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Objective: to prepare and evaluate orally disintegrating films of liquorice inclusion complexes. Methods: the active components of Chinese liquorice were extracted by pressurised extraction technique, and the inclusion complexes were prepared by antisolvent method, while the buccal disintegration films of liquorice inclusion complexes were prepared by solvent casting method, and the prepared buccal disintegration films were evaluated. Results: the home-made liquorice inclusion complexes orally disintegrated films formed better films, had good hardness and toughness, the thickness was around 0.1 mm and could disintegrate within 40 s, and the dissolution was rapid, the cumulative release reached 80.1% within 10 min, reaching the immediate release effect. Conclusion: the prepared buccal disintegrating membranes of liquorice inclusion complexes, which are expected to provide new ideas for the development and study of other drugs in the future, deserve further investigation.

In recent years, perovskite solar cells have been developed rapidly because of its excellent crystalline properties, high optical absorption coefficient, high carrier mobility, long carrier life and direct band gap, and suitable to be used as light absorbing layer material of photovoltaic devices. However, the most prominent problem of perovskite materials is that a lot of organic cations will migrate and lose in the process of illumination or heating, which is considered to be the main reason for the performance degradation of perovskite films and devices. Therefore, the suppression of ion migration in perovskite is helpful to improve the stability of perovskite materials and devices and enhance their photoelectric properties. In order to effectively control the ion migration in perovskite films, this paper uses the cation-π supramolecular interaction, to prepare the perovskite films with better photoelectric performance and higher stability. The experimental results show that the photoelectric conversion efficiency of the perovskite solar cellsdevice doped with rubrene is increased from 18.60% to 20.86%, and the hysteresis of the cell is also significantly suppressed.

The daily traffic volume of the State Grid 95598 Customer Service Center exceeds 800,000. In order to manage and store these massive data, we must carefully handle it. The call from electric customers implement the business philosophy of “Quality service is the lifeline of electric power enterprise”, and carry out related data aggregation, processing, statistics, conversion and analysis based on data warehouse, and fully explore and analyze these with big data analysis technology. The potential value in the data guides the optimization of business processes and improves the service quality and efficiency of the business center.

Abstract ATP-citrate lyase (ACL), one of the lipogenic enzymes, catalyses the formation of acetyl-coenzyme A (CoA) involved in the synthesis of fatty acid and cholesterol. In pig, very little is known about the ACL gene. In this work, the mRNA differential display technique was used to analyse the differences in gene expression between Meishan and Large White pigs and the F1 hybrids of both direct and reciprocal crosses. Our results show that among the differentially expressed genes ACL is up-regulated in the backfat of the F1 hybrids. After cloning and analysing the fulllength cDNA and the 870 bp 5'-flanking sequence of the porcine ACL gene, a C/T mutation at position -97 bp upstream of the transcription site was detected. Luciferase activity detection showed that this mutation changed the transcriptional activity. In F1 hybrids, the heterozygous genotype CT was more frequent than the homozygous genotypes CC and TT. Real-time PCR analysis showed that in Meishan pigs, ACL mRNA expression was more abundant in individuals with genotype CT than in those with genotype CC or TT or in Large White pigs. These results indicate that the C/T mutation affects ACL mRNA expression, probably via the activator protein 2.