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In recent years, with the increasing energy consumption and carbon emissions, people are paying more and more attention to related measures for energy conservation and emission reduction. As an important conveying component of the HVAC system, the pipe network system plays the function of distributing the fluid medium. However, a large part of the resistance loss is often generated during this transportation process, and the local pressure loss caused by local resistance components (e.g., T-junction) accounts for a large part of the total pressure drop. In this work, the influence of different guide vane positions on the resistance of the T-junction is analyzed. The internal flow field distribution and resistance characteristics of the T-junction are explored by numerical calculation method. The total energy dissipation and resistance reduction rate of the traditional T-junction and the novel T-junction with a guide vane are compared under different flow ratios. The resistance reduction rate of the optimized T-junction with a guide vane is 21.5%. The insertion of guide vanes can reduce the flow resistance and total energy loss of T-junction.