Production operation is an important link in the teaching of drug production training course. It is of great significance to improve students’ understanding of basic knowledge and mastery of production norms.This paper probes into the reform and exploration of the teaching practice model of drug production by combining virtual simulation experiment teaching with practical operation.The implementation results show that by using virtual reality game elements and modes, the teaching mode combining serious game form with practical operation can stimulate students’ enthusiasm in learning, improve the interest of learning, facilitate the cultivation of students’ innovative ability and practical ability, and improve the teaching effect.Because this teaching method deeply integrates education, ideological and political education, cultivating students’ knowledge, ability and accomplishment, it helps to shape students’ correct values and outlook on life, enhance students’ dedication and sense of responsibility to participate in socialist construction and reform, and train students to coordinate interpersonal relations, learn to cooperate with groups, and improve their adaptability to employment in the future.