit de l’attention avec ou sans hyperactivité (TDAH) est l’un des troubles mentaux les plus fréquemment observés chez les enfants et adolescents. Le diagnostic est clinique, fondé sur l’entretien et l’observation, en tenant compte de plusieurs sources (patient, famille, école...). Les conséquences de ce trouble peuvent être l’échec scolaire, l’isolement social, des dommages corporels, des comportements oppositionnels/agressifs... Lorsque le retentissement est modéré à sévère, ou persistant malgré les aménagements environnementaux, le traitement pharmacologique à envisager en première intention est le méthylphénidate. Ce traitement impose une prescription annuelle hospitalière et une surveillance clinique régulière (poids, fréquence cardiaque, pression artérielle...). En cas de mauvaise tolérance et/ou d’efficacité insuffisante, d’autres traitements médicamenteux peuvent être prescrits. Il est nécessaire de réévaluer au moins une fois par an l’indication du traitement médicamenteux.

The experience of living with asthma varies between patients. In some cases, the psychological experience can take a central place and determine the course of asthma. Asthmatic disease can be complicated by adaption disorders that hamper the treatment, or genuine anxiety and depressive disorders that require the intervention of mental health specialists. Even more, the psychological experience can influence the intensity and frequency of the physical symptoms themselves, for example when asthma is associated with a hyperventilation syndrome worsening the functional impact and complicating the treatment. In this article, we underline the significance of the psychological experience through several clinical vignettes of patients suffering from asthma. In particular, we discuss the role of denial, or conversely identification with the status of being a patient, and the importance of the emotional experience associated with the symptoms of asthma. We highlight the relevance of therapeutic education programs as well as cognitive-behavioral therapies and psycho-corporal techniques, such as relaxation, for the psychological care of asthmatic disease. Finally, we detail how to better recognize a hyperventilation syndrome associated with asthma, how it can be approached with the patient and the treatment options. Through these examples, we illustrate the relevance of a comprehensive approach that integrates the psychological experience into the care of asthmatic disease.

Talking about sexuality of the elderly remains a taboo in our society. However, care given in a Cognitive and Behavioural Unit to people with major neurocognitive disorders can led health professionals to being confronted with sexuality of patients. We discuss about elements that distinguish sexual behavioural disorders, including ability to consent to sexuality, as well as elements useful in care of innapropriate sexual behaviours.

International audience; The exposure in cognitive behavioral therapy (CBT) is a well-known intervention, widely investigated in scientific research. Several studies have shown the benefits of this intervention in the treatment of anxiety disorders, obsessive-compulsive disorders (OCD) and post-traumatic stress disorders (PTSD). The different exposure techniques are mainly based on the emotional processing of fear theory and use an emotional stimulation of fear, following by its habituation. However, new approaches have emerged and are based on the inhibitory learning theory. The virtual reality technology allows emotional involvement from patients and represents a complementary approach to the classical modalities of exposure therapy (e.g., mental or in vivo expositions). This modern approach presents specific features that need to be taken into account by the therapist. Firstly, the presence feeling, which is defined as the “be there” feeling. This feeling is dependent on immersive technical features and personality factors. Secondly, virtual reality sickness, similar to motion sickness, represents a limitation that might prejudice a virtual therapy. The main scientific investigations of Virtual Reality Exposure Therapy (VRET) for treating social phobia, specific phobia, PTSD, and panic disorders are encouraging and demonstrate a similar effectiveness between both in vivo and in virtuo exposures. The scarce investigations on generalized anxiety disorders and OCD also suggeste a similar effectiveness between these exposures. However, further scientific investigations are needed to support these preliminary findings. The attrition rates and deteriorating states are similar to classical CBT approaches. Nevertheless, scientific literature presents several limits: 1) much of the research on this topic has interest conflicts (e.g., developers are also authors of a large number of studies); 2) there is a high heterogeneity of materials and virtual environments used; 3) important measures are not always taken into account in scientific research (e.g., the presence feeling); and 4) a massive use of waiting lists as a control measure. Despite these limitations, the VRET have strong silver linings: 1) the easy access to exposure (less limited than standard exposure techniques) and a cost reduction; 2) highly guaranteed security; 3) the anonymization of exposures (i.e., the patients do not risk meeting someone they know during the exposure therapy); 4) the therapist has a greater control of exposures; 5) a standardization of the exposures; 6) a greater involvement in therapy for technophile patients. Virtual exposure also seems to be generally more accepted by patients.; L’exposition en thérapie cognitivo-comportementale est une intervention bien connue et étudiée. Différentes études ont montré les bénéfices de cette intervention, même isolée. La technologie de réalité virtuelle fournit une approche complémentaire aux modalités d’exposition classique (e.g., par imagination ou in vivo). Elle présente également différentes caractéristiques spécifiques dont le thérapeute doit être conscient (i.e., présence, immersion, cybermalaise). Les données générales, concernant la VRET dans le traitement des phobies sociales, des phobies spécifiques, des états de stress post-traumatiques et des troubles paniques, sont encourageantes et démontrent, jusqu’à présent, une efficacité comparable entre les modalités classiques et l’exposition in virtuo. Les rares données concernant les troubles anxieux généralisés et les troubles obsessionnels compulsifs suggèrent un potentiel thérapeutique comparable. Les taux d’attrition et de détérioration sont comparables aux modalités classiques. La littérature scientifique, à ce sujet, présente cependant plusieurs limites : un nombre important d’études présente des conflits d’intérêts (e.g., prévalence importante des développeurs parmi les auteurs) ; la mesure de certains paramètres clés n’est pas systématisée (e.g., sentiment de présence) ; un usage massif des listes d’attente dans les groupes contrôles. Cette technique présente également un avantage par : la réduction des coûts et l’accessibilité à l’exposition ; l’aspect sécurisé des expositions ; une anonymisation lors de l’exposition ; la possibilité de contrôle de l’exposition par le thérapeute ; une possible standardisation des expositions ; une possible plus-value chez certains profils de patients technophiles. Elle semblerait également mieux acceptée par les patients.

The aim was to synthesize current knowledge on overactive bladder (OAB) first-line treatments.A systematic literature review based on PubMed, Embase and Google Scholar was conducted in June 2020.Behavioral treatments are based on bladder training and timed voiding using a bladder diary. Lifestyle modifications should be suggested. They include reduction of fluid intake, consumption of caffeine, sodas, weight loss, avoidance of acidic fruit juices and of spicy and acidic salty diet, alkalization of urine by diet and possibly, vitamin D supplementation. Pelvic floor muscle training is mainly based on manual techniques, electrostimulation and/or biofeedback. It has been shown to be effective in treating OAB. In menopausal women, local hormone therapy improves all OAB symptoms. Oral drugs include anticholinergics and beta-3-agonists. Their efficacy is quite similar and superior to placebo. In case of failure of monotherapy, they may be combined.Apart from some lifestyle modifications, the efficacy of first-line treatments for OAB has been demonstrated by prospective controlled studies. They may be prescribed individually or in combination.

Body expression of mental disorders is common in adolescence. Only two literature reviews over the last five years have been identified about somatoform disorders in children., The present article provides a systematic review of articles in English, which concern "Somatic Symptom and Related Disorders" according to the DSM-5 (Diagnostic and Statistical Manual - 5th Edition) among adolescents.The article search was made on Medline, Psychinfo, Google Scholar, BiomedCentral, Central and tripdatabase (for grey literature) according to PRISMA criteria and with the items "somatoform disorders" or "somatic symptom disorders". An age filter was applied for "adolescents", and a selection was done from the last five years. All articles concerning adolescents (often associated with children) were initially included, except for articles concerning eating disorders, dysmorphic disorders or adult population. Comments, editorials, opinion or descriptive articles were also excluded. The authors then carried out an analysis of the main topics, themes and questions covered in the selected publications and presented a descriptive synthesis.A total of seventy-seven publications were included in the analysis, from three hundred and seventy-two publications. First, the terms used to refer to these "somatic symptom disorders" were varied, such as "somatization", "somatic complaints/symptoms", "functional disorder", "unexplained symptoms" and "somatoform disorders". Then, studies related just to adolescents were limited: most of studies included children and adolescents in their methodologies; and some of them questioned somatic symptoms from a developmental perspective. Case reports were the most represented articles among all medical specialties, with clinical descriptions about "functional neurological symptom disorder", "factitious disorder" and "somatic symptom disorder" with a medical disease, among children and adolescents. We sometimes observed a controversial borderline between psychological and somatic disorders. Various explanatory models appeared, especially the trauma path; familial and social environment was also pointed out, with a possible peer group effect; neurocognitive theories were finally described. The literature highlights the effectiveness of psychosocial therapies (especially the cognitive-behavioral therapy) and the importance of multidisciplinary management. Finally, a few studies with a qualitative methodology are represented.Only nine articles included "somatic symptom disorder" in their titles, despite a terminology valued by many authors (compared to "somatoform disorders" from the DSM-IV). The heterogeneity of terminologies, case reports and explanatory models witness a lack of connexions between medical specialties. This could explain in part the wandering of adolescents and their families in the health care system. It could also contribute to the delay before diagnosis, especially when neurological symptoms exist, and a late referral for psychiatric consultation. Further studies are needed to understand difficulties to use a clinical pathway among medical specialties, when the benefit of amultidisciplinary approach seems to be unanimous.

Non-drug therapies are an integral part of inpatient care in cognitive-behavioural units. As such, the rehabilitators working in the Corentin-Celton Hospital unit participate in the individualized care and rehabilitation project for the patient by conducting numerous individual and group workshops in co-therapy.

International audience; Bariatric surgery is the most effective treatment for obesity. Reported benefits include major weight loss, improvement in diseases associated with obesity, and better quality of life. Nevertheless, there is a long-term risk of deleterious physical and psychological effects: regained weight (30% of patients), depression, and body image dissatisfaction. The purpose of this review of the literature is to identify the contribution of cognitive-behavioral therapy (CBT) in the context of bariatric surgery. Eligible articles and published since 2003 were systematically searched in electronic databases (PsychoINFO, MEDLINE, PubMed and Academic Search). Among the 98 citations, eleven cross-sectional and longitudinal studies concerning bariatric surgery patients who participated in CBT programs fulfilled the inclusion criteria. The therapeutic efficacy of CBT was demonstrated in ten of the eleven studies. An improvement in eating behavior, comorbid psychological conditions, and body weight were reported in patients who participated in CBT group sessions before and/or after bariatric surgery. The beneficial effect of CBT in the context of bariatric surgery suggests interesting therapeutic perspectives. Further research is however needed to consolidate these early findings and to provide longitudinal follow-up data beyond 2 years post-surgery.

NON-PHARMACOLOGICAL TREATMENT FOR ANXIETY DISORDERS Anxiety disorders are the most common psychiatric condition presenting to primary care practitioners. Efficacious treatments for these disorders exist, including pharmacotherapy and psychotherapy. Cognitive behavioral therapy (CBT) is the psychotherapy of first choice in most patients with anxiety disorders. With access to psychological therapies being limited, CBT provided within primary care settings for anxiety is usually brief and focused to psychoeducation, exercise prescription and psychosocial support. Psychoeducation includes information about the psychophysiology of anxiety reactions and the rationale of available treatment possibilities. The general practitioner encourage patient to practice deep breathing, exposition, cognitive restructuring, problem solving, relaxation, mindfulness in a self-help format. Exercise (aerobic training, such as active walking or jogging) has been studied in anxiety and can systematically be recommended as adjunctive treatment.TRAITEMENT NON MÉDICAMENTEUX DES TROUBLES ANXIEUX Les troubles anxieux sont les troubles psychiatriques les plus fréquents vus en médecine générale. Des traitements efficaces existent, les médicaments et les psychothérapies. Les thérapies cognitives et comportementales (TCC) sont les traitements de première intention des troubles anxieux. Compte tenu d’un accès encore limité aux psychothérapies, la pratique des TCC par le médecin traitant est courte et centrée sur la psychoéducation, la prescription d’exercices et le soutien psychosocial. La psychoéducation associe une information sur la psychophysiologie de la réaction anxieuse et le principe des différentes thérapeutiques disponibles. Le médecin traitant encourage le patient à pratiquer le contrôle respiratoire, l’exposition, la restructuration cognitive, la résolution de problème, la relaxation et la méditation de pleine conscience. L’exercice physique (type aérobie, comme la marche active ou le jogging) a été étudié dans les troubles anxieux et peut être systématiquement recommandé comme approche complémentaire.

L’émergence de la sexualité chez certains enfants peut se faire de façon inquiétante. C’est le cas lorsqu’ils présentent des comportements sexuels problématiques (CSP) envers d’autres enfants et que ces comportements sont caractérisés par la présence d’indices de sévérité comme la coercition, la persistance malgré les interventions et lorsqu’ils causent de la détresse émotionnelle, etc. Parmi d’autres, la littérature scientifique soutient que deux facteurs représentent des défisimportants : 1) la présence de difficultés concomitantes; 2) la mobilisation dans l’intervention qui se manifeste par un taux d’attrition élevé. Toutefois, peu d’études ont porté sur les dimensions qui évoluent dans le cadre d’une intervention spécialisée, particulièrement sur les autres difficultés qui se manifestent souvent chez ces enfants de façon concomitante. Ainsi, considérant les différentes difficultés vécues par ces enfants, il apparait important de noter si elles diminuent en intensité, tout comme les CSP, à la suite de la psychothérapie. De surcroît, considérant le taux d’attrition élevé dans les programmes destinés aux jeunes en difficulté, il s’avère pertinent de comprendre quels éléments sont susceptibles de prédire la non-complétion. La présente étude vise trois principaux objectifs : 1) décrire l’échantillon étudié, de même que les difficultés vécues par les enfants se manifestant en parallèle à leurs CSP ; 2) évaluer si les CSP et les difficultés concomitantes diffèrent à la suite de la thérapie ; 3) identifier les facteurs associés à la non-complétion de la psychothérapie. Cette recherche permet donc d’avoir une vision plus globale des différences entre le début et la fin de la thérapie quant aux difficultés éprouvées par ces enfants provenant de milieux variés. Elle permet également d’avoir une compréhension plus approfondie des enfants, mais plus globalement des familles qui ne complètent pas la thérapie leur étant destinée. L’échantillon initial est composé de 67 dyades parents-enfants référées dans un service de psychothérapie spécialisée en CSP. La psychothérapie adoptée étant d’approche cognitive comportementale, elle impliquait la participation d’une figure parentale et visait la gestion des CSP et la communication parent-enfant. Ces dyades ont été évaluées selon un devis à deux temps de mesure, impliquant des entrevues individuelles avant et après la psychothérapie. Les enfants, de même que les parents ont rempli différents questionnaires standardisés, portant notamment sur le développement de l’enfant et sur son comportement. Les résultats de la recherche révèlent des effets bénéfiques de la psychothérapie. Les enfants qui complètent la psychothérapie vivent davantage en situation de placement et ne sont pas accompagnés d’un parent biologique lors des rencontres, en comparaison à ceux qui ne la complètent pas. Aucune variable retenue dans la présente étude ne permet toutefois de prédire la non-complétion de la thérapie. Ces résultats sont discutés en considérant les implications pour la recherche et les interventions., Sexual development can be worrisome in certain children, in particular when sexual behavior problems toward others are manifested. Such behaviors are characterized by the presence of severity indexes such as coercion, emotional distress, persistence despite interventions, etc. Among others, the scientific literature highlights two important challenges in children with SBP: 1) the presence of concomitant difficulties; 2) mobilization during the intervention as manifested by a high dropout rate. However, few studies have examined the outcomes of specialized intervention on difficulties manifested in conjunction to SBP. Considering the variety of concomitant difficulties experienced by these children, it seems important to assess the influence of psychotherapy on the intensity of these problems. Moreover, given the high rate of attrition in intervention behavior problems in children, it is important to understand the factors that might predict dropout. The aim of this study is : 1) to describe the sample, as well as difficulties that are manifested in conjunction to SBP; 2) assess changes in SBP as well as in other difficulties after psychotherapy (internalizing and externalizing behaviors problems, post-traumatic symptoms, dissociation, self-esteem, depression, anxiety and social problems); 3) to identify factors associated with the dropout of psychotherapy. This research provides a more holistic comprehension of the differences between the beginning and the end of therapy with respect to the difficulties experienced by children with SBP, which are coming from a variety of backgrounds. It also allows for a deeper understanding of those children, but more generally their families who do not complete the therapy. The initial sample is composed of 67 parent-child dyads referred to a specialized cognitive behavioral psychotherapy for children with SBP. The psychotherapy required the participation of a parental figure and aimed the management of SBP as well as parent-child communication. Data were obtained during individual interview prior and post psychotherapy. The children as well as the parents both completed different standardized questionnaires, regarding the child’s development and his behavior. The results of the research indicate beneficial effects of psychotherapy on SBP and on other indicators of distress. Furthermore, the study has shown that children who complete psychotherapy are more likely to live in foster homes and to be accompanied by their biological parents when attending appointments as compared to those who drop out. However, no variables used in this study predict dropout during psychotherapy. These results are discussed while considering the implications for research and practice.

How can we respond differently to the demographic challenge of the growing population of seniors with cognitive-behavioural problems? The gerontology pole of the University Hospital Centre of Nîmes has installed a simulation room through a call for projects that has made it possible to develop nursing skills to improve care.

A French governmental institute published, in February 2004, a report assessing the efficacy of psychotherapies in the light of the biomedical literature. It concluded that cognitive psychotherapies effectively cure common mental disorders, while the efficacy of psychodynamic therapies is not proven by scientific studies. Because many French mental health professionals are practicing with reference to psychoanalysis, this conclusion stirred up heated controversy. Since February 2004, numerous studies assessing psychodynamic therapies have been published in peer-reviewed biomedical journals. Moreover, these primary studies have been meta-analyzed in dozens of review articles. Here, we systematically review these meta-analysis articles.A systematic search for meta-analyses assessing psychodynamic therapies was performed using PubMed and identified 71 articles published from January 2004 to December 2019. Among them, 25 articles were judged to be relevant because they reported meta-analyses assessing the symptoms of common mental disorders in at least three distinct cohorts of adult patients. Although the primary studies included in these 25 meta-analysis articles often overlap, the selection criteria, calculation methods and results always differ between them. Therefore, we reviewed all of them without further selection. From all the meta-analyses reported in these 25 articles, we systematically present here the most compelling ones, i.e. those calculated from the largest number of primary studies. Results were quantified in terms of effect size (i.e. standardized mean difference). Effect sizes below 0.25 were considered as without clinical significance, whereas those superior to 0.8 were regarded as robust. Because short-term psychodynamic therapies had been assessed in 20 meta-analysis articles published until 2017, we did not search for more recent primary studies. However, because the most recent meta-analysis article about long-term psychodynamic therapies was published in 2013, we also searched, using PubMed, for primary studies assessing psychodynamic therapies lasting for at least one year and published from January 2013 to December 2019. Among the 57 publications retrieved by PubMed, three were identified as randomized controlled trials not included in meta-analyses and were extensively described here.Eight meta-analysis articles have assessed symptom improvement at treatment termination by comparing with baseline symptoms. According to all of them, psychodynamic therapies alleviate symptoms and their effect sizes are always robust. Three meta-analysis articles compared psychodynamic therapies with inactive treatments (e.g. placebo medication, waiting list) and reported clinically significant differences in favor of psychodynamic therapies. Ten meta-analysis articles compared, at treatment termination, psychodynamic therapies to active treatments, including medication and cognitive psychotherapies. Nine of them reported no difference. Only one article concluded that psychodynamic therapies are clinically inferior to cognitive psychotherapies (d=-0.28). Seven meta-analysis articles compared psychodynamic therapies to active treatment at follow-up (i.e. months or years after treatment termination). Five of them reported no significant difference, one reported a medium effect size in favor of psychodynamic therapies over various active treatments (d=0.38), while the other reported a clinically significant difference in favor of cognitive psychotherapies (d=-0.55). Because short-term treatments are often insufficient to prevent relapse, investigations about long-term treatments (i.e. more than one year) are needed, but such published studies are still scarce. Five meta-analysis articles and three primary studies published since 2013 compared long-term psychodynamic therapies to various active treatments of similar duration. According to them, psychodynamic therapies were at least as effective as other active treatments.A systematic review about psychodynamic therapies, published in 2015 in Lancet Psychiatry, included 64 randomized controlled trials of which 37 were published after 2003. Therefore, most quality studies assessing psychodynamic therapies have been published since 2003 and have been reviewed in recent meta-analysis articles. All together, this recent literature leads to the conclusion that psychodynamic therapies are as effective as active treatments, including cognitive psychotherapies, to help patients suffering from common mental disorders (unipolar depression, anxiety disorders, eating disorders and personality disorders). Beside this overall conclusion, it appears that randomized controlled trials are not well suited for answering why psychotherapies work in some patients but not in others, and how they work in general. Other approaches are needed, including case studies.