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Cryoablation therapy (CAT) has been recently introduced as an alternative means to treat prostatic cancer. Claimed advantages includes effectiveness in treating also locally advanced cancers and the low morbidity expecially if compared to the traditiona treatments, i.e. prostatectomy and/or radiation therapy. We report results observed in 23 patients with prostatic cancer treated with CAT. The results indicate that cryosurgery has a locally significant effect in destroying prostatic cancer not only in low stage, but even in a certain number of cases with locally advanced disease.