Building a high-quality economic development evaluation system in ethnic areas can well solve the problems of unbalanced and inadequate high-quality economic development in regions; Method: By analyzing the government data of six adjacent cities in Yunnan, Sichuan, and Guizhou provinces, five primary indicators and 27 secondary indicators covering economic vitality, innovation efficiency, green development, people’s living and social harmony were constructed. By combining obstacle degree, coupling degree, and coupling coordination degree models, the high-quality development situation was empirically measured; As a result, Chuan D is weaker than the other five cities and states in four aspects: economic vitality, innovation efficiency, green development, and people’s livelihood, ranking first; The conclusion is to use it to evaluate and analyze the results of high-quality economic development in the six adjacent cities of Yunnan, Sichuan, and Guizhou provinces, and to revise the basic indicators of the system in order to better guide and guide the practice of high-quality economic development in ethnic areas.