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Your search keyword '"Vicogne, Jérôme"' showing total 2 results
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2 results on '"Vicogne, Jérôme"'

1. La chimie en Région Hauts-de-France : Chimie, biologie et santé

Author

Lebrun, Stéphane, Amouyel, Philippe, Biot, Christophe, Bonnet, Véronique, Déprez, Benoît, Gilormini, Pierre André, Lion, Cedric, Melnyk, Oleg, Melnyk, Patricia, Vicogne, Jérôme, Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources - UMR CNRS 7378 (LG2A ), Université de Picardie Jules Verne (UPJV)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Médicaments et molécules pour agir sur les Systèmes Vivants - U 1177 (M2SV), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 (M3T), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), and Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille

Subjects
[CHIM]Chemical Sciences
Abstract

International audience

Published
2017

2. [Schistosoma mansoni receptor tyrosine kinases: towards new therapeutic targets].

Author

Vicogne J and Dissous C

Subjects
Animals, Drug Design, Helminth Proteins physiology, Humans, Insulin metabolism, Receptor Protein-Tyrosine Kinases chemistry, Receptor Protein-Tyrosine Kinases classification, Receptor Protein-Tyrosine Kinases isolation & purification, Receptor Protein-Tyrosine Kinases physiology, Schistosoma mansoni drug effects, Schistosomiasis mansoni drug therapy, Schistosomiasis mansoni parasitology, Vaccines, Enzyme Inhibitors pharmacology, Helminth Proteins drug effects, Receptor Protein-Tyrosine Kinases drug effects, Schistosoma mansoni enzymology, Schistosomicides pharmacology
Abstract

In spite of numerous efforts towards the control of its transmission, schistosomiasis still remains an important parasitic disease and represents a serious public health concern and a major economical problem in a lot of developing countries. The detection in different S. mansoni endemic areas of resistance to Praziquantel, the only drug currently used against the parasite, was sufficient to motivate actively further research for the discovery of novel drug treatments. Specific inhibitors for tyrosine kinase receptors (such as EGF receptor) are currently used with success as anti-tumor drugs. As cell proliferation and differentiation are essential events in the complex life cycle of the schistosome, we have attempted to consider parasite growth factor receptors as potential targets for a new generation of anti-parasitic agents. Three RTK have been identified in S. mansoni: an EGF receptor, an insulin receptor and a third receptor with an original structure probably belonging to a new class of RTK never identified. Structural and functional analyses of the parasite receptors demonstrated the conservation but also the divergences with their vertebrate counterparts, which are therefore excellent candidates for strategies of specific parasite RTK inhibition.

Published
2003

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